2006
DOI: 10.1159/000091850
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Can Modification of Renal Replacement Therapy Improve the Outcome of Patients with Systemic Inflammatory Response Syndrome?

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Cited by 11 publications
(10 citation statements)
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“…The reasons could be that it reduces inflammation levels and relieves the inhibition of inflammatory mediators on cardiovascular function; directly clears endogenous substances such as NO and atrial natriuretic peptide that may expand blood vessels or inhibit myocardial systolic functions; adjusts the balance between positive material such as catecholamine and negative material; and improves oxygenation and restores metabolism of cardiovascular system. This study found that CBP treatment removed inflammatory factors such as TNF-α, IL-6, and IL-10 in serum and BALF, and thus nonselectively inhibited the inflammation medium, which was consistent with previous studies (11,12). At present, lung water content level and pulmonary edema are believed to be associated with the survival rate of patients with ARDS (13).…”
Section: Discussionsupporting
confidence: 93%
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“…The reasons could be that it reduces inflammation levels and relieves the inhibition of inflammatory mediators on cardiovascular function; directly clears endogenous substances such as NO and atrial natriuretic peptide that may expand blood vessels or inhibit myocardial systolic functions; adjusts the balance between positive material such as catecholamine and negative material; and improves oxygenation and restores metabolism of cardiovascular system. This study found that CBP treatment removed inflammatory factors such as TNF-α, IL-6, and IL-10 in serum and BALF, and thus nonselectively inhibited the inflammation medium, which was consistent with previous studies (11,12). At present, lung water content level and pulmonary edema are believed to be associated with the survival rate of patients with ARDS (13).…”
Section: Discussionsupporting
confidence: 93%
“…The pathological analysis revealed that the injury of the experimental group, as well as the inflammation infiltration, were alleviated compared with that of the control group. Although CBP treatment for ARDS patients has not been written in guidelines, its functions such as clearance of inflammatory mediators, suppression of body reaction to pro-inflammation and anti-inflammation, stabilization of hemodynamics, and improvement of organ functions have been reported and adopted many times in the recent decade (9,10,12,14). To summurize, at present, the main mechanisms of blood purification in the treatment of ARDS are ultrafiltration of liquid, maintenance of a low temperature for reduction of oxygen consumption, reduction of extravascular lung water content, and elimination of inflammation factors (15).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, in this process, numerous water-soluble molecules such as tumor necrosis factor α, interleukin (IL)-6, IL-8, and IL-10 are known to play a strategic role [25,26], and neither singlemediator-directed nor one-time intervention seems to be appropriate. Removal of nonspecific proinflammatory or anti-inflammatory mediators by convection and adsorption has been demonstrated during CRRT [27]; therefore, it may be the most logical and adequate approach to a complex and long-running process such as sepsis [26]. Furthermore, the timing of therapeutic intervention seems to be crucial in the septic process.…”
Section: Discussionmentioning
confidence: 99%
“…30 It is widely believed that edema fluid must be cleared for patients with ARDS to survive. [23][24][25][32][33][34][35] Table 4 summarized the studies on the use of CRRT in these ARDS patients associated with the common causes, including sepsis, trauma, postoperative, pancreatitis, pneumonia, etc. Although it has not become a standard protocol for ARDS treatment, using CRRT to support ARDS treatment has been studied and reported in several medical centers for the past decade.…”
Section: Discussionmentioning
confidence: 99%