Can we model a cognitive footprint of interventions and policies to help to meet the global challenge of dementia?

Rossor, Martin N.; Knapp, Martín

doi:10.1016/s0140-6736(15)60248-3

Cited by 24 publications

(18 citation statements)

References 19 publications

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“…Whilst pharmacological drugs can be used to enhance cognition in healthy individuals and patients with neuropsychiatric disorders, non‐pharmacological strategies are also beneficial (Sahakian et al , ; Savulich et al , ). Well‐established methods to enhance cognition include education and physical exercise (Royal Society, ; Academy of Medical Sciences, ; Erickson et al , ), and there is growing recognition of the importance of a range of lifestyle factors such as diet, sleep and social interaction (Beddington et al , ; Rossor and Knapp, ). There is evidence suggesting that interventions such as learning, exercise and cognitive training activate neural networks in the brain.…”

Section: Pharmacological Cognitive Enhancement In Healthy Peoplementioning

confidence: 99%

Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure

d'Angelo

Savulich

Sahakian

2017

British J Pharmacology

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Today, there is continued, and in some cases growing, availability of not only psychoactive substances, including treatments for mental health disorders such as cognitive enhancers, which can enhance or restore brain function, but also ‘recreational’ drugs such as novel psychoactive substances (NPS). The use of psychoactive drugs has both benefits and risks: whilst new drugs to treat cognitive symptoms in neuropsychiatric or neurodegenerative disorders could have great benefits for many patient groups, the increasing ease of accessibility to recreational NPS and the increasing lifestyle use of cognitive enhancers by healthy people means that the effective management of psychoactive substances will be an issue of increasing importance. Clearly, the potential benefits of cognitive enhancers are large and increasingly relevant, particularly as the population ages, and for this reason, we should continue to devote resources to the development of cognitive enhancers as treatments for neurodegenerative diseases and psychiatric disorders, including Alzheimer's disease, attention deficit hyperactivity disorder and schizophrenia. However, the increasing use of cognitive enhancers by healthy individuals raises safety, ethical and regulatory concerns, which should not be ignored. Similarly, understanding the short‐ and long‐term consequences of the use of NPS, as well as better understanding the motivations and profiles of users could promote more effective prevention and harm reduction measures. Linked ArticlesThis article is part of a themed section on Pharmacology of Cognition: a Panacea for Neuropsychiatric Disease? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.19/issuetoc

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Section: Pharmacological Cognitive Enhancement In Healthy Peoplementioning

confidence: 99%

Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure

d'Angelo

Savulich

Sahakian

2017

British J Pharmacology

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“…). Thus, we are beginning to develop a ‘carbon footprint’ for cognition as we track the presence of healthy and non‐healthy brain factors across the life continuum (Rossor and Knapp ).…”

Section: Resultsmentioning

confidence: 99%

“…Reduction in vascular risk and stroke incidence, healthier lifestyle, and higher education level may be considered factors linked to reduction in dementia over time (Larson et al 2013;Matthews et al 2013;Satizabal et al 2016). Thus, we are beginning to develop a 'carbon footprint' for cognition as we track the presence of healthy and nonhealthy brain factors across the life continuum (Rossor and Knapp 2015).…”

Section: Discussionmentioning

confidence: 99%

Prevention of cognitive impairment: scientific guidance and windows of opportunity

Gorelick

2017

Journal of Neurochemistry

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Cognitive impairment of later life is an important medical and public health challenge. Worldwide it is estimated that the number of persons with dementia will continue to increase, especially in low-and middle-income countries. An important public health challenge relates to the prevention of cognitive decline and dementia. Specifically, is it possible to maintain cognitive vitality or prevent or slow cognitive decline? In this opinion-based piece, I review United States-based guidance statements for maintenance of cognition and select single and multidomain trials designed to preserve cognitive function. Guidance statements now recommend that we treat or prevent cardiovascular risks in hopes of preventing cognitive impairment or decline. I discuss potential gaps between guidance statements and interventional studies, and provide comments on where windows of opportunity may exist to close potential gaps in our quest to maintain cognitive vitality.

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“…The changing global demographics of dementia have led to worldwide predictions of unaffordable treatment and care costs over the coming decades (Rossor and Knapp, 2015). In England, the cost of care is growing (Department of Health, 2012) and there is a need for research to span the artificial divide in health and social care (Alzheimer's Society, 2014).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the effectiveness of different approaches to home support for people in later stage dementia: a protocol for an observational study

Chester

Clarkson

Hughes

et al. 2017

Int. Psychogeriatr.

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Background: Dementia is a major health problem with a growing number of people affected by the condition, both directly and indirectly through caring for someone with dementia. Many live at home but little is known about the range and intensity of the support they receive. Previous studies have mainly reported on discrete services within a single geographical area. This paper presents a protocol for study of different services across several sites in England. The aim is to explore the presence, effects and cost-effectiveness of approaches to home support for people in later stage dementia and their carers.

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Can we model a cognitive footprint of interventions and policies to help to meet the global challenge of dementia?

Cited by 24 publications

References 19 publications

Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure

Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure

Prevention of cognitive impairment: scientific guidance and windows of opportunity

Evaluating the effectiveness of different approaches to home support for people in later stage dementia: a protocol for an observational study

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