Can Soy Change Serum Estradiol Concentration in Neonate Ovariectomized Rat?

Abstract

Problem statement: Phytoestrogens are plant derived compound found in a wide variety of foods, most notably soy. The purpose of this study was to assess the effect of soy isoflavones on circulating 17-β estradiol in neonate ovariectomized rat. Approach: Thirty, one day olds rats were used. Blood sample were collected after two months. 17-β estradiol was assayed by radioimmuno assay method. Data were analyzed by one way ANOVA and Duncan as post-hoc test. The level of significance was considered p<0.05. Results: Our data showed that ovariectomy significantly (p<0.05) reduced serum 17-β estradiol. Application of soy in doses 0.75 and 1.5 mL kg −1 day −1 following ovariectomy had not significant effect relative to ovariectomy without application of soy, but application of soy in dose 3 mL kg −1 day −1 significantly (p<0.05) increased 17-β estradiol relative to ovariectomy without application of soy. There was no significant difference between dose 3 mL kgday −1 and control and sham group. Conclusion/Recommendation: Our results indicated that soy milk isoflavone can compensate the 17-β estradiol decrease in ovariectomized rat.

The effect of date palm fruit (Phoenix dactylifera L.) on the hormone 17-ß-estradiol in 7,12-dimethylbenz(a)anthracene-induced mammary cancer in rats

“…There is no reference data for the normal concentration of serum E 2 . Additionally, the concentration depends on the hormonal status of the animal (stage of estrous cycle) [12,13], and other external factors to which the animal is exposed such as diet [14,15] and drug treatment(s) [12]. Similar studies -in which E 2 concentration was measuredshowed that the concentration of the hormone in the serum of 15-wk old female SD rats fed AIN-93 G meals was 30.4 pg/ml [16].…”

“…Phytoestrogens compete with the hormone E 2 for estrogen receptors (ERs) and sex hormone binding globulin reducing the hormone availability in neoplastic cells, releasing it out to the circulating system [19]. Additionally, the consumption of isoflavones led to the reduction in the catabolism of estradiol by 24% [19] and compensated for E 2 in ovarectomized rats in a dose dependent manner [15].…”