Antibiotic misuse is common in the United States, but the causes of antibiotic misuse may differ from one health care setting to another. In this commentary, we describe the factors associated with inappropriate antibiotic prescriptions in hospital, outpatient, and long-term care settings, along with specific measures that can help prevent antibiotic misuse.
T he Centers for Disease Control and Prevention (CDC)estimates that up to 50% of all antibiotics prescribed for people are either not needed or are inappropriate [1]. Antibiotic misuse is a major factor in the emergence of multidrug resistant pathogens [2] and is associated with adverse drug reactions, Clostridium difficile infections, and increased health care costs [2].When prescribing an antibiotic, a provider must determine whether the drug is truly indicated in a particular clinical scenario. If so, the provider must consider several factors. The prescribed antibiotic has to be the correct choice for that indication. The dosage, frequency, route of administration, and duration must all be optimal for the prescription to qualify as appropriate. Lastly, the provider must consider drug-drug interactions for the antibiotic prescription to be truly effective and appropriate.In order to improve antibiotic use in a particular setting, efforts have to be directed to the most relevant factors applicable to that setting. The following are descriptions of challenges related to antibiotic misuse and recommendations for prevention in hospital, outpatient, and long-term care settings.