Can we rationally design molecularly imprinted polymers?

Nicholls, Ian A.; Adbo, Karina; Andersson, Håkan S.; Andersson, Per Ola; Ankarloo, Jonas; Hedin-Dahlström, Jimmy; Jokela, Päivi; Karlsson, Jesper G; Olofsson, Linus; Rosengren, Jenny; Shoravi, Siamak; Svenson, Johan; Wikman, Susanne

doi:10.1016/s0003-2670(01)00932-1

Cited by 148 publications

(72 citation statements)

References 78 publications

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“…Nicholls [35][36] studied thermodynamic considerations of MIP recognition. He explained that the extent of template complexation at equilibrium is governed by the change in Gibbs free energy of formation of each mode of template-functional monomer interaction.…”

Section: Molecular Recognition Of Mipmentioning

confidence: 99%

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Yan

Row

2006

IJMS

460

231

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Abstract:Molecularly imprinted polymers (MIP) exhibiting high selectivity and affinity to the predetermined molecule (template) are now seeing a fast growing research. However, optimization of the imprinted products is difficult due to the fact that there are many variables to consider, some or all of which can potentially impact upon the chemical, morphological and molecular recognition properties of the imprinted materials. This review present a summary of the principal synthetic considerations pertaining to good practice in the polymerization aspects of molecular imprinting, and is primarily aimed at researcher familiar with molecular imprinting methods but with little or no prior experience in polymer synthesis. The synthesis, characteristic, effect of molecular recognition and different preparation methods of MIP in recent few years are discussed in this review, unsolved problems and possible developments of MIP were also been briefly discussed.

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Section: Molecular Recognition Of Mipmentioning

confidence: 99%

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Yan

Row

2006

IJMS

460

231

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“…A possible explanation for the stability of the GA-AA complex is that a process involving a functional monomer capable of simultaneous interactions of the correct geometry is entropically unfavourable relative to that involving multiple single-point interacting monomers, which yields higher concentrations of the complexed template due to a reduction in the loss of the translational and rotational free energy. Thus, complexes involving simultaneous multiple interactions between the template and functional monomers are more stable due to their thermodynamically favourable structures (Nicholls et al 2001). Hence, GA-AA was more stable due to the formation of two hydrogen-bonding interactions relative to GA-4-Vp where only a single interaction was found to exist.…”

Section: Molecular Modellingmentioning

confidence: 99%

Studies of the Molecular Recognition Abilities of Gallic Acid-Imprinted Polymer Prepared Using a Molecular Imprinting Technique

Pardeshi

Dhodapkar

Kumar

2012

Adsorption Science & Technology

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ABSTRACT:The present work compares the molecular recognition abilities of two molecularly imprinted polymers (MIPs) synthesized using two different functional monomers, viz. acrylamide (AA) and 4-vinylpyridine (4-Vp), employing gallic acid (GA) as the template using the non-covalent imprinting approach employing ethylene glycol dimethacrylate (EGDMA) as the cross-linker and 2,2-azo-bis-2-isobutyronitrile (AIBN) as an initiator in the porogen acetonitrile by thermal polymerization. The change in the electronic stabilization energies (∆E) of the template-monomer complexes formed between the template and functional monomers in the presence of the porogen were computed using Density Functional Theory (DFT) to interpret the nature of the interactions between them and to compare their stabilities. A systematic investigation of the molecular recognition abilities of the synthesized MIPs has been carried out by applying the Langmuir-Freundlich (L-F) adsorption isotherm model. The binding parameters obtained from the L-F model demonstrate that MIP AA exhibited a higher specific molecular recognition ability towards the template molecule.

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“…This is extremely important in order to extend the application of non-covalent molecular imprinting to expensive or poorly soluble template molecules. On the other hand high concentrations of template lead to an increased number of random affinity binding sites, increasing non-specific interactions [31,32].…”

Section: Synthetic Approaches and Design Of Mipsmentioning

confidence: 99%