2022
DOI: 10.3390/microorganisms10061167
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Can Corrole Dimers Be Good Photosensitizers to Kill Bacteria?

Abstract: Corroles possess key photophysical and photochemical properties to be exploited as therapeutic agents in antimicrobial photodynamic therapy (aPDT). Herein, we present for the first time the antimicrobial efficiency of three corrole dimers and of the corresponding precursor against the Gram(+) bacterium Staphylococcus aureus. Additionally, to explore future clinical applications, the cytotoxicity of the most promising derivatives towards Vero cells was evaluated. The aPDT assays performed under white light irra… Show more

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Cited by 8 publications
(1 citation statement)
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“…These contracted macrocycles, with three hydrogens in the inner core, present remarkable and unique properties, such as the ability to stabilize metal ions in high oxidation states, higher acidity, as well as higher emissions and quantum yields when compared to their porphyrinic counterparts [ 3 , 4 , 5 , 6 ]. These features are responsible for corroles’ unusual reactivity and, sometimes, unpredictable behavior, making the corrole macrocycles of great interest in various research areas, namely in the development of tumor-targeting and imaging drugs, antitumoral and antimicrobial photodynamic therapy [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ], sensing [ 25 , 26 , 27 , 28 , 29 , 30 ], design of light-harvesting systems [ 31 , 32 , 33 ], and catalysis [ 4 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”
Section: Introductionmentioning
confidence: 99%
“…These contracted macrocycles, with three hydrogens in the inner core, present remarkable and unique properties, such as the ability to stabilize metal ions in high oxidation states, higher acidity, as well as higher emissions and quantum yields when compared to their porphyrinic counterparts [ 3 , 4 , 5 , 6 ]. These features are responsible for corroles’ unusual reactivity and, sometimes, unpredictable behavior, making the corrole macrocycles of great interest in various research areas, namely in the development of tumor-targeting and imaging drugs, antitumoral and antimicrobial photodynamic therapy [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ], sensing [ 25 , 26 , 27 , 28 , 29 , 30 ], design of light-harvesting systems [ 31 , 32 , 33 ], and catalysis [ 4 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”
Section: Introductionmentioning
confidence: 99%