Can the Combination of Simvastatin and Melatonin Create a Synergistic Effect on Bone Regeneration?

Koç, Onur; Tüz, Hıfzı Hakan; Ocak, Mert; Bilecenoğlu, Burak; Fırat, Ayşegül; Kaymaz, Fevziye Figen

doi:10.1016/j.joms.2020.12.044

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…In the present study, the fleece collagen membrane was applied, which has been successfully used to transfer NSAIDs to the bone healing area [ 26 ]. The osteogenetic effect of simvastatin has been reported to be greater when it is acting synergistically with other medication such as ezetimibe [ 41 ], hormones [ 42 ] or lasers [ 43 ], while nanofibers have also been lately used to transfer the drug to the affected area [ 41 ]. It appears that its local administration may have a significant impact on bone healing and should be further investigated with the type of carrier that plays a significant role in bone repair induction.…”

Section: Discussionmentioning

confidence: 99%

Effect of Diclofenac and Simvastatin on Bone Defect Healing—An In Vivo Animal Study

et al. 2022

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Non-steroidal, anti-inflammatory drugs and statins are two widely prescribed drug classes that affect bone formation. The aim of this study was to elucidate the effect of diclofenac and simvastatin in artificial bone defect healing. One hundred and forty-four male Wistar rats were used, and the specimens were divided into groups, with respect to the route of drug administration and the type of defect healing (with or without collagen membrane), and subgroups, with respect to the study duration (2, 4 or 8 weeks). Diclofenac was intramuscularly administered while simvastatin was administered both systemically and locally. Animals were euthanized and specimens were histomorphometrically analyzed to evaluate the percentage of new bone formation (%). Bone healing that occurred without any intervention developed more steadily than that of all other groups. Diclofenac exerted a clear, direct inhibitory effect on bone healing and its systemic administration should be avoided. The systemic administration of simvastatin was related to severe myopathy, while the solvent for the local administration of simvastatin seemed to play significant role in bone growth, as simvastatin, when it is administered intraperitoneally in a DMSO solution, appeared to promote bone healing. Local administration may have a significant impact on bone healing and it should be further investigated with the type of solvent or carrier that is used, which both may play a significant role in bone repair induction.

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Section: Discussionmentioning

confidence: 99%

Effect of Diclofenac and Simvastatin on Bone Defect Healing—An In Vivo Animal Study

et al. 2022

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“…These results were also inconsistent with Xue et al, who used a different study model, with a dissimilar site and higher concentration of Sim [ 52 ]. For instance, combining Sim with melatonin and the human allograft showed an improved bone healing capacity after 4 weeks [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Chitosan Nanoparticle/Simvastatin for Experimental Maxillary Bony Defect Healing: A Histological and Histomorphometrical Study

Alsaeed,

Al-Ghaban

2023

Biomimetics

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Biomaterials such as chitosan and simvastatin (Sim) have been introduced to accelerate the extensive and multicellular biological process of bone healing. The aim of this study was to evaluate the bone healing potential of chitosan and Sim, alone or combined. Forty-two male New Zealand rabbits were divided into three groups: chitosan nanoparticles (ChN), Sim and chitosan simvastatin nanoparticles (ChSimN). Two bony defects were created in the maxillary bone. The hole on the right side received one of the experimental materials, while the other side was assigned as the control and left to heal without any intervention. Bone specimens were collected at 2 and 4 weeks and then taken for histological and histomorphometrical analyses. The histological findings revealed that ChN possessed the highest number of osteoblasts and osteoclasts at weeks 2 and osteocytes after 4 weeks. There was a significant difference between the two healing periods regarding all bone parameters across all groups. ChN stood out as the only group that had a significant difference in the count of all bone cells between the two periods, thus having the best potential in promoting bone healing.

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Local Delivery of Melatonin Along With Bone Grafts to Improve Osteogenesis

Ahmadpour,

Azizi,

Behradfar

et al. 2024

Journal of Craniofacial Surgery

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This review is an attempt to investigate the effects of local delivery of melatonin along with bone grafts to improve osteogenesis. A systematic literature search was done from January 1970 to December 2023 using PubMed following PRISMA instructions. A structured search was carried out to identify in vivo and in vitro studies. After screening the articles based on the abstract and title, 24 articles were included. The included studies were animal/human in vivo studies or in vitro studies. In total, 91.7% of the studies reported better outcomes in comparison with the control groups. Melatonin potentially can affect many signaling molecules and pathways promoting osteoblastic differentiation, such as activating pathways including Wnt, Nrf2/HO-1, PI3K/AKT, MAPK, NFkB, SIRT/SOD, BMP/Smad, PERK/ATF4. In conclusion, locally administered melatonin may stimulate bone healing in surgical bone defects and enhance peri-implant bone response.

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Can the Combination of Simvastatin and Melatonin Create a Synergistic Effect on Bone Regeneration?

Cited by 4 publications

References 34 publications

Effect of Diclofenac and Simvastatin on Bone Defect Healing—An In Vivo Animal Study

Effect of Diclofenac and Simvastatin on Bone Defect Healing—An In Vivo Animal Study

Chitosan Nanoparticle/Simvastatin for Experimental Maxillary Bony Defect Healing: A Histological and Histomorphometrical Study

Local Delivery of Melatonin Along With Bone Grafts to Improve Osteogenesis

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