Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update

Chopra, Aditi; Sivaraman, Karthik; Radhakrishnan, Raghu; Balakrishnan, Dhanasekar; Narayana, Aparna

doi:10.1016/j.jdsr.2021.03.001

Cited by 47 publications

(46 citation statements)

References 64 publications

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“…Several studies have demonstrated the efficacy of antiseptic solution to inactivate SARS-CoV-2 in vitro: J.S. Pelletier et al demonstrated the importance of Povidone-Iodine (PVP-I) for use in the nasal passages, nasopharynx, and oral cavities [ 5 , 23 , 24 , 25 ]. S. Frank et al demonstrated the complete inactivation of SARS-CoV-2 using concentrations of the nasal antiseptic PVP-I as low as 0.5% after 15 s of contact [ 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Ophthalmic Solutions against SARS-CoV-2: A Preventive Action to Block the Viral Transmission?

et al. 2021

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In 2020, a global pandemic was declared following the spread of SARS-CoV-2, the pathogen responsible for COVID-19. The risk of infection is high due to the ease of transmission, which can occur orally, through droplets, or via contact with contaminated surfaces and objects. It has also been demonstrated that the ocular surface can constitute a transmission route, especially in hospital settings, where health care workers can become a dangerous source of infection. In order to increase prevention and reduce the spread of the virus on the ocular surface, the antiviral activity of already-marketed eye drops against SARS-CoV-2 was evaluated. Iodim, Ozodrop, Septavis, and Dropsept were tested against SARS-CoV-2 in plaque-assay experiments at different stimulation times. Furthermore, the expression levels of early and late genes were evaluated through molecular assays. Results indicated that three of the four ophthalmic solutions showed a considerable dose-dependent inhibition of viral replication, highlighting their use as potential antiviral drugs against SARS-CoV-2 and preventing other ocular infections.

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Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Ophthalmic Solutions against SARS-CoV-2: A Preventive Action to Block the Viral Transmission?

et al. 2021

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“…The mouth is potentially involved in the pathophysiological process of COVID-19 (7-10) and oral health could impact the severity of the disease (8,10). Thus, the use of adjuvant preventive measures, such as toothbrushing, gargling, rinsing and oral care products, has been reported (11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Toothbrushing with a dentifrice containing antimicrobial phthalocyanine derivative for the intraoral reduction of viral load of SARS-CoV-2: a pilot study

Poleti

Gregorio

Bistaffa

et al. 2021

Preprint

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Background: The aim of this study was to evaluate the effects of the toothbrushing with a dentifrice containing antimicrobial phthalocyanine derivative (APD) for the intraoral reduction of viral load of SARS-CoV-2.Material and methods: Twenty COVID-19 positive dentate patients were selected and toothbrushes with a dentifrice containing APD for 2 minutes. Self-collected samples of unstimulated saliva were carried out three times: T0 (baseline, before toothbrushing), T5 (5 minutes after toothbrushing), and T30 (30 minutes after toothbrushing). The analysis of RNA viral was performed by RT-PCR using TaqPath™ COVID-19 multiplex Real-Time RT-PCR test for detection of three viral genes (ORF1ab, N and S genes). Evaluation of the effects was based on difference in cycle threshold (Ct) value. Friedman's test and pairwise comparison with Bonferroni corrections were used, with a significance level of 5%. Results: The Ct values were significantly higher (p=0.020) at T30 in comparison to T0 and T5. The greatest difference in the Ct values was between T30 and T0 (3.83). Conclusion: This pilot study suggests that oral hygiene action associated with an antimicrobial chemical dentifrice may be an important tool for SARS-CoV2 viral load reduction in oral cavity.

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“…1. Recent evidence has confirmed that 0.5% povidone iodine (PVP-I) mouthrinse/gargle for 30 s can reduce SARS-CoV-2 virus infectivity to below detectable levels [148,149,151,152,153,154]. 2.…”

Section: In Order To Observe Better Results In Treatment It's Critical To Slow Down the Viral Growth Becausementioning

confidence: 99%

“…3. PVP-I can even interrupt SARS-CoV-2 attachment to oral and nasopharyngeal tissues and lower the viral particles in the saliva and respiratory droplets [148]. 4.…”

Section: In Order To Observe Better Results In Treatment It's Critical To Slow Down the Viral Growth Becausementioning

confidence: 99%

Combinations of drugs might increase the survival chances of COVID-19 patients: Literature review till date

Karthik¹

2021

Preprint

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Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update

Cited by 47 publications

References 64 publications

Inhibitory Effect of Ophthalmic Solutions against SARS-CoV-2: A Preventive Action to Block the Viral Transmission?

Inhibitory Effect of Ophthalmic Solutions against SARS-CoV-2: A Preventive Action to Block the Viral Transmission?

Toothbrushing with a dentifrice containing antimicrobial phthalocyanine derivative for the intraoral reduction of viral load of SARS-CoV-2: a pilot study

Combinations of drugs might increase the survival chances of COVID-19 patients: Literature review till date

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