Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?

Erb, Klaus J.

doi:10.1016/j.it.2008.11.005

Cited by 78 publications

(87 citation statements)

References 72 publications

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“…Since some parasitic worms seem to have a "calming" effect on the immune system, it seems likely that the trends are related. Indeed, clinical trials have shown that exposure to the eggs of the Trichuris suis whip worm can reduce the severity of symptoms in patients with Crohn's (e.g., Elliott et al, 2007;Erb, 2009;Summers, Elliott, Urban, Thompson, & Weinstock, 2005).…”

Section: Parasites and Inflammatory Diseasesmentioning

confidence: 99%

Gender and the hygiene hypothesis

Clough

2011

Social Science & Medicine

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a b s t r a c tThe hygiene hypothesis offers an explanation for the correlation, well-established in the industrialized nations of North and West, between increased hygiene and sanitation, and increased rates of asthma and allergies. Recent studies have added to the scope of the hypothesis, showing a link between decreased exposure to certain bacteria and parasitic worms, and increased rates of depression and intestinal autoimmune disorders, respectively. What remains less often discussed in the research on these links is that women have higher rates than men of asthma and allergies, as well as many auto-immune disorders, and also depression. The current paper introduces a feminist understanding of gender socialization to the epidemiological and immunological picture. That standards of cleanliness are generally higher for girls than boys, especially under the age of five when children are more likely to be under close adult supervision, is a robust phenomenon in industrialized nations, and some research points to a crosscultural pattern. I conclude that, insofar as the hygiene hypothesis successfully identifies standards of hygiene and sanitation as mediators of immune health, then attention to the relevant patterns of gender socialization is important. The review also makes clear that adding a feminist analysis of gender socialization to the hygiene hypothesis helps explain variation in morbidity rates not addressed by other sources and responds to a number of outstanding puzzles in current research. Alternative explanations for the sex differences in the relevant morbidity rates are also discussed (e.g., the effects of estrogens). Finally, new sources of evidence for the hygiene hypothesis are suggested in the form of cross-cultural and other natural experiments.

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Section: Parasites and Inflammatory Diseasesmentioning

confidence: 99%

Gender and the hygiene hypothesis

Clough

2011

Social Science & Medicine

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“…It impacts the quality of life and costs large medical expenditures to attenuate the hypersensitive symptoms. In total, 10-20% of the population worldwide suffers from allergies, and this number annually increases (1). Similarly to effector cells, mast cells are important in allergic inflammation through the production and secretion of allergic mediators, including histamine, chemokines, cytokines and growth factors (2).…”

Section: Introductionmentioning

confidence: 99%

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Liu

2017

Experimental and Therapeutic Medicine

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Abstract. Allergic inflammation is induced by allergens and leads to various allergic diseases, including rhinitis, asthma and conjunctivitis. Histamine is important in the pathogenesis of an immunoglobulin E-dependent allergic reaction and results in the secretion of cytokines associated with inflammation. Angelica dahurica (A. dahurica) is a medicinal plant widely used in China for the treatment of symptoms related to allergic inflammation. The present study investigated the chemical constituents from A. dahurica and evaluated their reductive effect on allergic inflammation. As a result, 15 compounds including 13 coumarins have been identified as isoimperatorin (1), imperatorin (2), oxypeucedanin (3), oxypeucedanin hydrate (4), bergapten (5), byakangelicin (6), phellopterin (7), byakangelicol (8), isopimpinellin (9), xanthotoxol (10), xanthotoxin (11), pimpinellin (12), scopoletin (13), β-sitosterol (14) and daucosterol (15). Compounds 1-13 were able to reduce the release of histamine, with compounds 4-6 exhibiting the most potent activity. Furthermore, compounds 1-12 were able to inhibit the secretion of tumor necrosis factor-α, interleukin (IL)-1β and IL-4, with compounds 5 and 7 exhibiting the strongest inhibitory effects. These compounds implemented the inhibitory effects on the expression of inflammatory cytokine genes through the inhibition of nuclear factor-κB activation. Virtual screening by a docking program indicated that compound 3 is a potent histamine H 1 receptor antagonist. Additionally, the calculated physicochemical properties of these compounds support most furanocoumarins to be delivered to binding sites and permeate the cell membrane. The present findings contribute to understanding how A. dahurica attenuates allergic inflammation.

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“…Öte yandan, helmint ürünlerinden bazıları, allerjik tepki seviyelerini düşürme potansiyeline sahiptir, ancak herhangi bir allerji modelinde henüz test edilmemiştir. Bu ürünlere örnek olarak, Dirofilaria immitis türevi antijen (DiAg), şistozomal lizofosfatidilserin (lizo-PS) ve Fasciola hepatica tarafından üretilen tioredoksin peroksidaz verilebilir [92] .…”

Section: Astım/allerjiunclassified