Can the Omicron variant of COVID‐19 cause pneumonia in young patients without risk factors?

Ito, Noriaki; Kitahara, Yoshihiro; Miwata, Kei; Okimoto, Mafumi; Takafuta, Toshiro

doi:10.1002/ccr3.5684

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…Additionally, as new variants of SARS-CoV-2 emerge, most updated scientific evidence should be regularly assessed regarding the risk factors for adverse COVID-19 outcomes. For example, the newest variant called Omicron (B1.1.529), which was declared as a variant of concern by the World Health Organisation (WHO) on 26 November 2021 [ 10 ], has caused severe pneumonia in young patients even without profound risk factors [ 11 ]. Such evidence would be of interest to clinicians to better manage patient flow and to policymakers when planning forthcoming public health measures, such as booster vaccination strategies in coming phases of the pandemic.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe

et al. 2022

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BackgroundAs mortality from coronavirus disease 2019 (COVID-19) is strongly age-dependent, we aimed to identify population subgroups at an elevated risk for adverse outcomes from COVID-19 using age-/gender-adjusted data from European cohort studies with the aim to identify populations that could potentially benefit from booster vaccinations.MethodsWe performed a systematic literature review and meta-analysis to investigate the role of underlying medical conditions as prognostic factors for adverse outcomes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including death, hospitalisation, intensive care unit (ICU) admission and mechanical ventilation within three separate settings (community, hospital and ICU). Cohort studies that reported at least age and gender-adjusted data from Europe were identified through a search of peer-reviewed articles published until 11 June 2021 in Ovid Medline and Embase. Results are presented as odds ratios with 95% confidence intervals and absolute risk differences in deaths per 1000 COVID-19 patients.FindingsWe included 88 cohort studies with age-/gender-adjusted data from 6 653 207 SARS-CoV-2 patients from Europe. Hospital-based mortality was associated with high and moderate certainty evidence for solid organ tumours, diabetes mellitus, renal disease, arrhythmia, ischemic heart disease, liver disease and obesity, while a higher risk, albeit with low certainty, was noted for chronic obstructive pulmonary disease and heart failure. Community-based mortality was associated with a history of heart failure, stroke, diabetes and end-stage renal disease. Evidence of high/moderate certainty revealed a strong association between hospitalisation for COVID-19 and solid organ transplant recipients, sleep apnoea, diabetes, stroke and liver disease.InterpretationThe results confirmed the strong association between specific prognostic factors and mortality and hospital admission. Prioritisation of booster vaccinations and the implementation of nonpharmaceutical protective measures for these populations may contribute to a reduction in COVID-19 mortality, ICU and hospital admissions.

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Section: Introductionmentioning

confidence: 99%

Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe

et al. 2022

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“… 10 Despite a reduction in severity and mortality, patients with persistent high fever were recommended to undergo chest computed tomography (CT). 11 …”

Section: Introductionmentioning

confidence: 99%

“…10 Despite a reduction in severity and mortality, patients with persistent high fever were recommended to undergo chest computed tomography (CT). 11 Concerns about the immune evasion of the Omicron variant have increased. 1,12 Moreover, the possibility of fullvaccination coverage and a booster vaccination was relatively lower in older individuals or in patients with chronic comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Old Age is an Independent Risk Factor for Pneumonia Development in Patients with SARS-CoV-2 Omicron Variant Infection and a History of Inactivated Vaccine Injection

Tong¹,

Huang²,

Zhang³

et al. 2022

IDR

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Objective Analyzing the risk factors for pneumonia development in breakthrough cases with a history of inactivated vaccine injection is important. The present study aimed to investigate the risk factors for pneumonia development during Omicron variant infection. Design and Methods The clinical data were retrospectively collected from 187 patients who previously received inactivated vaccine and were infected by the Omicron variant. Results Among the 187 patients, 73 had 2 doses of inactivated vaccine injection and the remaining 114 had 3 doses; 19 patients had pneumonia at admission. The univariate logistic analysis showed that age, baseline platelet count, D-dimer level, and CD8 + T lymphocyte count were associated with pneumonia development at admission. The multivariate analysis showed that only age was the independent risk factor for pneumonia development (odds ratio = 1.046, 95% confidence interval: 1.003–1.091, P = 0.04). With an optimal cutoff value of 46, 4.4% (4/91) patients in the age <46 years group and 15.63% (15/96) patients in the age ≥46 years group had pneumonia ( χ 2 = 6.454, P = 0.01). Moreover, age negatively correlated with CD8 + T cell count, B cell count, and albumin and uric acid levels (all P < 0.01), while age positively correlated with the glucose level ( P < 0.01). Conclusion Old age was the only independent risk factor for pneumonia development in patients with Omicron variant infection and a history of inactivated vaccine injection.

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“…Additionally, the most recent scientific research about the dangers of COVID-19 should be regularly evaluated when new SARS-CoV-2 variants appear. For instance, the WHO designated the most recent version Omicron (B1.1.529), as a variant of concern on November 26, 2021 8 , which caused severe pneumonia in young patients even without high-risk factors 9 .…”

Section: Introductionmentioning

confidence: 99%

Soetomo COVID-19 Prognostic Score: A Multi-Parametric Model for Early Prediction of Disease Severity of COVID-19 in Tertiery -Resource Hospital

Kurniati,

Utariani,

Syafa’ah

et al. 2024

J Health Sci Med Res

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Objective: Coronavirus disease 2019 (COVID-19) became a global pandemic, with high mortality in severely ill patients. This study aimed to develop a novel scoring system to prognosticate disease severity in COVID-19 patients that is effective and widely available in tertiary medical resource settings.Material and Methods: Laboratory-confirmed COVID-19 patients were enrolled in this retrospective cohort, divided into severe and non-severe groups. We randomly assigned 70% of the subjects to establish a novel scoring system, while the remaining 30% was used for internal validation. The model was constructed by multivariate logistic regression using the first clinical, laboratory, and radiological finding of statistically analysis of group patients. receiver operating characteristic (ROC) and cross-tabulation were used to evaluate the performance of our score and compare it with other models.Results: A total of 599 patients were included. The Soetomo COVID-19 prognostic score predictors included age, fever, specific comorbidities (diabetes, hypertension, cardiac disease, lung tuberculosis), respiratory rate, heart rate, SF ratio, whole blood cell (WBC) count, neutrophil lympocyte ratio (NLR), blood urea nitrogen (BUN), and a RALE score. The area under the ROC of the model indicated an excellent discriminatory ability (training datasets 0.715 [95% CI 0.664-0.767, p-value<0.001]; testing datasets 0.720 [95% CI 0.638-0.802, p-value<0.001]). Our scoring system was superior to both qSOFA and MEWS regarding predictive value. The sensitivity and specificity were 60.6% and 82.5%, respectively.Conclusion: The developed scoring system accurately predicted a significant proportion of severe disease in COVID-19 patients.

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Can the Omicron variant of COVID‐19 cause pneumonia in young patients without risk factors?

Cited by 5 publications

References 2 publications

Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe

Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe

Old Age is an Independent Risk Factor for Pneumonia Development in Patients with SARS-CoV-2 Omicron Variant Infection and a History of Inactivated Vaccine Injection

Soetomo COVID-19 Prognostic Score: A Multi-Parametric Model for Early Prediction of Disease Severity of COVID-19 in Tertiery -Resource Hospital

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