Can the clinical outcome in state II colon carcinomas be predicted by determination of molecular marker expression?

Abstract

Only Ki-67 and anti-VIII factor were shown to be useful for the prediction of outcome and recurrence rate in curatively treated CC patients. In conjunction with clinical and pathological staging, they may provide a stronger indication of clinical outcome than staging alone and help better select therapeutic options in CC patients.

Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer

“…Our data seem to support the concept of distinct roles for p53 and Bcl-2 in CRC tumorigenesis; while the majority (70%) of carcinomas displayed p53 positivity, the corresponding proportion of positively stained tumors for Bcl-2 was only 46%. This disparity in the observed detection rate is consistent with previous findings (7,9,12,17,20).…”

“…Our observation that such an impact (if any) appears to be staining-dependent (i.e., stronger for tumors with high p53 expression) perhaps explains literature discrepancies on the issue (10,11,14), attributable (in part) to the wide variability in thresholds used to define p53 positivity. Among several studies using different cutoffs and reporting the presence (9,12,18,23) or absence (14,17,20) of a correlation between p53 and stage, only two (17,18) followed the multiple stratification of p53 staining (as we did). Therefore, despite the detected, in that way, significant associations of p53 with either higher stage (18) or poor grade (17), more research is required to determine the clinicopathologically optimal categorization of p53 immunoreactivity.…”

“…p53 expression was additionally scored as negative (<5%), low (5-30%), moderate (31-60%) and high (>60%). This classification was based on previous studies reporting prognostic, clinicopathological and molecular correlations of p53 using these thresholds (7,13,14,(17)(18)(19)(20). A similar categorization for Bcl-2 was deemed inappropriate because of the relatively lower proportion of positive staining (see Results).…”

Reduction of 15‐hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma

“…One possible mechanism by which PGE 2 promotes carcinogenesis is enhancement of cancer cell proliferation. ( 2 ) Previous studies have shown that Ki67 index is correlated with poor prognosis in some types of cancer, ( 38–43 ) although in gastric cancer immunostaining with Ki67 has limited independent value for predicting prognosis, possibly because the prognostic value of Ki67 labeling index in gastric cancer may vary depending on histological type. ( 44 ) Our present study showed that high value of Ki67 labeling index was not associated with an increased probability of gastric cancer–specific mortality in all patients, and in the subgroup of patients with tubular adenocarcinoma Ki67 was associated with cancer‐specific mortality, although it was not independent prognostic factor for poor survival by multivariate analysis.…”

Immunohistochemical and Genetic Prognostic Factors of Neoadjuvant Chemoradiotherapy Efficаcy in Personalized Treatment of Local Advanced Rectal Cancer

“…Clinical trials of Z. Pap et al showed that in adenoma of the large intestine the Ki-67 expression level directly correlates with seriousness of dysplastic changes [22]. Several studies showed that significant Ki-67 expression is mainly connected to lower overal survival rates [23][24][25][26][27], while other studies highlight that high Ki-67 expression correlates with improvement of general survival and better oncological prognosis [28][29][30].…”