Can vitamin E ester derivatives be excellent alternatives of vitamin E: state of art

Ma, Guangming; Chong, Wenya; Yuan, Quan; Lu, Zeping; Zhang, Zihan; Nian, Binbin; Hu, Yi

doi:10.1007/s00449-023-02918-w

Bioprocess Biosyst Eng

2023

DOI: 10.1007/s00449-023-02918-w

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Can vitamin E ester derivatives be excellent alternatives of vitamin E: state of art

Guangming Ma

Wenya Chong

Quan Yuan

et al.

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2024

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Cited by 3 publications

References 98 publications

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Efficient enzymatic synthesis of vitamin E succinate using an organic solvent‐stable immobilized lipase

Li,

Lin,

Lan

et al. 2024

J Americ Oil Chem Soc

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Vitamin E succinate has gained substantial attention as a potential therapeutic agent for cancer treatment due to its biomedical activities. One of the prominent methods of synthesizing vitamin E succinate is through enzymatic processes, which, although advantageous, presents inherent challenges related to optimization, scalability, and particularly, the poor stability of lipases in organic solvents. Our study addresses these challenges by conducting a comprehensive comparative analysis between Lipase UM1 and three other immobilized commercial lipases, demonstrating Lipase UM1's enhanced resistance to organic solvents and its superior efficiency in vitamin E succinate production. Further optimization experiments with Lipase UM1 led to an unprecedented conversion of 99%. Additionally, we scaled the reaction to a proof‐of‐concept industrial level. The synthesized product was verified using Fourier transform infrared spectroscopy and nuclear magnetic resonance analysis, ensuring its quality and consistency. This study validates Lipase UM1 as an efficient catalyst for vitamin E succinate synthesis, offering a promising avenue for industrial production with potential applications in cancer therapy and beyond.

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Efficient enzymatic synthesis of vitamin E succinate using an organic solvent‐stable immobilized lipase

Li,

Lin,

Lan

et al. 2024

J Americ Oil Chem Soc

View full text Add to dashboard Cite

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A simple and high-performance cellulose nanocrystal based biocatalytic Pickering emulsion system for pharmaceutical molecule vitamin E nicotinate

Wu,

Ou,

Wang

et al. 2024

Carbohydrate Polymers

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Hydrophobic deep eutectic solvents-lipase synergistically catalyze the synthesis of Vitamin E succinate via hydrogen bonds

Ma,

Zhang,

et al. 2024

Journal of Molecular Liquids

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Can vitamin E ester derivatives be excellent alternatives of vitamin E: state of art

Cited by 3 publications

References 98 publications

Efficient enzymatic synthesis of vitamin E succinate using an organic solvent‐stable immobilized lipase

Efficient enzymatic synthesis of vitamin E succinate using an organic solvent‐stable immobilized lipase

A simple and high-performance cellulose nanocrystal based biocatalytic Pickering emulsion system for pharmaceutical molecule vitamin E nicotinate

Hydrophobic deep eutectic solvents-lipase synergistically catalyze the synthesis of Vitamin E succinate via hydrogen bonds

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