Purpose:The aim of this study was to assess the effect of vitreous reflux and its amount on short-term intraocular pressure after intravitreal injection of ranibizumab.Methods:The study included 316 eyes of 276 patients. Intraocular pressures were measured before intravitreal injection (preIOP), immediately after intravitreal injection (postIOP0), and 30 min after intravitreal injection (postIOP30). The amount of vitreous reflux was evaluated by measuring conjunctival bleb diameter, and patients were grouped as; group 1: no vitreous reflux, group 2: less vitreous reflux, and group 3: more vitreous reflux. The data were analyzed using variance analysis, chi-square test, and regression analysis.Results:PostIOP0 values were highest in group 1, followed by group 2 and group 3 (all p values < 0.001). PostIOP30 values were similar in group 1 and group 2 (p = 0.261), but were lower in group 3 than other two groups (p < 0.001, p = 0.001, respectively). Vitreous reflux was identified as the only factor affecting postinjection intraocular pressure changes (p < 0.001), and a negative correlation was found between the total number of intravitreal injection and vitreous reflux (p = 0.032).Conclusion:The major factor affecting short-term postinjection intraocular pressure elevation was vitreous reflux, and intraocular pressure levels increased as the amount of vitreous reflux decreased. Vitreous reflux and its amount decreased as the total number of intravitreal injection increased.

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Purpose: To evaluate the efficiency of YouTube videos as a source of information for the treatment of amblyopia. Methods: The authors searched YouTube (Google) using the keywords “amblyopia treatment” and analyzed the first 200 most relevant videos. Videos were classified as useful or misleading by two independent ophthalmologists. Videos were scored on 5-point scales to evaluate global quality, reliability, and comprehensiveness. General characteristics, viewer interactions, and sources of videos were also recorded. Results: Eighty-seven of 200 videos were appropriate to be included in the current study. Fifty videos (57.5%) were classified as useful and 37 videos (42.5%) were classified as misleading. General characteristics and viewer interactions were not significantly different between useful and misleading videos ( P > .05). The mean Global Quality Score, reliability, and comprehensiveness scores were 3.64 ± 1.1, 3.02 ± 1.0, and 2.74 ± 1.2 in useful videos and 2.03 ± 0.9, 2.08 ± 0.8, and 1.62 ± 0.7 in misleading videos, respectively ( P < .05). The data suggested that most of the videos uploaded by university channels or non-profit professionals were useful (79.2%), whereas most of the videos uploaded by medical advertisements or for-profit companies were misleading (59.1%). Conclusions: The results of the current cross-sectional study demonstrated that the number of useful videos for the treatment of amblyopia was higher on YouTube. However, there was still a significant number of misleading videos (42.5%). Therefore, more videos on amblyopia treatment that have sufficient reliability, quality, and comprehensiveness should be uploaded to YouTube. [ J Pediatr Ophthalmol Strabismus . 2021;58(5):311–318.]