Can local administration of humic acid shorten recovery time of mandibular fractures? Experimental study

Durmuş, Kasım; Bora, Adem; Doğan, Mehtap; Özer, Hatice; Tuncer, Ersin; Altuntaş, Emine Elif

doi:10.2399/jmu.2017002008

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Durmuş et al 47 used 16 Wister Albino rats in the study in which they research local humic acid application to healing time in mandibula fractures. Rats were grouped as control group and local humic acid (0.3cc/zone) group.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Effect of Humic Acid on Bone Regeneration in Parietal Defects Formed in Rats Ratlarda Oluşturulan Pari̇etal Defektlerde Humi̇k Asi̇ti̇n Kemi̇k Rejenerasyonu Üzeri̇ne Etki̇si̇ni̇n Araştirilmasi

ŞENGÜL

Bostancı

2022

Cumhuriyet Dental Journal

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Objectives:The objective of our study was to investigate the effect of the local humic acid application in addition to autogenous bone grafting on the premature new bone amount.Materials and Methods: 12-week-old 24 Wistar rats were divided into 4 groups.Two parietal bone defects with 5-mm diameter were constituted in each animal. All defects in each group were treated with only autogenous bone graft (n=6), autogenous bone graft combined with 100 mg/kg (n=6) or 200 mg/kg humic acid (n=6). Defects in one group remained empty as control (n=6). The laboratory animals were sacrificed on the 28th day following the procedure. Morphological properties of all experimental defects were evaluated using micro-computed tomography (Micro-CT). Results:The highest value among trabecular thickness (Tb.Th) and the ratio of the bone volume to the tissue volume (BV/ TV) was encountered in the autogenous graft group applied with 100mg/kg humic acid. The highest value in the bone volume (BV) variance was detected in the group to which only the autogenous graft was applied. A statistically significant difference was found between the control group and the only autogenous graft-applied group and the autogenous graft group applied with local 100mg/kg humic acid upon comparing the groups in pairs for bone surface area (BS) variance. BS/BV value was found higher in the autogenous graft group applied with local 200mg/kg humic acid than the autogenous group applied with local 100mg/kg humic acid.Conclusions: Humic acid application in addition to autogenous bone grafting caused a decrease in the bone volume value. However, the positive effect of the humic acid application was observed in trabecular thickness and bone volume/tissue volume values, dosage increase negatively impacted the same. The dosage increase negatively affected the bone surface area value. No positive effect of the humic acid application to bone surface/bone volume value was observed. The statistical significance between the control group and the other groups is considered to be autogenous graft.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Effect of Humic Acid on Bone Regeneration in Parietal Defects Formed in Rats Ratlarda Oluşturulan Pari̇etal Defektlerde Humi̇k Asi̇ti̇n Kemi̇k Rejenerasyonu Üzeri̇ne Etki̇si̇ni̇n Araştirilmasi

ŞENGÜL

Bostancı

2022

Cumhuriyet Dental Journal

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“…Нами не визначено збільшення утворення кісткової тканини у імплантатах оброблених гумілідом як у кроленят модельної групи, що отримувала гумілід, так і у тварин у контрольному варіанті. Ця тенденція вказує на збільшення остеоінтеграції імплантатів за рахунок системного впливу гуміліду та про відсутність його локального впливу, що збігається з даними інших дослідників (Durmus et al, 2017).…”

Section: обговоренняunclassified

Features of mineral metabolism in rabbits during correction with biologically active feed additives against the background of implantation of PLA implants

Stepchenko¹,

Rybalka²

2020

TAVM

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The impact of humic acid additives on mineral metabolism of rabbits in the postnatal period of ontogenesis

Rybalka

Stepchenko

Shuleshko

et al. 2020

Regul. Mech. Biosyst.

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Humic acids are characterized by chelating properties due to which they are able to influence the mineral metabolism in animals. Rabbits have species-specific characteristics of mineral metabolism, which distinguishes them from most species of mammals. For the experiment, 16 rabbits of 45-day-old of Hyplus breed were divided into the experimental and control group of 8 rabbits in each. The animals were 15 days in the preparatory period. The rabbits of the experimental group received humic acid additive individually with water in the amount of 5 mg/kg, the rabbits of the control group received pure water in the same amount. The ability of humic acid additive to increase the content of calcium, ionized calcium, iron, to correct the content of copper and zinc, and also to increase the activity of alkaline phosphatase in the blood serum of rabbits of the experimental group has been proved. We observed the early effect of the humic acid additive on increasing the content of iron and calcium ionized and a later effect on the activity of alkaline phosphatase and an increase in the content of copper in the blood serum. The influence of humic acid additive on the distribution of calcium, phosphorus, manganese, copper and zinc in bone tissue is determined. According to a histological study, there was a significant increase in the number of layers of osteons and osteoblasts in the bone tissue of the femur, an increase in the number of osteons and osteoblasts in the bone tissue of the sternum and an increase in the number of columns of chondrocytes and an increase in the number of chondrocytes in the column in the cartilaginous tissue of the sternum. The results of a histological study of bone tissue, together with an increase in structural macroelements in it and redistribution of osteotropic trace elements in the blood and bone tissue suggest the possibility of using a humic acid additive to intensify the growth and mineralization of bone tissue, which can improve the state of bone tissue of rabbits in the postnatal period ontogenesis.

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Can local administration of humic acid shorten recovery time of mandibular fractures? Experimental study

Cited by 4 publications

References 17 publications

Investigation of the Effect of Humic Acid on Bone Regeneration in Parietal Defects Formed in Rats Ratlarda Oluşturulan Pari̇etal Defektlerde Humi̇k Asi̇ti̇n Kemi̇k Rejenerasyonu Üzeri̇ne Etki̇si̇ni̇n Araştirilmasi

Investigation of the Effect of Humic Acid on Bone Regeneration in Parietal Defects Formed in Rats Ratlarda Oluşturulan Pari̇etal Defektlerde Humi̇k Asi̇ti̇n Kemi̇k Rejenerasyonu Üzeri̇ne Etki̇si̇ni̇n Araştirilmasi

Features of mineral metabolism in rabbits during correction with biologically active feed additives against the background of implantation of PLA implants

The impact of humic acid additives on mineral metabolism of rabbits in the postnatal period of ontogenesis

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