Can Hypothyroidism Cause Acute Central Serous Chorioretinopathy?

Ulaş, Fatih; Uyar, Enes; Tekçe, Hikmet; Çelebi, Serdal

doi:10.1080/08820538.2019.1684524

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…These data indicate that the pathogenesis of CSC may be correlated with systemic factors. Previously, researchers have reported that several hormones may play an important role in CSC pathogenesis [24,25]. In this study, the serum levels of NE, Cor and TT tended to increase in male CSC patients when compared with healthy volunteers of the same age.…”

Section: Discussionmentioning

confidence: 49%

Correlative study on retinal microvascular changes and sex hormones in male patients with central serous chorioretinopathy

2023

Journal of Men's Health

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Central serous chorioretinopathy (CSC) is a disease in which the outer retinal barrier is damaged with high incidence in young adult males. We aimed to analyze the correlations between retinal microvascular changes and sex hormone levels. The vascular density of the superficial retinal capillary plexus (SCP), deep retinal capillary plexus (DCP), foveal avascular zone (FAZ) area, choriocapillary blood flow area, and the subfoveal choroidal thickness (SCT) were investigated by optical coherence tomography angiography (OCTA). We also determined the levels of sex hormones (adrenaline (AD), norepinephrine (NE), dopamine (DA), corticosteroids (Cor), aldosterone (ALD), estradiol (E2) and total testosterone (TT)). The relationship between sex hormone levels and OCTA parameters was then determined. We detected significantly higher levels of NE, Cor and TT in serum from the observation group than in the control group (p < 0.05). Significant correlations were identified between SCT and choriocapillary blood flow area in the affected eyes, contralateral eyes and healthy eyes in the control group (p < 0.05). SCT levels of both eyes in the observation group were higher and the choriocapillary blood flow area was smaller than in the control group. The SCT in affected eyes from the observation group were higher than the contralateral eyes (p < 0.05). The choriocapillary blood flow area was significantly smaller than in the contralateral eyes (p < 0.05). Correlation analysis unveiled that NE, Cor and TT levels were positively correlated with SCT in CSC patients and negatively correlated with choriocapillary blood flow area (p < 0.05). The serum levels of sex hormone levels in male CSC patients were different from those in healthy men of the same age. Our findings suggest that the serum levels of NE, Cor and TT levels may influence the pathogenesis of CSC by affecting SCT thickness and choriocapillary blood flow.

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Section: Discussionmentioning

confidence: 49%

Correlative study on retinal microvascular changes and sex hormones in male patients with central serous chorioretinopathy

2023

Journal of Men's Health

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“…Ulas et al compared the blood values and OCT findings of patients with chorioretinitis and a control group and determined high TSH values and a thinner choroid and retinal cell layer at OCT in the group with chorioretinitis. They therefore concluded that that thinning occurs in the cell layer in individuals with hypothyroidism [18].…”

Section: Discussionmentioning

confidence: 99%

An examination of retinal findings with optical coherence tomography in hypothyroidism patients with vitamin D deficiency: A comparative study

Sayılan,

Kırağı,

Arslan

2023

J CLIN MED KAZ

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Aim: This study aimed to examine the retinal layer before and after treatment in patients with hypothyroidism with vitamin D deficiency, since the vitamin also protects the retinal cells against inflammatory damage. Material and methods: The free T3, free T4, and vitamin D levels of 104 patients with no ocular disease were first measured. Ophthalmological examinations of these patients, who were divided into three groups, were performed by specialist ophthalmologists, while retinal findings were examined using optical coherence tomography (OCT) and recorded. The first group was given vitamin D for three months, the second levothyroxine, and the third vitamin D + levothyroxine. After three months repeat OCT was performed, and the results were compared with the previous values. Results: The thickness of the left inner nuclear cell layer of the patients in the vitamin D group increased significantly compared to pre-treatment. Post-treatment right central macular thickness, right nerve fiber layer, right outer nuclear cell layer, right pigment epithelial layer, left central macular, and left inner nuclear cell layer thicknesses were all significantly higher compared to pre-treatment in the patients in the levothyroxine + vitamin D group, while right outer retinal layer and left retinal nerve fiber thicknesses decreased (p<0.05). Conclusion: A greater increase in cell layer thickness was observed in the group using vitamin D and levothyroxine together compared to those in which vitamin D and levothyroxine were employed alone. However, further studies on the effect of vitamin D on retinal cell development and protection against injury are now needed.

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“…Notably, Wysocka-Mincewicz et al ( 21 ) did not evaluate confounding factors, such as BP and lipid abnormalities, that could affect the capillary endothelial structure. Ulaş et al ( 22 ) reported a potential association between central serous chorioretinopathy and hypothyroidism, but the effect of the mean arterial pressure and blood glucose abnormalities on capillary endothelial dysfunction were not considered by them. Moreover, they did not consider lipid abnormalities and peroxidation caused by hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Optical Coherence Tomography Angiography Findings between Healthy Children and Children with Type 1 Diabetes Mellitus and Autoimmune Thyroiditis

Korkmaz

Devebacak

Değirmenci

et al. 2023

Jcrpe

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Objective: The aim of this study was to compare the development of early diabetic retinopathy (DR) findings, a microvascular complication, between patients with isolated type 1 diabetes mellitus (T1DM) (Group 1), concurrent T1DM and autoimmune thyroiditis (AT) (Group 2), and healthy controls (Group 3), who were matched for age, sex, number, and body mass index for comparison. Methods: This was a prospective observational study that included individuals aged 10-20 years, and patients in Groups 1 and 2 had been followed up for ≥5 years. None of them developed clinical DR during the follow-up period. Optical coherence tomography angiography (OCTA) was used to evaluate the foveal avascular zone (FAZ) and parafoveal vascular density (PVD) for the development of early DR. OCTA findings were compared between patients and healthy controls. Results: Thirty-five individuals were included in each of the groups. The mean FAZ and PVD differed significantly between the three groups (FAZ, p=0.016; PVD, p=0.006). The mean FAZ was higher in Groups 1 and 2 than in Group 3 (p=0.013 and p=0.119, respectively). The mean PVD was lower in Groups 1 and 2 than in Group 3 (p=0.007, respectively). No significant difference was found between Groups 1 and 2 in terms of the mean FAZ and PVD (p=0.832 and p=0.653, respectively). The mean glycated hemoglobin (HbA1c) level was significantly correlated with FAZ and PVD (FAZ: r=0.496, p<0.001; PVD: r=-0.36, p=0.001). Conclusion: In patients with T1DM who did not develop clinical DR, OCTA findings revealed an increase in FAZ, which was associated with higher HbA1c levels. The mean PVD was significantly lower in the group with coexisting AT and T1DM than in the control group. These results suggest that the coexistence of AT and T1DM can contribute to the development of microvascular complications. However, studies with larger patient series are required.

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Can Hypothyroidism Cause Acute Central Serous Chorioretinopathy?

Cited by 4 publications

References 29 publications

Correlative study on retinal microvascular changes and sex hormones in male patients with central serous chorioretinopathy

Correlative study on retinal microvascular changes and sex hormones in male patients with central serous chorioretinopathy

An examination of retinal findings with optical coherence tomography in hypothyroidism patients with vitamin D deficiency: A comparative study

Comparison of Optical Coherence Tomography Angiography Findings between Healthy Children and Children with Type 1 Diabetes Mellitus and Autoimmune Thyroiditis

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