Can preoperative modified systemic inflammation score (mSIS) be used to predict malignancy in persistent nondiagnostic thyroid nodules?

Ataş, Hakan; Körüklüoğlu, Birol; Çomçalı, Bülent; Yakşi, Neşe; Saylam, Barış; Tez, Mesut

doi:10.3906/sag-2011-177

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Ataş et al concluded that there is a significant relationship between mSIS and malignancy and so it can be used as a marker for making surgical decisions in their 2 separate studies on indeterminate TN and persistent nondiagnostic TN. 23,24 Li et al claims that there is a significant relationship between low alb count and high pdw value and thyroid cancer in their study with platelet distribution width and albumin results. 25 Kocer et al also claims that the N/L ratio could be used as a predictor for TN malignancy in their study examining the relationship between neutrophil/lymphocyte ratio and thyroid cancer.…”

Section: Discussionmentioning

confidence: 94%

Is Modified Systemic Inflammation Score a Predictor of Malignancy in Indeterminate Thyroid Nodules?

Duymaz¹,

Tekın²,

Önder³

et al. 2023

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The aim of this study is to evaluate the preoperative diagnostic value of modified systemic inflammation score (mSIS) in predicting the presence of malignancy in patients with indeterminate thyroid nodules. Material and Methods: It is a retrospective study. Three hundred and sixty eight patients who underwent thyroid lobectomy were screened. Patients were divided into 3 groups according to modified SIS; mSIS 0 for those were albumin (alb) ≥ 4.0 gr/dL and lymphocyte monocyte ratio (LMR) ≥ 3.4, mSIS 1 for those were alb<4.0 gr/dL or LMR<3.4, mSIS 2 for those were alb<4.0 gr/dL and LMR<3.4. According to the results of the postoperative pathology, the patients were divided into two groups as benign and malignant. Results: The malignancy was found in 24 patients in histopathological examination. Ten (41.7%) of these were micropapillary, 8 (33.3%) were papillary, and 6 (25%) were follicular carcinomas. There was no difference between the malignant and benign groups in terms of LMR and albumin values. mSIS 0 had a 65% malignancy rate, mSIS 1 69.2%, and mSIS 2 66.6%. There was no statistically significant difference between the groups. Conclusion: MSIS may not be a predictor of malignancy in indeterminate thyroid nodules. Further studies are needed to understand this issue.

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Section: Discussionmentioning

confidence: 94%

Is Modified Systemic Inflammation Score a Predictor of Malignancy in Indeterminate Thyroid Nodules?

Duymaz¹,

Tekın²,

Önder³

et al. 2023

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“…[26][27][28][29] However, the value of mSIS, for predicting malignancy remains unclear. [30][31][32] Further studies evaluating the SII and mSIS together will help to understand the predictive effect.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Importance of the Systemic Inflammatory Index in Pathologies of the Larynx

TOPUZ,

ZEYBEK SİVAS,

TÜRE

et al. 2023

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This study aimed to determine the prognostic importance of the preoperative systemic immune-inflammatory index (SII) in laryngeal lesions and to investigate its predictive importance compared to the neutrophil-lymphocyte ratio (NLR) and plateletlymphocyte ratio (PLR). Material and Methods: Retrospective comparisons were made between the preoperative blood parameters (NLR, PLR, and SII) and clinicopathological features of 133 patients who underwent surgery for a localized laryngeal lesions between March 01, 2010 and June 31, 2021. Receiver-operating characteristic analysis was used to calculate the cut-off value of the SII. Results: Of the 133 patients with laryngeal lesions, 81 (60.9%) had benign lesions, 20 (15%) had premalignant lesions, and 32 (24.1%) had malignant pathology results. The mean SII value was determined to gradually increase in the order of benign, premalignant, and malignant pathology (444.36; 525.69; 738.07, respectively). A statistically significant difference was found between the SII values of the groups classified as benign, premalignant, and malignant according to laryngeal pathologies (p<0.001). A statistically significant moderate-level correlation of approximately 35% was determined between the benign, premalignant, and malignant pathology results and SII, between the pathology results and NLR at 36%, and with PLR at 29%. Conclusion: A significant relationship was observed between the tendency of the disease and malignancy in laryngeal pathologies and the SII. This significant relationship was also determined by NLR and PLR. In this context, the SII was evaluated as an inexpensive, routine screening test that can be used to evaluate the prognosis of patients with laryngeal pathology.

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The Relation Between Modified Systemic Inflammation Score and Prognostic Markers of Gastrointestinal Stromal Tumors

CANLIKARAKAYA,

OCAKLI,

CEYLAN

et al. 2023

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Objective Gastrointestinal stromal tumours are tumours of mesenchymal origin that can be located along the gastrointestinal tract. In this study, the role of Modified systemic inflammation score in predicting the prognosis of these tumours was investigated. Material and Method 115 patients diagnosed with Gastrointestinal Stromal Tumor (GIST) who underwent surgery at Ankara City Hospital between June 1, 2019 and December 1, 2022 were examined. Tumor location, size, presence of rupture-bleeding-necrosis, Ki-67 level, mitotic index and preoperative albumin, lymphocyte and monocyte levels were evaluated. mSIS score was grouped as 0, 1 and 2. The relationship between mSIS and Ki- 67 index and the presence of rupture, necrosis and bleeding was investigated. Results Out of 115 patients, 68 (59 %) were male, 47 (41 %) were female, with an average age of 62.5 (± 12.67) years. Tumor locations: stomach (64.3 %), small intestine (26 %), colon (5.2 %), esophagus (1.8 %), pancreas (1.8 %), and ovary (0.9 %). Necrosis was in 25 (30.7 %), hemorrhage in 67 (58.7 %), rupture in 19 (16.8 %), and the mean Ki-67 level was 9.09 (± 10.64). 63 (54.8 %) patients had mSIS 0, 29 (25.2 %) had mSIS 1, and 23 (20 %) had mSIS 2. Statistical analysis found a significant correlation between mSIS and necrosis, but not with other parameters. Conclusion The mSIS score is a valuable score showing inflammation in the body and has been shown to be associated with the prognosis of many malignancies. In our study, the presence of necrosis in the tumour was found to be associated with the mSIS score. Although this result alone is not sufficient to predict the prognosis, it is thought to be an issue that may open the door to new studies.

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Can preoperative modified systemic inflammation score (mSIS) be used to predict malignancy in persistent nondiagnostic thyroid nodules?

Cited by 5 publications

References 18 publications

Is Modified Systemic Inflammation Score a Predictor of Malignancy in Indeterminate Thyroid Nodules?

Is Modified Systemic Inflammation Score a Predictor of Malignancy in Indeterminate Thyroid Nodules?

The Prognostic Importance of the Systemic Inflammatory Index in Pathologies of the Larynx

The Relation Between Modified Systemic Inflammation Score and Prognostic Markers of Gastrointestinal Stromal Tumors

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