Can family history be used as a tool for public health and preventive medicine?

Yoon, Paula W.; Scheuner, Maren T.; Peterson-Oehlke, Kris L; Gwinn, Marta; Faucett, Andrew; Khoury, Muin J.

doi:10.1097/00125817-200207000-00009

Cited by 313 publications

(267 citation statements)

References 37 publications

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“…4 With increasing access and decreasing price point for this type of risk assessment for common diseases such as cancer, healthcare providers and consumers are questioning how this type of profiling can be integrated into mainstream medicine, and how this type of genetic risk assessment compares with the standard of family health history-based risk assessment (FHRA). 5 Of all common disorders, scientific knowledge regarding genetic predisposition to cancer is amongst the most advanced. An average of 10% (range 1-30%) of all cancers can be attributed to high penetrance genetic predisposition.…”

Section: Introductionmentioning

confidence: 99%

Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers

2012

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Family history-based risk assessment (FHRA) is a genetic tool for identifying those at risk of disease. Genome-wide association studies have shown that single nucleotide polymorphisms (SNP) are statistically associated with low-to moderate-level risks of diseases. There has been limited study of complementarity for these two assessment methods. We sought to compare cancer risk categorizations from FHRA and from Navigenics Personal Genome Screening (PGS). We compared FHRA with PGS for breast (22 females), prostate (22 males), and colon cancer (44 males and females) assessed by kappa (j) statistic. We also assessed each participant's hereditary risk based on clinical criteria and/or gene-test results. Both FHRA and PGS placed 59%, 68% and 44% of participants into the same risk categories for breast, prostate, and colon cancer, respectively. Overall, however, there was little concordance in FHRA versus PGS for all three cancer risks (jo0.2). FHRA assigned 22 with hereditary risk compared with PGS, which identified one as high risk (Po0.0001). We assessed nine with hereditary colorectal cancer risk, five with germline mutations, but none were classified as PGS high risk (P¼0.0001). FHRA and PGS may be complementary tools for cancer risk assessment. However, evaluation of family history remains the standard to evaluate an individual's cancer risk until further research.

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Section: Introductionmentioning

confidence: 99%

Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers

2012

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“…First, family health history represented a conduit for understanding possible disease predisposition and effected behavior change (e.g., seeing the doctor). Echoing others, our data suggest that practitioners and researchers need to continue to find ways to increase the integration of family history into health prevention strategies (Yoon et al 2002).…”

Section: Discussionmentioning

confidence: 61%

Gene–environment interactions and health inequalities: views of underserved communities

et al. 2013

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This article examines the beliefs and experiences of individuals living in underserved ethnically diverse communities in Cleveland, Ohio, regarding the influence of genetic, social, and environmental factors on health and health inequalities. Using a community-engaged methodological approach, 13 focus groups were conducted with African American, Hispanic, and White individuals residing in the Cleveland area to explore attitudes and beliefs about genetics, genetic research, and health disparities and inequalities. Results of this study highlight the range of meanings that individuals attach to genetic variation, genomic research, and gene-environment interactions, and their implications for addressing health inequalities. The majority of participants in all focus groups reported that social and environmental factors were more important than genetics in contributing to health inequalities. Most participants were unfamiliar with genetic research. These data have implications for how genetic information and research might be applied in conjunction with addressing social determinants of health to improve prevention strategies in underserved communities and ultimately reduce health inequalities.

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“…The modern medical family history is a record of illnesses and other pertinent health issues among family members [2]. Conventional, albeit underused, applications of the family history include confirming medical diagnoses, identifying family members at risk for various conditions and calculating risk for developing a particular disease [3][4][5].…”

Section: The Family History the Origins Of The Family Historymentioning

confidence: 99%

“…Public health initiatives have recommended using the medical family history as an educational tool and developing a comprehensive record that can be kept by the patient requiring only regular updating [4,24,26]. This would accomplish both increased awareness of family history and compilation of important information that can be used in multiple medical contexts.…”

Section: Family History As Patient Empowermentmentioning

confidence: 99%

The Family History: Reemergence of an Established Tool

Hinton

2008

Critical Care Nursing Clinics of North America

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Can family history be used as a tool for public health and preventive medicine?

Cited by 313 publications

References 37 publications

Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers

Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers

Gene–environment interactions and health inequalities: views of underserved communities

The Family History: Reemergence of an Established Tool

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