Can magnetocardiography detect patients with non‐ST‐segment elevation myocardial infarction?

Lim, Hyun Chul; Chung, Namsik; Kim, Ki Woong; Ko, Young Guk; Kwon, Hyuk‐Chan; Lee, Yong-Ho; Kim, Jin Mok; Joung, Boyoung; Kim, Jin Bae; Hung, Kam; Cho, Jung Rae; Kim, In Soo; Park, Yong Ki

doi:10.1080/07853890701538040

Cited by 25 publications

(27 citation statements)

References 31 publications

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“…Previous studies have confirmed specific MCG findings in ischemic heart disease patients, and these investigations focused on the diagnostic value of MCG modality 91011. However, whether specific MCG findings could predict prognosis had not yet been elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies for diagnosis of ischemic heart disease using MCG suggests several MCG parameters, such as maximum current angle, distance of poles in current density vector (CDV), field map angle in MF maps and dipole or non-dipole patterns in T-peak, have significant correlation with myocardial ischemia 91014…”

Section: Methodsmentioning

confidence: 99%

“…Clinical research using MCG has been wide-ranging: it has been found to be more accurate than ECG for the evaluation of MI and ventricular repolarization abnormalities67 and is able to identify patients at risk for ventricular tachycardia 8. MCG has been proposed as a tool for risk-stratifying patients with AMI and ischemia 91011. Increased intra-QRS fragmentation in MCG predicts arrhythmic events, especially ventricular tachycardia and mortality in post-MI patients with left ventricular dysfunction 1213.…”

Section: Introductionmentioning

confidence: 99%

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Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction

et al. 2016

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PurposeMagnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI.Materials and MethodsIn 124 AMI patients (95 males, mean age 60±11 years), including 39 with ST-elevation myocardial infarction, a 64-channel MCG was performed within 2 days after AMI. During a mean follow-up period of 6.1 years, major adverse cardiac events (MACE) were evaluated.ResultsMACE occurred in 31 (25%) patients, including 20 revascularizations, 8 deaths, and 3 re-infarctions. Non-dipole patterns were observed at the end of the T wave in every patients. However, they were observed at T-peak in 77% (24/31) and 54% (50/93) of patients with and without MACE, respectively (p=0.03). Maximum current, field map angles, and distance dynamics were not different between groups. In the multivariate analysis, patients with non-dipole patterns at T-peak had increased age- and gender-adjusted hazard ratios for MACE (hazard ratio 2.89, 95% confidence interval 1.20–6.97, p=0.02) and lower cumulative MACE-free survival than those with dipole patterns (p=0.02).ConclusionNon-dipole patterns at T-peak were more frequently observed in patients with MACE and were related to poor long-term prognosis. Thus, repolarization heterogeneity measured by MCG may be a useful predictor for AMI prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction

et al. 2016

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“…Hence, MCG is much more sensitive to very weak cardiac signals [45]. In various clinical studies superior sensitivity of MCG for ischemic myocardium at rest, as well as under stress has already been shown [14,15,30,31,50]. Recently, MCG has been recognized for its outstanding ability to detect patients with coronary artery disease [11,13,36,37].…”

Section: Introductionmentioning

confidence: 99%

Validation of magnetocardiography versus fractional flow reserve for detection of coronary artery disease

Park

Shin

Ann

et al. 2015

Clinical Hemorheology and Microcirculation

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BACKGROUND: Although magnetocardiography (MCG) has been proposed as a non-invasive technique with high accuracy for functional diagnosis of myocardial injury, the validation of MCG against fractional flow reserve FFR in diagnosing coronary artery disease (CAD) has not yet been established. The goal of the study was to determine the diagnostic accuracy of MCG versus invasively determined FFR in patients with suspected or known CAD. METHODS: Forty seven patients with suspected CAD (35 men; mean age 69 years) who underwent coronary angiography and FFR measurement were enrolled. FFR ≤0.8 was considered to indicate significant myocardial ischemia. The change of ST-segment fluctuation score from rest to stress was calculated from the MCG. In addition, two blinded cardiologists assessed MCG images that were visualized by post-processing method, bull's-eye mapping. RESULTS: The best cut-off value of the percent change of ST-segment fluctuation score was −39.0% with sensitivity of 86.7% and specificity of 73.9%. Sensitivity, specificity, diagnostic accuracy, and the area under the receiver-operator characteristics curve of bull's-eye mapping for the detection of significant CAD were 90.5%, 92.3%, 91.5%, and 0.914 on a patient basis and 90.0%, 93.8%, 92.3%, and 0.919 by coronary territory, respectively. CONCLUSIONS: MCG accurately detects functionally significant CAD as defined by using FFR, provides an assessment of ischemic status in agreement with the change of ST-segment fluctuation score, and accurately localizes the ischemic territory in bull's eye mapping. Therefore, MCG may provide an incremental value for prediction of myocardial ischemia non-invasively and safely in clinical practice with fast examination time.

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“…The possible value of resting MCG investigations has been demonstrated by various working groups 121314151617. Specifically, bundle branch block (BBB) can obscure ECG diagnosis, and its presence is associated with a 50% higher false-positive admission rate in patients with suspected ACS 1819.…”

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confidence: 99%

Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction

Her

Park

2016

Yonsei Med J

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Can magnetocardiography detect patients with non‐ST‐segment elevation myocardial infarction?

Abstract: Our study showed that MCG has potential clinical application for detection of NSTEMI and should be further investigated.

Cited by 25 publications

References 31 publications

Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction

Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction

Validation of magnetocardiography versus fractional flow reserve for detection of coronary artery disease

Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction

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