Can NSAID/ASA-induced Erosions of the Gastric Mucosa Be Identified at Histology?

Stolte, Manfred; Panayiotou, Stefani; Schmitz, Jörg

doi:10.1016/s0344-0338(99)80025-9

Cited by 22 publications

(17 citation statements)

References 26 publications

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“…Overall, in the total population studied, use of either aspirin or NSAIDs during the past 3 months was confirmed in 16.9% and antacids, histamine‐2 receptor antagonists and proton pump inhibitors had been taken by 19% 44 . In this population, only 32% of those reported to have taken aspirin had chemical‐reactive gastritis, reportedly a sensitive marker of this drug 45 . No information is available on the use of probiotics in these subjects.…”

Section: Discussionmentioning

confidence: 86%

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Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia

Walker

Talley

Prabhakar

et al. 2009

Aliment Pharmacol Ther

233

218

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SUMMARY Background Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function. Aim To examine mast cell, eosinophil and intraepithelial lymphocyte populations in duodenal biopsies of subjects with IBS and FD. Methods A random sample of an adult Swedish population (n = 1001; mean age 54 years; 51% female) underwent upper endoscopy and biopsy; 51 cases with FD and 41 cases with IBS were compared with 48 randomly selected controls. Eosinophils were identified by light microscopy; mast cells by immunocytochemistry (CD117). Intraepithelial lymphocytes were counted per 100 enterocytes. Cell counts were quantified by counting the number per high power field (HPF) in 5HPFs in the bulb (D1) and second part of duodenum (D2), summed over 5HPFs at each site. Results Cases and controls showed similar demographics. Compared to controls, IELs in IBS-constipation were significantly increased (P = 0.005). Mast cells were significantly increased in IBS in D2 (P < 0.001), while eosinophils were significantly increased in FD in D1 and D2 (P < 0.001). Conclusion Duodenal mast cell hyperplasia is linked to IBS and eosinophilia to FD, and duodenal biopsy may identify subsets of these disorders.

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Section: Discussionmentioning

confidence: 86%

“…44 In this population, only 32% of those reported to have taken aspirin had chemicalreactive gastritis, reportedly a sensitive marker of this drug. 45 No information is available on the use of probiotics in these subjects.…”

Section: Discussionmentioning

confidence: 99%

Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia

Walker

Talley

Prabhakar

et al. 2009

Aliment Pharmacol Ther

233

218

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“…Stolte et al. (13) were able to recognize NSAID‐induced erosions based on their characteristic stromal necrosis.…”

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confidence: 99%

“…always accompanied by an element of acute inflammation, and fibrosis was diagnosed in all the cases. Stolte et al (13) were able to recognize NSAID-induced erosions based on their characteristic stromal necrosis.…”

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confidence: 99%

Histopathology of Gastric Erosions Association with Etiological Factors and Chronicity

et al. 2011

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“…Overexpressions of adhesion molecules, including LFA‐1and ICAM‐1, were reported, and these are thought to play crucial roles in this mechanism 15 ,. 16 Histologically, the specific features of NSAID‐related gastritis are interstitial congestion and oedema in the gastric mucosa without lymphocytic infiltration 17 . It is likely that these features are caused by ischaemia, because the histological features are similar to those of ischaemic colitis.…”

Section: Introductionmentioning

confidence: 99%

The specific expression of Hypoxia Inducible Factor‐1α in human gastric mucosa induced by nonsteroidal anti‐inflammatory drugs

Ito

Tanaka

Kim

et al. 2003

Aliment Pharmacol Ther

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SUMMARYBackground: Hypoxia is a cause of gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The expression of hypoxia inducible factor-1a (HIF-1a) reflects the status of tissue ischaemia. Aim: To investigate the effect of NSAID administration on the expression of HIF-1a in human gastric mucosa. Methods: We employed 71 patients including 14 with NSAID administration. The HIF-1a expression was estimated by immunohistochemistry using monoclonal antibody (H1a67) and raised antiserum (HI-3). Vascular endothelial growth factor expression was also examined by immunohistochemistry. HI-3 recognized hypoxia-induced protein in HeLa cells.

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Can NSAID/ASA-induced Erosions of the Gastric Mucosa Be Identified at Histology?

Cited by 22 publications

References 26 publications

Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia

Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia

Histopathology of Gastric Erosions Association with Etiological Factors and Chronicity

The specific expression of Hypoxia Inducible Factor‐1α in human gastric mucosa induced by nonsteroidal anti‐inflammatory drugs

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