Can Complete Blood Count Parameters Predict Retinopathy of Prematurity?

Ünsal, Alparslan; Key, Özge; Güler, Duygu; Ömürlü, İmran Kurt; Anık, Ayşe; Demirci, Buket; Dündar, Sema Oruç

doi:10.4274/tjo.galenos.2019.45313

Cited by 20 publications

(25 citation statements)

References 18 publications

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“…ey concluded that thrombocytopenia was associated with type-1 ROP, primarily zone-I ROP [7]. ere was no significant difference in terms of PLT counts between the groups in other studies [11,12,23,24]. Similarly, although PLT counts were lower in the type-1 ROP group, the difference was not significant in our study (p � 0.094).…”

Section: Discussioncontrasting

confidence: 62%

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The Role of Thrombocyte Parameters in Retinopathy of Prematurity Development

Özkaya

2022

International Journal of Clinical Practice

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Purpose. To investigate the role of thrombocyte parameters in retinopathy of prematurity (ROP) development. Materials and Methods. This retrospective study included 120 preterm infants in total. Group 1 was formed by infants who developed type-1 ROP and received treatment. Group 2 was formed by infants who developed ROP and were not treated for ROP. Infants who did not develop ROP and whose retinal vascularization was completed in their follow-up formed Group 3. Gestational age, birth weight, and genders of groups were recorded. Platelet (PLT) count, mean platelet volume (MPV), and platelet distribution width (PDW) values were obtained from complete blood count. Platelet mass index (PMI) was calculated by multiplying the PLT count by MPV value. Thrombocytopenia was defined as PLT count <150 × 1000/μL. All parameters were compared between the groups. Results. There were 40 preterm infants in each group. The mean PLT count was 272.43 ± 122.67 in Group 1, 333.32 ± 133.06 in Group 2, and 310.03 ± 119.41 in Group 3. The difference in PLT count between the groups was not significant p = 0.094 . Thrombocytopenia was observed in 25% of Group 1, 10% of Group 2, and 10% of Group 3 p = 0.095 . No statistically significant difference was found in terms of MPV, PDW, and PMI values between the groups ( p = 0.102 , p = 0.097 , and p = 0.298 , respectively). Conclusions. Although PLT count was lower and thrombocytopenia rate was higher in the type-1 ROP group, the differences were not found to be significant. Further prospective studies are required to evaluate the role of thrombocytes in ROP pathogenesis.

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Section: Discussioncontrasting

confidence: 62%

“…PDW was found as 15.8 in the non-ROP group and 15.9 in the ROP group. The difference in PDW was not statistically significant ( p =0.973) [ 24 ]. Similarly, no significant difference was found in terms of PDW between the groups in our study ( p =0.097).…”

Section: Discussionmentioning

confidence: 99%

The Role of Thrombocyte Parameters in Retinopathy of Prematurity Development

Özkaya

2022

International Journal of Clinical Practice

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“…found no difference in platelet counts between the ROP group ( n = 99) and the non-ROP ( n = 43) groups in the postnatal 4 th week. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity

Akdogan

Üstündağ

Çevik

et al. 2021

Indian Journal of Ophthalmology

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Purpose: To evaluate the prognostic potential of systemic inflammatory index in the course of retinopathy of prematurity (ROP). Methods: This is a retrospective case-control study. 303 infants with a gestational age of ≤35 weeks were screened with and without ROP at birth and 1 month after the birth of complete blood counts (CBC) were included in this study. Serum neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte (PLR), and systemic immune-inflammation index (SII) was calculated at birth and one month after. LMR was calculated by dividing the absolute lymphocyte count by the absolute monocyte count. NLR and PLR were determined by dividing the absolute neutrophil count or the absolute platelet count by the absolute lymphocyte count, respectively. The SII was calculated by the formula = neutrophilxplatelet/lymphocyte. All statistical analyses were performed using SPSS 22 (SPSS for Windows, version 22.0; SPSS, Inc. Chicago, IL, USA). Results: A total of 303 infants were included 145 with ROP and 158 without ROP. The NLR, LMR, PLR and SII values were 0.56 ± 1.17/0.51 ± 1.04 ( P = 0.997), 13.7 ± 18/9.49 ± 13.1 ( P = 0.014), 31.69 ± 68/24.1 ± 37.7 ( P = 0.268), 131.42 ± 326/124.66 ± 267 ( P = 0.935) in with ROP and without ROP infant at birth respectively. The NLR, LMR, PLR, and SII values were 0.68 ± 1.27/0.34 ± 0.99 ( P = 0.001), 2.58 ± 6.01/2.46 ± 14.5 ( P = 0.706), 47.5 ± 78.33/33.55 ± 42.4 ( P = 0.035), and 253 ± 681/114 ± 345 ( P = 0.001), respectively in with ROP and without ROP infant at 1 month after birth. Conclusion: The NLR, PLR, and SII seem an independent predictor of the development of ROP.

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“…The present study is limited by the nature of its retrospective design. Future directions for research may include the use of other haematological indices to allow earlier detection and treatment of this sight-threatening disease [ 31 ]. Besides this, the incorporation of haemoglobin levels into software algorithms, such as WINROP, which automatically alerts the clinician in cases of increased ROP risk, may also be beneficial [ 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

Pheng

Lim

Tai

et al. 2021

IJERPH

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Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder attributed to an ischaemic stimulus in preterm infants. Haemoglobin, the main component for oxygen transportation, may be implicated in ROP development. This retrospective study compared the mean weekly haemoglobin levels between infants with and without ROP over the first six weeks of life. Premature infants of less than 32 weeks gestational age and less than 1.5 kg birth weight were grouped into age and birth weight-matched ROP cases and controls. Weekly mean haemoglobin levels were documented. An independent t-test was used to analyze the difference in mean haemoglobin levels between infants with ROP and infants without ROP. Adjustment for confounders was performed using one-way analysis of covariance. There was a statistically significant difference in adjusted mean haemoglobin levels between the ROP and non-ROP group during the first week of life (p = 0.038). No significant intergroup differences were observed at the other weeks. Haemoglobin monitoring during the first week of postnatal life may be useful to guide ROP screening in premature infants.

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Can Complete Blood Count Parameters Predict Retinopathy of Prematurity?

Cited by 20 publications

References 18 publications

The Role of Thrombocyte Parameters in Retinopathy of Prematurity Development

The Role of Thrombocyte Parameters in Retinopathy of Prematurity Development

Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

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