Can TiF4 varnish or TiF4/NaF solution stain eroded and sound enamel?

Mosquim, Victor; Santi, Larissa Rodrigues Pereira; Souza, Beatriz Martines de; Magalhães, Ana Carolina

doi:10.1016/j.jdent.2019.04.006

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…When enamel was submitted to successive erosive challenges, all experimental solutions presented color difference values above the perceptible threshold. Particularly, the negative control group presented values significantly higher than the bioproducts until 10 cycles, which corroborates the observation that the erosion process itself changes the color of specimens [29]. The use of bioproducts on eroded specimens also induced a color difference higher than the perceptibility threshold, leading to an unacceptable outcome for the human eye.…”

Section: Discussionsupporting

confidence: 84%

Pellicle modification with natural bioproducts: Influence on tooth color under erosive conditions

Mailart

Berli

Borges

et al. 2022

European J Oral Sciences

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Salivary pellicle was modified with bioproducts and we assessed the change in tooth color and the protection of enamel to erosion. Human enamel specimens were assigned to one of three solutions: grape seed extract or black tea (bioproducts), or deionized water (negative control); after which one half the specimens underwent erosive challenges. The specimens underwent 15 cycles involving salivary pellicle formation (10 min, 37˚C), incubation in solution (2 min, 25˚C), subsequent pellicle formation (90 min, 37˚C). Half of the specimens was kept in a humid chamber and the other half was submitted to erosion (2 min, 1% citric acid). After 15 such cycles, the pellicle was removed. Tooth color and the surface reflection intensity were assessed after every five cycles and after pellicle removal. For non-eroded specimens, the exposure to bioproducts promoted significantly greater color change than the deionized water, with increases in yellow appearance. After pellicle removal, the color was similar in all non-eroded specimens. The bioproducts increased the surface reflection intensity over cycles. For the erosion-exposed specimens, erosion itself resulted in color change. Black tea and deionized water resulted in increased yellow appearance. Exposure to the bioproducts resulted in higher relative surface reflection intensity values over time, but only grape seed extract resulted in higher relative surface reflection intensity value at the time of pellicle removal. The bioproducts caused transient staining effect, which was reduced after pellicle removal. For enamel submitted to erosion, grape seed extract resulted in less color change and better protection of enamel against erosion than black tea or water.

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Section: Discussionsupporting

confidence: 84%

Pellicle modification with natural bioproducts: Influence on tooth color under erosive conditions

Mailart

Berli

Borges

et al. 2022

European J Oral Sciences

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“…Although, the authors suspect that, as there was no food restriction, it could be possible that the patient's diet may also have been responsible for this glaze's pigmentation and raised another hypothesis related to the titanium reaction with phosphate groups on the tooth's surface with the oxygen atoms, forming a stable titanium dioxide [51]. Corroborating with these authors, Mosquim et al [52] observed that both TIF4 varnish and TIF4/NaF solutions have demonstrated a staining potential with the same magnitude as commercially available NaF varnishes and Elmex ® solution when applied over sound or eroded enamel.…”

Section: Discussionmentioning

confidence: 99%

Research Trends on Preventive and Therapeutic Use of TIF4 for Dental Caries and Erosion

Chevitarese

Leite

Marañón‐Vásquez

et al. 2022

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To evaluate TIF4 preventive and therapeutic use in caries and erosive lesions. Material and Methods: Searches were performed in six databases. Studies evaluating TiF4 use in vitro, in situ, and in vivo in caries and erosive lesions were included and imported into VantagePoint™ (VP). Data about publication year, authors, country, journal, study design, outcomes, TIF4 vehicles, application and intervention time, cariogenic challenge, erosive cycles, effects (positive/ negative /null) and approach (preventive/therapeutic) were analyzed through VP and Excel. Results: 93 published studies were included and an increase in publications was observed between 2010 and 2021. Forty-three authors published three or more articles, of which 67.4% were developed in Brazil and published in Caries Research (22.6%). 69.9% were in vitro studies with erosion assays (59.1%) and with preventive approaches (67.4%). The principal vehicle was a solution (69.9%) with a 1-min single application (58.0%) and with an intervention time of 5-7 days (22.6%). The principal cariogenic challenge in vitro was pH cycling (11.8%); in situ was sucrose + biofilm (6.2%); and in vivo, biofilm (6.2%). The most used erosive cycle was 4× per day in in vitro studies (20.4%) and 1× in vivo (2.1%). A positive effect was observed in prevention (41.9%) and treatment (24.7%) studies. Conclusion: TIF4 has shown a positive effect in prevention and therapeutic treatments for dental caries and erosion.

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“…As varnish is applied every 6 months, the risk of tooth staining is rather low compared with the daily use of a TiF 4 mouthwash. 30 T he benef icia l effect of NaF va r n ish i n remineralization is more often reported for primary teeth than for permanent dentition. 31,32 However, there is still no consensus on the frequency of application (to stop or reverse noncavitated lesions on smooth surfaces), varying the application every 3 to 6 months, 27,33 or using one application per week for 4 consecutive weeks.…”

Section: Discussionmentioning

confidence: 99%

Acceptability and effect of TiF4 on dental caries: a randomized controlled clinical trial

et al. 2021

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This randomized three-armed controlled clinical trial compared the effect of titanium tetrafluoride (TiF 4 ) and sodium fluoride (NaF) varnishes on caries control in smooth surfaces of permanent dentition and children's acceptability. Sixty children (6-8 y/o) were randomly divided into TiF 4 (2.45% F -), NaF (2.26% F -) or placebo (control) groups. Varnishes were applied on permanent teeth once a week for the first 4 weeks and after the 6 th and 12 th months of the study. The variables were as follows: International Caries Detection and Assessment System (ICDAS) scores, quantitative fluorescence changes, visual plaque index (VPI) and degree of acceptability. Two-way RM-ANOVA, ANOVA/Tukey and χ2 tests were performed (p < 0.05). No differences were found between the treatments with respect to ICDAS scores (p = 0.32). Only TiF 4 reduced the mean fluorescence loss significantly at 18 months compared to the baseline (p = 0.003). TiF 4 showed a lower percentage of new caries lesions by tooth surface than the placebo, while NaF did not induce such a change (p < 0.014). Regardless of the treatment, more than 95% of the participants reported being satisfied. For all groups, the VPI decreased significantly at 3 months compared to the baseline value (p < 0.001), with no differences between the treatments (p = 0.17). TiF 4 had a similar ability to control caries lesions as NaF; however, only TiF 4 differed from the placebo (p = 0.004). The acceptability of TiF 4 varnish was similar to that of NaF varnish.

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Can TiF4 varnish or TiF4/NaF solution stain eroded and sound enamel?

Cited by 10 publications

References 21 publications

Pellicle modification with natural bioproducts: Influence on tooth color under erosive conditions

Pellicle modification with natural bioproducts: Influence on tooth color under erosive conditions

Research Trends on Preventive and Therapeutic Use of TIF4 for Dental Caries and Erosion

Acceptability and effect of TiF4 on dental caries: a randomized controlled clinical trial

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