Can drug-bearing liposomes penetrate intact skin?

Maghraby, Gamal M. El; Williams, Adrian C.; Barry, Brian W.

doi:10.1211/jpp.58.4.0001

Cited by 205 publications

(113 citation statements)

References 88 publications

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“…They are vesicles formed by one or multiple lipid bilayers that enclose an aqueous environment. Liposome deformability depends inversely on the amount of cholesterol in their composition and they can be negatively or positively charged [117]. Niosomes are made of mixtures of nonionic surfactants, cholesterol and, sometimes, small amounts of phospholipids, and were developed to increase the stability of liposomes.…”

Section: Nanodelivery Systemsmentioning

confidence: 99%

Delivery of drugs applied topically to the skin

Leite-Silva¹,

Almeida²,

Fradin

et al. 2012

Expert Review of Dermatology

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Section: Nanodelivery Systemsmentioning

confidence: 99%

Delivery of drugs applied topically to the skin

Leite-Silva¹,

Almeida²,

Fradin

et al. 2012

Expert Review of Dermatology

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“…Moreover, the liposomes as a drug carrier can provide high potential for transdermal delivery and targeted delivery to skin appendages. Liposomes as lipid carriers for triamcinolone acetonide showed increased drug concentration in SC as well as in the dermis by fivefold compared with a standard ointment of the same drug [78]. In one more research by the same authors, the incorporation of these liposomes encapsulating triamcinolone acetonide in a gel dosage form resulted in nonsignificant differences in drug concentrations in SC and dermis when compared with a gel containing liposome components as well as the free drug at the same concentrations [79].…”

Section: Liposomes For Transdermal Delivery Of Drugsmentioning

confidence: 95%

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim¹,

Nair²,

Al‐Dhubiab³

et al. 2017

Liposomes

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Polymeric networks that retain and absorb substantial amount of water or biological fluids and resemble as a biological tissue are defined as hydrogels. On the other hand, liposomes, transfersomes and niosomes are lipid carriers, which represent one of the major research and development focus areas of the pharmaceutical industry. They have great potential as lipid vehicles that are able to enhance permeation of drugs across the intact skin and can act as local depot for the drug to sustain and control its delivery. Lipid carrier and hydrogel combinations offer transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Also, lipid carriers can target drugs to skin appendages and improve transdermal delivery. Lipid carrier proform systems in the form of gelly liquid crystals can also be used transdermally for better drug absorption enhancement. This review highlights the potential of hydrogels and emulgels with or without lipid nanocarriers for dermal and transdermal application.

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“…One of the first strategies for transdermal delivery were the liposomes. The nature of liposomes makes them one of the best alternatives for drug delivery because they are non-toxic and remain inside the bloodstream for a long time [130][131][132][133]. Nevertheless, some factors affect the degree of transdermal drug penetration such as the lamellarity, the lipid composition, the charge on the liposomal surface, the mode of application and the total lipid concentrations [89,134].…”

Section: -Phase Inversion Temperaturementioning

confidence: 99%

Nanocarrier Systems for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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is an open discussion, in one hand, the nanotechnologist continue making new and more sophisticated nanocarriers and in the other hand, toxicologist continue evaluating possible damaging effects.Whatever it happens, nanotechnology is the new era and nanomedicine cannot be taking off. New nanocarriers will be created and the entire scientist working in nanomedicine bet for it to be the cure of diseases that in this moment are difficult to deal with [3] The application of preparations to the skin for medical purposes is as old as the history of medicine itself, with references to the use of ointments and salves found in the records of Babylonian and Egyptian medicine. The historical development of permeation research is well described by Hadgraft & Lane [4]. Over time, the skin has become an important route for drug delivery in which topical, regional or systemic effects are desired. Nevertheless, skin constitutes an excellent barrier and presents difficulties for the transdermal delivery of therapeutic agents, since few drugs possess the characteristics required to permeate across the stratum corneum in sufficient quantities to reach a therapeutic concentration in the blood. In order to enhance drug transdermal absorption different methodologies have been investigated developed and patented [5,6]. Improvement in physical permeationenhancement technologies has led to renewed interest in transdermal drug delivery. Some of these novel advanced transdermal permeation enhancement technologies include: iontophoresis, electroporation, ultrasound, microneedles to open up the skin and more recently the use of transdermal nanocarriers [3,[7][8][9][10].A number of excellent reviews that have been published contain detailed discussions concerning many aspects of transdermal nanocarriers [11][12][13][14][15][16][17]. The present chapter shows an updated overview of the use of submicron particles and other nanostructures in the pharmaceutical field, specifically in the area of topical and transdermal drugs. This focus is justified due to the magnitude of the experimental data available with the use of these nanocarriers. The development of submicron particles and other nanostructures in the pharmaceutical and cosmetic fields has been emerged in the last decades for designing best formulations for application through the skin [18][19][20][21]. The skinThe skin is the largest organ of the body [22][23][24], accounting for more than 10% of body mass, and the one that enables the body to interact more intimately with its environment. Essentially, the skin consists of four layers: The SC, that is the outer layer of the skin (nonviable epidermis), and forms the rate-controlling barrier for diffusion for almost all compounds. It is composed of dead flattened, keratin-rich cells, the corneocytes. These dense cells are surrounded by a complex mixture of intercellular lipids, namely, ceramides, free fatty acids, cholesterol, and cholesterol sulphate. Their most important feature is that they are structured as ordered bilayer arrays [25]...

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Can drug-bearing liposomes penetrate intact skin?

Cited by 205 publications

References 88 publications

Delivery of drugs applied topically to the skin

Delivery of drugs applied topically to the skin

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Nanocarrier Systems for Transdermal Drug Delivery

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