Can curcumin modulate allergic rhinitis in rats?

Acar, Mustafa; Muluk, Nuray Bayar; Yiğitaslan, Semra; Cengiz, Betül; Shojaolsadati, Paria; Karimkhani, Hadi; Ada, Servet; Berköz, Mehmet; Cingi, Cemal

doi:10.1017/s0022215116008999

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…In addition, curcumin reduced the infiltration of inflammatory cells, the proliferation of vessels in the lamina propria, and decreased cup cell metaplasia in the epithelium. As a result, curcumin can be considered as an effective treatment for allergic rhinitis in rats 146 …”

Section: Resultsmentioning

confidence: 99%

“…As a result, curcumin can be considered as an effective treatment for allergic rhinitis in rats. 146 Administration of curcumin (100 mg/kg) and bisdemethoxycurcumin (BDMC) (50, 100, and 200 mg/ kg) in OVA-sensitive allergic rhinitis mice showed an inhibitory effect on the increased IgE and histamine levels and suppressed the occurrence of nasal rubbing. In addition, BDMC stimulated the release of β-hexosaminidase and granules and suppressed membrane ruffling in monoclonal anti-2,4,6-dinitrophenyl IgE/human serum albumin (DNP-IgE/HSA).…”

Section: Experimental Evidencementioning

confidence: 99%

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Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review

et al. 2021

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Curcuma longa and its constituents, mainly curcumin, showed various of pharmacological effects in previous studies. This review article provides updated and comprehensive experimental and clinical evidence regarding the effects of C. longa and curcumin on respiratory, allergic, and immunologic disorders. Using appropriate keywords, databases including PubMed, Science Direct, and Scopus were searched until the end of October 2021. C. longa extracts and its constituent, curcumin, showed the relaxant effect on tracheal smooth muscle, which indicates their bronchodilatory effect in obstructive pulmonary diseases. The preventive effects of extracts of C. longa and curcumin were shown in experimental animal models of different respiratory diseases through antioxidant, immunomodulatory, and anti‐inflammatory mechanisms. C. longa and curcumin also showed preventive effects on some lung disorders in the clinical studies. It was shown that the effects of C. longa on pulmonary diseases were mainly due to its constituent, curcumin. Pharmacological effects of C. longa extracts and curcumin on respiratory, allergic, and immunologic disorders indicate the possible therapeutic effect of the plant and curcumin on these diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Experimental Evidencementioning

confidence: 99%

Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review

et al. 2021

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“…In another rabbit model of AR, AR was induced by IP administration of OVA on days 0, 2, 4 and 6, followed by its intranasal application for seven days (13) . In the literature, AR models have been described in rats induced by a total of 7 IP injections of OVA once a day on days 1, 3, 5, 7, 9, 11 and 13, followed by its once daily intranasal applications for 14 days (6,(14)(15)(16) .…”

Section: Discussionmentioning

confidence: 99%

“…Animal models of AR are extremely important for research studies on AR. To date, guinea pigs, mice, rats and rabbits have been used in animal models of AR (4)(5)(6)(7)(8) . Firstly, guinea pigs were used, and BALB/c type mice have been used mostly in recent years (4) .…”

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confidence: 99%

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A New Experimental Allergic Rhinitis Model in Mice

Köse¹,

Kiş²,

Diniz³

et al. 2021

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Objective: Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa mediated by IgE after exposure to an allergen. The most well known related comorbidity of AR is asthma. This study was planned due to the need for an animal model for studies on AR-asthma coexistence. In this study, the frequency of AR accompanying in the asthma model created in mice,and the usability of the related model in AR studies will be investigated. Methods: In our study, 6-8 week-old, 18-20 g BALB/c mice were used. Chicken egg ovalbumin (OVA Grade V, Sigma) was administered through intraperitoneal (IP) route at doses of 10 μg on days 0 and 14. Mice were exposed to aerosolized 2.5% ovalbumin solution in sterile saline for 30 minutes 3 days a week for 8 weeks, starting 7 days after the last IP administration (21st day). After exposure to OVA, mice were observed for typical signs of AR including sneezing, runny nose, and nasal itching. The final diagnosis of AR was made by histopathological examination of the rhinotracheal tissues of mice. Results: In our study, all mice exposed to ovalbumin received histopathologic diagnosis of AR. Increased number of capillaries lymphocytes, polymorphonuclear leukocytes and eosinophilsper square millimetre of rhinotracheal tissues were calculated in the murine model of AR compared to the the control group. Conclusion: This study introduced a new AR model, not cited in the literature, and induced with the longest-term ovalbumin exposure in the literature. It was concluded that this model, known as the asthma model, can also be used to induce an AR model and can be used in studies investigating coexistence of allergic rhinitis and asthma.

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The Role of Substance P Receptor Antagonists in Allergic Rhinitis: Ovalbumin‐Induced Rat Model

et al. 2023

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ObjectiveSubstance P is a peptide from the tachykinin family, which is found in peripheral and central nervous systems, causing vasodilation and increased secretion in the nasal mucosa. In this study, we aimed to investigate whether the experimental model of allergic rhinitis will cause allergic changes in the larynx and to compare the effects of aprepitant, a substance P antagonist, on nasal symptoms in allergic rhinitis, and histopathological changes in the nasal and laryngeal mucosa with antihistamine and leukotriene receptor antagonists (LTRA).Study DesignAn experimental animal study.MethodThe study was carried out on 34 healthy 8–12 weeks old female Sprague Dawley rats in 5 groups. The rats in which an experimental allergic rhinitis model was created with ovalbumin were scored by observing their nasal symptoms, and nasal and laryngeal mucous membranes included in the study were evaluated histopathologically after medications.ResultsAs a result of the analysis of the data obtained from the study, antihistamine and LTRA significantly reduced the symptoms of nose scratching and sneezing, while aprepitant did not affect nasal symptoms. In the histopathological examination of the larynx, effects that would make a significant difference were found in the allergy group when compared to the control group. On the larynx, aprepitant reduced pseudostratification significantly compared to the allergy group.ConclusionAprepitant provides histopathological changes in the treatment of allergic rhinitis, but does not have sufficient effect on nasal symptoms. The effect of aprepitant on the larynx has not been clearly demonstrated.Level of EvidenceNA Laryngoscope, 2023

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Can curcumin modulate allergic rhinitis in rats?

Abstract: Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.

Cited by 12 publications

References 28 publications

Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review

Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review

A New Experimental Allergic Rhinitis Model in Mice

The Role of Substance P Receptor Antagonists in Allergic Rhinitis: Ovalbumin‐Induced Rat Model

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