Can Pittsburgh compound B PET imaging quantify demyelination in MS?

Jones, Nick

doi:10.1038/nrneurol.2010.186

Cited by 2 publications

(1 citation statement)

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“…It was found that, in mice, PiB staining was restricted to white matter tracts, labeling deep cerebellum white matter and the corpus callosum. A similar pattern of labeling was observed in postmortem tissue from patients with MS, except that within demyelinating lesions a lack of PiB staining was evident [30,31]. PiB has low specific binding in the cerebellar region [32].…”

Section: Importance Of Early Prediction Of Msmentioning

confidence: 65%

Role of Amyloid from a Multiple Sclerosis Perspective: A Literature Review

Chandra¹

2015

Neuroimmunomodulation

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The traditional concept of multiple sclerosis (MS), that it is primarily a white matter inflammatory disease, has changed a great deal. Thanks to the recent development witnessed in MS research, a whole new idea has emerged that MS is a neurodegenerative disease, and neurodegeneration occurs rather earlier in the pathological process. This has also led to the foundation of the hypothesis that two fundamentally different diseases, Alzheimer's disease (AD) and MS, may share a common mechanism of neurodegeneration. Conventionally, amyloid is thought to be a consequence of protein misfolding and aggregation and is most notorious for its association with debilitating and chronic human diseases. Amyloid is implicated to be related with the deterioration and progression of AD. The finding of amyloid precursor protein expression in axons around the plaque in MS, as well as the correlation of amyloid-β (Aβ) with different stages of MS, has clearly indicated that amyloid plays some kind of key role in MS disease pathogenesis. Excitingly, a paradoxical phenomenon of Aβ has also been observed in several studies recently. It has been shown that amyloid might actually be helping in ameliorating the inflammatory effect in diseases like AD and MS. Amyloid imaging allows earlier diagnosis of MS by taking advantage of the relation of amyloid with MS. This will have a big impact on patient diagnosis and management. In this review I have included the findings of research studies dating from several years back to the most recent ones. Through this review I have tried to show the critical role of amyloid in MS and the importance of investigating through PET imaging.

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Section: Importance Of Early Prediction Of Msmentioning

confidence: 65%

Role of Amyloid from a Multiple Sclerosis Perspective: A Literature Review

Chandra¹

2015

Neuroimmunomodulation

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Synthesis optimization of pittsburgh compound B by the captive solvent method

Clemente

Alves

Abrunhosa

2012

2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG)

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Carbon-11 is a positron emitting nuclide that has been used extensively to label compounds destined for molecular targets in the brain. Pittsburgh compound B ([ 11 C]PiB) is a benzothiazole derivative of thioflavin T that is used to image beta-amyloid deposits in Alzheimer's disease patients with Positron Emission Tomography (PET). In this paper we report on the optimization of a fully automated synthesis, purification and reformulation of [ 11 C]PiB suitable for use in human PET studies. [ 11 C]PiB was prepared from 2-(4'-aminophenyl)-6-hydroxybenzothiazole by [ 11 C]-methylation with methyl triflate reacting in an high-performance liquid chromatography (HPLC) loop, purified and reformulated by solid phase extraction.The specific activity of [ 11 C]PiB was 25 ± 10 GBq/µmol, and radiochemical purity was better than 95%.

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Can Pittsburgh compound B PET imaging quantify demyelination in MS?

Cited by 2 publications

References 1 publication

Role of Amyloid from a Multiple Sclerosis Perspective: A Literature Review

Role of Amyloid from a Multiple Sclerosis Perspective: A Literature Review

Synthesis optimization of pittsburgh compound B by the captive solvent method

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