Can Familial Risk for ADHD Be Detected in the First Two Years of Life?

Miller, Meghan; Iosif, Ana Maria; Bell, Laura J.; Farquhar-Leicester, Alexander; Hatch, Burt; Hill, Alesha; Hill, Monique Moore; Solis, Erika; Young, Gregory S.; Ozonoff, Sally J

doi:10.1080/15374416.2019.1709196

Cited by 27 publications

(33 citation statements)

References 42 publications

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“…We found that activity level at 10 months (as rated by parents and observers) was predictive of preschool ADHD traits at 3 years, measured using the DSM ADHD subscale of the CBCL. These results are consistent with previous research that has associated infant activity level from 7 months of age with later ADHD [41], both in samples at elevated likelihood of ADHD [46,55], and population-based samples [47]. While in the present study we focused on preschool behaviours associated with the ADHD phenotype, there is some evidence in the previous literature that infant activity level shows specificity to ADHD symptoms into mid-childhood, rather than symptoms of co-occurring conditions such as anxiety or ASD [55].…”

Section: Longitudinal Associations Of Infant Attention and Activity Level With Preschool Adhd Traits At 3 Yearssupporting

confidence: 92%

Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits

et al. 2021

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Mapping infant neurocognitive differences that precede later ADHD-related behaviours is critical for designing early interventions. In this study, we investigated (1) group differences in a battery of measures assessing aspects of attention and activity level in infants with and without a family history of ADHD or related conditions (ASD), and (2) longitudinal associations between the infant measures and preschool ADHD traits at 3 years. Participants (N = 151) were infants with or without an elevated likelihood for ADHD (due to a family history of ADHD and/or ASD). A multi-method assessment protocol was used to assess infant attention and activity level at 10 months of age that included behavioural, cognitive, physiological and neural measures. Preschool ADHD traits were measured at 3 years of age using the Child Behaviour Checklist (CBCL) and the Child Behaviour Questionnaire (CBQ). Across a broad range of measures, we found no significant group differences in attention or activity level at 10 months between infants with and without a family history of ADHD or ASD. However, parent and observer ratings of infant activity level at 10 months were positively associated with later preschool ADHD traits at 3 years. Observable behavioural differences in activity level (but not attention) may be apparent from infancy in children who later develop elevated preschool ADHD traits.

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Section: Longitudinal Associations Of Infant Attention and Activity Level With Preschool Adhd Traits At 3 Yearssupporting

confidence: 92%

Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits

et al. 2021

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“…It is only if parents reported concerns that the screening process took place. This is a very similar categorisation protocol to that adopted by other labs using the prospective longitudinal study model in infants at elevated likelihood of ADHD (see Miller et al 2020).…”

Section: Participantsmentioning

confidence: 99%

Early Motor Differences in Infants at Elevated Likelihood of Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder

Ali

Charman

Johnson

et al. 2020

J Autism Dev Disord

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We investigated infant's manual motor behaviour; specifically behaviours crossing the body midline. Infants at elevated likelihood of Autism Spectrum Disorder (ASD) and/or Attention Deficit Hyperactivity Disorder (ADHD) produced fewer manual behaviours that cross the midline compared to infants with a typical likelihood of developing these disorders; however this effect was limited to 10-month-olds and not apparent at age 5 and 14 months. Although, midline crossing did not predict ASD traits, it was related to ADHD traits at 2 years of age. We rule out motor ability and hand dominance as possible explanations for this pattern of behaviour, positing that these results may be a consequence of multisensory integration abilities, and the neurobehavioural shift period, in the first year of life.

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“…Infant sibling studies, which systematically follow younger siblings to older children with ASD, indicate that certain temperamental characteristics can be spotted already during infancy in relation to later ASD (Johnson et al, 2015). Many studies have linked temperamental differences to ADHD-symptoms (De Pauw & Mervielde, 2010;Nigg, 2006) but only a handful recently published studies have used a familial risk design to understand ADHD symptomatology (Miller et al, 2016a(Miller et al, , 2016b(Miller et al, , 2020Sullivan et al, 2015). Interestingly, these studies suggest that temperamental differences can be detected already from the first year of life in infants with familial liability for ADHD (Miller et al, 2020).…”

mentioning

confidence: 99%

“…Many studies have linked temperamental differences to ADHD-symptoms (De Pauw & Mervielde, 2010;Nigg, 2006) but only a handful recently published studies have used a familial risk design to understand ADHD symptomatology (Miller et al, 2016a(Miller et al, , 2016b(Miller et al, , 2020Sullivan et al, 2015). Interestingly, these studies suggest that temperamental differences can be detected already from the first year of life in infants with familial liability for ADHD (Miller et al, 2020). ASD and ADHD aggregate in families, which means that later-born siblings to a child with ASD are not only at elevated likelihood for the same disorder, but also for ADHD (Ghirardi et al, 2018;Miller, Degnan, et al, 2018;Miller, Musser, et al, 2018).…”

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confidence: 99%

“…Research examining temperament in children with ASD and ADHD has generally relied on indirect measures, particularly parent questionnaires (for a review see Kostyrka-Allchorne et al, 2019). However, a few studies have used observational methods to explore early temperament in relation to ASD and ADHD (e.g., Hirschler-Guttenberg et al, 2015;Macari et al, 2018;Miller et al, 2020), although mostly focusing on negative behaviors, such as anger and frustration (Miller et al, 2020). While information from parents have been found to be useful, adding other measures could provide a more comprehensive evaluation of children's temperament (Karp et al, 2004).…”

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confidence: 99%

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How Does Temperament in Toddlers at Elevated Likelihood for Autism Relate to Symptoms of Autism and ADHD at Three Years of Age?

Konke

Forslund

Nilsson-Jobs

et al. 2021

J Autism Dev Disord

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The current study investigated longitudinal associations between parent-rated temperament, observed exuberance and accelerometer activity level at 18-months and symptoms of ASD and ADHD at 36-months in a sample of 54 children at elevated likelihood for ASD. For the specific parent-rated temperament scales, most observed significant associations appeared to be specific for either ASD or ADHD symptoms. Indeed, by controlling for overlapping symptoms a different pattern of associations emerged. These results illustrate how temperamental measures may signal risk for later ASD versus ADHD symptomatology in infants at elevated likelihood for ASD. In addition, they indicate the potential of adopting a broader view on neurodevelopmental disorders by investigating not only ASD traits, but also co-occurring disorders such as ADHD in samples of elevated likelihood for ASD.

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Can Familial Risk for ADHD Be Detected in the First Two Years of Life?

Cited by 27 publications

References 42 publications

Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits

Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits

Early Motor Differences in Infants at Elevated Likelihood of Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder

How Does Temperament in Toddlers at Elevated Likelihood for Autism Relate to Symptoms of Autism and ADHD at Three Years of Age?

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