Can Diet Prevent Urological Cancers? An Update on Carotenoids as Chemopreventive Agents

Konecki, Tomasz; Juszczak, Aleksandra; Cichocki, Marcin

doi:10.3390/nu14071367

Cited by 8 publications

(3 citation statements)

References 83 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The carotenoid class is well known due to the provitamin A activity of some of its members, primarily the (all-E)-β-carotene, which displays the structural requirements to be bioconverted into two molecules of this indispensable nutrient after consumption. Furthermore, beneficial health effects of the dietary intake of provitamin A and nonprovitamin A carotenoids have been reported and comprise particularly the decreased risk of developing age-related macular degeneration and other eye conditions [22,23], some types of cancer [24,25], and cardiovascular [26,27] and bone diseases [28]. Humans depend on their diet to obtain carotenoids and consequently be exposed to these healthpromoting activities, with the chemical structure of these compounds determining their physicochemical properties; their behaviour through digestion, absorption, metabolism, and distribution; and ultimately, their biological efficacy [29,30].…”

Section: Introductionmentioning

confidence: 99%

A Scoping Review on Carotenoid Profiling in Passiflora spp.: A Vast Avenue for Expanding the Knowledge on the Species

Leite,

Bobrowski Rodrigues,

Brison

et al. 2024

Molecules

View full text Add to dashboard Cite

The Passiflora genus is recognised for its ethnopharmacological, sensorial, and nutritional significance. Yet, the screening of its dietary and bioactive molecules has mainly targeted hydrophilic metabolites. Following the PRISMA-P protocol, this review assessed the current knowledge on carotenoid composition and analysis within Passiflora, examining 968 records from seven databases and including 17 studies focusing on carotenoid separation and identification in plant parts. Those publications originated in America and Asia. P. edulis was the most frequently examined species of a total of ten, while pulp was the most studied plant part (16 studies). Carotenoid analysis involved primarily high-performance liquid chromatography separation on C18 columns and detection using diode array detectors (64.71%). Most studies identified the provitamin A β-carotene and xanthophylls lutein and zeaxanthin, with their geometric configuration often neglected. Only one study described carotenoid esters. Besides the methodology’s insufficient description, the lack of use of more accurate techniques and practices led to a high risk of bias in the carotenoid assignment in 17.65% of the articles. This review highlights the opportunity to broaden carotenoid studies to other species and parts within the diverse Passiflora genus, especially to wild, locally available fruits, which may have a strategic role in enhancing food diversity and security amidst climatic changes. Additionally, it urges the use of more accurate and efficient analytical methods based on green chemistry to better identify Passiflora carotenoids.

show abstract

Section: Introductionmentioning

confidence: 99%

A Scoping Review on Carotenoid Profiling in Passiflora spp.: A Vast Avenue for Expanding the Knowledge on the Species

Leite,

Bobrowski Rodrigues,

Brison

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Diet has been explored as a preventive strategy for bladder cancer, with strong evidence only found for arsenic in drinking water [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Limited evidence suggests that a higher consumption of vegetables, fruits, and tea may decrease the risk of bladder cancer [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Diet Quality and Risk of Bladder Cancer in the Multiethnic Cohort Study

Kang,

Wilkens,

Wirth

et al. 2024

Nutrients

View full text Add to dashboard Cite

This study analyzed the overall quality of the diet using predefined indices, including the Healthy Eating Index-2015 (HEI-2015), the Alternative Healthy Eating Index-2010 (AHEI-2010), the alternate Mediterranean Diet (aMED) score, the Dietary Approaches to Stop Hypertension (DASH) score, and the Dietary Inflammatory Index (DII®), to explore their association with the risk of bladder cancer in the Multiethnic Cohort Study. Data were taken from 186,979 African American, Japanese American, Latino, Native Hawaiian, and non-Hispanic White participants aged 45–75 years, with 1152 incident cases of invasive bladder cancer during a mean follow-up period of 19.2 ± 6.6 years. Cox models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) with comprehensive adjustment for smoking. Comparing the highest vs. lowest diet quality score quintile, HRs (95% CIs) in men was 1.08 (0.86–1.36) for HEI-2015, 1.05 (0.84–1.30) for AHEI-2010, 1.01 (0.80–1.27) for aMED, 1.13 (0.90–1.41) for DASH, and 0.96 (0.76–1.21) for DII®, whereas the corresponding HRs for women were 0.75 (0.53–1.07), 0.64 (0.45–0.92), 0.60 (0.40–0.88), 0.66 (0.46–0.95), and 0.63 (0.43–0.90) with all p values for trend <0.05. The inverse association found in women did not vary by smoking status or race and ethnicity. Our findings suggest that adopting high-quality diets may reduce the risk of invasive bladder cancer among women in a multiethnic population.

show abstract

“…A recent study has shown that making significant lifestyle changes can have an impact on the advancement of low-grade and early-stage prostate cancer [ 4 ]. For example, using 5-alpha reductase inhibitors [ 5 ], consuming green tea catechins [ 6 ], phytoestrogen [ 7 ], and carotenoids [ 8 ] have been found to affect the progression of the disease. Additionally, the intake of certain minerals, particularly zinc, calcium, and selenium, along with high consumption of dietary isoflavones, is recognized as factors that can influence the risk of prostate cancer [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium in Prostate Cancer: Prevention, Progression, and Treatment

Jiang,

Chen,

Tang

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Selenium, a trace mineral with various biological functions, has become a focal point in prostate cancer research. This review aims to present a comprehensive overview of selenium’s involvement in prostate cancer, covering its impact on prevention, development, treatment, and underlying mechanisms. Observational studies have revealed a link between selenium levels and selenoproteins with prostate cancer progression. However, randomized controlled studies have shown that selenium supplementation does not prevent prostate cancer (HR: 0.95; 95% CI 0.80–1.13). This discrepancy might be attributed to selenoprotein single nucleotide polymorphisms. In the context of combinatorial therapy, selenium has demonstrated promising synergistic potential in the treatment of prostate cancer. Emerging evidence highlights the significant role of selenium and selenoproteins in prostate cancer, encompassing AR signaling, antioxidative properties, cell death, cell cycle regulation, angiogenesis, epigenetic regulation, immunoregulation, epithelial–mesenchymal transformation, and redox signal. In conclusion, selenium’s diverse properties make it a promising trace mineral in prostate cancer prevention, development, and treatment and as a platform for exploring novel agents.

show abstract

Can Diet Prevent Urological Cancers? An Update on Carotenoids as Chemopreventive Agents

Cited by 8 publications

References 83 publications

A Scoping Review on Carotenoid Profiling in Passiflora spp.: A Vast Avenue for Expanding the Knowledge on the Species

A Scoping Review on Carotenoid Profiling in Passiflora spp.: A Vast Avenue for Expanding the Knowledge on the Species

Diet Quality and Risk of Bladder Cancer in the Multiethnic Cohort Study

Selenium in Prostate Cancer: Prevention, Progression, and Treatment

Contact Info

Product

Resources

About