Can Granisetron Injection Used as Primary Prophylaxis Improve the Control of Nausea and Vomiting with Low-Emetogenic Chemotherapy?

Keat, Chan Huan; Phua, Gillian Li Gek; Kassim, Mohd Shainol Abdul; Poh, Wong Kar; Sriraman, Malathi

doi:10.7314/apjcp.2013.14.1.469

Cited by 11 publications

(4 citation statements)

References 31 publications

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“…These data suggest that compliance with the guideline alone could not prevent emetogenicity. Consistent with this, a previous study also reported that sufficient measures could not prevent breakthrough CIV completely, even in low-risk patients [ 11 ]. In addition, some reports have discussed the difficulty of prevention using antiemetic guidelines for delayed CINV [ 12 , 13 ].…”

Section: Resultssupporting

confidence: 81%

Cohort study of consistency between the compliance with guidelines for chemotherapy-induced nausea and vomiting and patient outcome

Inoue

Shoji

Shindo

et al. 2015

BMC Pharmacol Toxicol

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BackgroundChemotherapy-induced nausea and vomiting is one of the most influential factors that affect patient quality of life; thus, preventing this adverse event could lead to better patient outcome. Standard preventive guidelines for antiemetic treatment have already been established based on the emetogenicity of chemotherapeutic agents. It is important that compliance with in-house guidelines and their effect on patient outcome is monitored.MethodsIn 3 years since the Akita university hospital antiemetic guidelines were outlined, we assessed the incidence of chemotherapy-induced nausea and vomiting using the antiemesis tool of the Multinational Association of Supportive Care in Cancer. Compliance of the guidelines was extracted from the hospital clinical record, and the chemotherapy-induced nausea and vomiting was examined by the patient reported outcome.ResultsSeventy-three patients answered the questionnaire. The overall compliance rate with the guidelines for early nausea and vomiting was 98.6% and with the delayed nausea and vomiting was 87.7%. The complete response rate for the early and delayed chemotherapy-induced nausea and vomiting was 77.8% and 73.8%, respectively. The overall relative risk of early nausea and vomiting was 0.22 (P < 0.05), whereas the relative risk for delayed nausea and vomiting was 2.09 (P < 0.05). Breakthrough vomiting was observed in 3 cases in the low-risk group only. These data suggest that delayed nausea and vomiting is difficult to prevent, particularly in the low-risk group. Further, it seems that the individual sensitivity for emetogenicity might differ among patients.ConclusionsIn addition to standard prevention guidelines based on emetogenicity, individual care based on patient reports should be considered for the complete prevention of chemotherapy-induced nausea and vomiting.Electronic supplementary materialThe online version of this article (doi:10.1186/s40360-015-0005-1) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 81%

Cohort study of consistency between the compliance with guidelines for chemotherapy-induced nausea and vomiting and patient outcome

Inoue

Shoji

Shindo

et al. 2015

BMC Pharmacol Toxicol

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“…In a single-facility study, adherence to guidelines in the low emetic potential group was only 11% because the remaining patients received a serotonin receptor antagonist in addition to corticosteroids. However, serotonin receptor antagonists, including the second-generation granisetron hydrochloride, have been proven to provide little benefit as primary prophylaxis in patients receiving chemotherapy with a low emetic risk . Unfortunately, few clinical trials of antiemetic prophylaxis or treatment of emesis associated with these drugs with low emetic risks have been published .…”

Section: Introductionmentioning

confidence: 99%

“…8 Adherence to the antiemetic guidelines has been repeatedly reported to be suboptimal in community practices. [12][13][14][15][16][17][18] Few studies have reported the patterns of prescribing antiemetic drugs for lower emetic risk groups. In a single-facility study, 14 adherence to guidelines in the low emetic potential group was only 11% because the remaining patients received a serotonin receptor antagonist in addition to corticosteroids.…”

mentioning

confidence: 99%

Prescription of Prophylactic Antiemetic Drugs for Patients Receiving Chemotherapy With Minimal and Low Emetic Risk

Okuyama¹,

Nakamura

Higashi³

2017

JAMA Oncol

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“…4 Mual muntah merupakan komplikasi yang sering terjadi akibat spinal anestesi, dengan angka kejadian 20-40%. 5 dalam penatalaksanaan asuhan keperawatan mual dan muntah dapat diatasi dengan terapi non farmakologis misalnya rebusan jahe dan rebusan daun papermint. Jahe merupakan tumbuhan rizoma dengan nama latin Zingiber officinale yang termasuk dalam family Zingiberaceae.…”

Section: Pendahuluanunclassified

Pemberian Rebusan Jahe dan Daun Pepermint Efektif dalam Pencegahan Nausea Pada Pasien Post Operasi dengan Anastesi Spinal di Ruang Bedah

Mustopa¹

2022

JIPKI

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Introduction: Spinal anesthesia can cause symptoms of pain, nausea, and vomiting that often occur in 80% of patients after anesthesia and surgery. Due to suture damage, regurgitation, aspiration, electrolyte balance, and dehydration if Post Operative Nausea Vomiting (PONV) is not treated and is a major concern in postoperative care. Nausea and vomiting are frequent complications of spinal anesthesia, with an incidence of 20-40%. Objectives: To compare the effect of boiled ginger and boiled peppermint in reducing the level of nausea and vomiting. Method: The type of research used in this study is a quasi-experiment with a Nonequivalent Control Group Design. Respondents in this study amounted to 15 people. Result: There was a decrease in the intensity of nausea and vomiting after being given ginger and/or peppermint decoction with the same effectiveness. The results of the Mann-Whitney U Test statistical test obtained a significance value of p-value = 0.472 < from 0.005. Conclusion:. There is a significant effect between ginger and peppermint decoction in reducing the level of nausea and vomiting in spinal anesthesia post-op patients in the operating room of the Bogor City Hospital with the same effectiveness value.

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Can Granisetron Injection Used as Primary Prophylaxis Improve the Control of Nausea and Vomiting with Low-Emetogenic Chemotherapy?

Cited by 11 publications

References 31 publications

Cohort study of consistency between the compliance with guidelines for chemotherapy-induced nausea and vomiting and patient outcome

Cohort study of consistency between the compliance with guidelines for chemotherapy-induced nausea and vomiting and patient outcome

Prescription of Prophylactic Antiemetic Drugs for Patients Receiving Chemotherapy With Minimal and Low Emetic Risk

Pemberian Rebusan Jahe dan Daun Pepermint Efektif dalam Pencegahan Nausea Pada Pasien Post Operasi dengan Anastesi Spinal di Ruang Bedah

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