2016
DOI: 10.1016/j.mehy.2016.06.001
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Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?

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Cited by 6 publications
(4 citation statements)
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“…DAPSA is a measure of peripheral PsA activity, which reflects the synovial inflammatory response and includes parameters such as the CRP concentration, tender and swollen joint counts, and patient assessment of disease activity and pain [29]. During periods of pain, there is a greater abundance of proinflammatory mediators [52], which are released into the circulation from the inflamed joints, where they might stimulate innate and adaptive immunity and serve as biological markers of inflammation [53]. Th-1 and Th-17 effectors [54] and MCP-1 [5,20], which are characteristic of PsA, participate in inflammation and pain, lead to increased blood pressure [55,56] and support atherogenesis, especially in patients with metabolic syndrome [54,57], and stimulate organ damage [55].…”
Section: Discussionmentioning
confidence: 99%
“…DAPSA is a measure of peripheral PsA activity, which reflects the synovial inflammatory response and includes parameters such as the CRP concentration, tender and swollen joint counts, and patient assessment of disease activity and pain [29]. During periods of pain, there is a greater abundance of proinflammatory mediators [52], which are released into the circulation from the inflamed joints, where they might stimulate innate and adaptive immunity and serve as biological markers of inflammation [53]. Th-1 and Th-17 effectors [54] and MCP-1 [5,20], which are characteristic of PsA, participate in inflammation and pain, lead to increased blood pressure [55,56] and support atherogenesis, especially in patients with metabolic syndrome [54,57], and stimulate organ damage [55].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, pain is one of the common complaints of postmenopausal women. Pain due to vascular dysfunction caused by decreased estrogen levels in postmenopausal women plays a key role in the development and progression of age-related KOA ( Laskarin et al, 2016 ). Studies suggest that RES supplementation may improve chronic pain in postmenopausal women.…”
Section: Clinical Studies About Res and Its Effects In Koamentioning
confidence: 99%
“…Factors of cardiovascular diseases can affect the progression of OA. The cardiovascular continuum affects the subchondral parts of the tubular bones causing ischemia, inflammation, lipid impregnation [3,4] and remodeling [5,6]. The main role is assigned to the subchondral bone which is involved in the OA pathogenesis [7,8].…”
Section: Introductionmentioning
confidence: 99%