Can nanotechnology potentiate photodynamic therapy?

Huang, Ying‐Ying; Sharma, Sunil; Chung, Hoon; Yaroslavsky, Anastasia; García-Díaz, María; Chang, Julie; Chiang, Long Y.; Hamblin, Michael R.

doi:10.1515/nano.0034.00008

Cited by 29 publications

(50 citation statements)

References 219 publications

(273 reference statements)

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“…The fact that most effective PSs tend to be insoluble, hydrophobic molecules with a high propensity to aggregate means that encapsulation in nano-drug carriers may make a big difference to their performance [84]. Moreover many other nanostructures such as plasmonic gold nanoparticles, mesoporous silica nanoparticles, carbon nanotubes, graphene and upconversion nanoparticles have found uses in PDT [85]. There is another group of nanostructures where the actual nanoparticle itself acts as the PS absorbing light and producing ROS, as in the case of fullerenes [86], titanium dioxide [84] and some types of quantum dots [87].…”

Section: Nanotechnologymentioning

confidence: 99%

New photosensitizers for photodynamic therapy

Abrahamse

Hamblin

2016

Biochemical Journal

1,669

1,172

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Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases including infections. PDT uses photosensitizers (PSs, non-toxic dyes) that are activated by absorption of visible light to initially form the excited singlet state, followed by transition to the long-lived excited triplet state. This triplet state can undergo photochemical reactions in the presence of oxygen to form reactive oxygen species (including singlet oxygen) that can destroy cancer cells, pathogenic microbes and unwanted tissue. The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery. Tetrapyrrole structures such as porphyrins, chlorins, bacteriochlorins and phthalocyanines with appropriate functionalization have been widely investigated in PDT, and several compounds have received clinical approval. Other molecular structures including the synthetic dyes classes as phenothiazinium, squaraine and BODIPY (boron-dipyrromethene), transition metal complexes, and natural products such as hypericin, riboflavin and curcumin have been investigated. Targeted PDT uses PSs conjugated to antibodies, peptides, proteins and other ligands with specific cellular receptors. Nanotechnology has made a significant contribution to PDT, giving rise to approaches such as nanoparticle delivery, fullerene-based PSs, titania photocatalysis, and the use of upconverting nanoparticles to increase light penetration into tissue. Future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.

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Section: Nanotechnologymentioning

confidence: 99%

New photosensitizers for photodynamic therapy

Abrahamse

Hamblin

2016

Biochemical Journal

1,669

1,172

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“…[73][74][75][76] Over the last decade, numerous nanoparticles have been developed for the in vivo tumor-targeted delivery of imaging agents or drugs. [77][78][79][80] We developed self-assembled HANPs that can be used as the tumor-targeted delivery system of photosensitizers for both photodynamic imaging and photodynamic therapy. [10] Because photosensitizers can simultaneously generate fluorescence for imaging and singlet oxygen for treatment upon irradiation, it may be useful as a theranostic system for combined diagnosis and therapy.…”

Section: Ha-based Nanoparticles For Small Molecular Drug Deliverymentioning

confidence: 99%

Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment

Rao

Yoon

Han

et al. 2015

Expert Opinion on Drug Delivery

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To develop a successful HA-based nanomedicine, it has to be prepared without significant deterioration of intrinsic property of HA. The chemical modification of HA with drugs or hydrophobic moieties may reduce the binding affinity of HA to the receptors. In addition, since the HA-based nanomedicines tend to accumulate in the liver after their systemic administration, new strategies to overcome this issue have to be developed.

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“…In addition, several different PSs can be encapsulated, SiNPs are stable to pH changes, and are not subject to microbial attack. Due to the permeability of the porous matrix to molecular oxygen, singlet oxygen that is generated inside can come out, so the photo-destructive effect can be maintained in an encapsulated form [67]. …”

Section: Photodynamic Inactivation and Nanotechnologymentioning

confidence: 99%

“…There are some instances when the NPs themselves act as the PS in the absence of preformed PS [67]. In this case, the NPs themselves have to be able to absorb light by virtue of possessing an extinction coefficient of appreciable size in an appropriate region of the electromagnetic spectrum and to form an excited state that can lead to some photochemical generation of ROS.…”

Section: Photodynamic Inactivation and Nanotechnologymentioning

confidence: 99%

Advances in antimicrobial photodynamic inactivation at the nanoscale

2017

Self Cite

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The alarming worldwide increase in antibiotic resistance amongst microbial pathogens necessitates a search for new antimicrobial techniques, which will not be affected by, or indeed cause resistance themselves. Light-mediated photoinactivation is one such technique that takes advantage of the whole spectrum of light to destroy a broad spectrum of pathogens. Many of these photoinactivation techniques rely on the participation of a diverse range of nanoparticles and nanostructures that have dimensions very similar to the wavelength of light. Photodynamic inactivation relies on the photochemical production of singlet oxygen from photosensitizing dyes (type II pathway) that can benefit remarkably from formulation in nanoparticle-based drug delivery vehicles. Fullerenes are a closed-cage carbon allotrope nanoparticle with a high absorption coefficient and triplet yield. Their photochemistry is highly dependent on microenvironment, and can be type II in organic solvents and type I (hydroxyl radicals) in a biological milieu. Titanium dioxide nanoparticles act as a large band-gap semiconductor that can carry out photo-induced electron transfer under ultraviolet A light and can also produce reactive oxygen species that kill microbial cells. We discuss some recent studies in which quite remarkable potentiation of microbial killing (up to six logs) can be obtained by the addition of simple inorganic salts such as the non-toxic sodium/potassium iodide, bromide, nitrite, and even the toxic sodium azide. Interesting mechanistic insights were obtained to explain this increased killing.

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Can nanotechnology potentiate photodynamic therapy?

Cited by 29 publications

References 219 publications

New photosensitizers for photodynamic therapy

New photosensitizers for photodynamic therapy

Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment

Advances in antimicrobial photodynamic inactivation at the nanoscale

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