Can we use the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume values for the diagnosis of anterior uveitis in patients with Behcet’s disease?

Abstract

IntroductionThe purpose of this study was to compare the value of hematological parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), as indicators of anterior uveal segment involvement in patients with Behcet’s disease (BD).Patients and methodsHospital-based records of a total of 912 patients with BD from the dermatology clinic and healthy volunteers from the checkup clinic were assessed retrospectively. After applying the exclusion criteria of the study, 71 of the BD patients with anterior uveitis, 69 of the BD patients without ophthalmological pathology and 151 healthy volunteers were included in the study. MPV, PLR, and NLR values of patients and healthy volunteers were compared.ResultsAll MPV, PLR, and NLR values of patients who had anterior uveitis were significantly higher than those of other patients and healthy volunteers. Statistically, considering area under curves (ratio): NLR was 0.725 (0.653–0.797), P<0.001; PLR was 0.600 (0.523–0.676), P=0.012, and MPV was 0.358 (0.279–0.437), P<0.001.ConclusionMPV, PLR, and NLR are all valuable for assessment of anterior uveal segment involvement in patients with BD. However, the NLR seems to be better than the PLR and MPV for indicating anterior uveitis due to BD.

The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases

“…These parameters can be easily calculated from hemograms based on related indices. Some of the observational studies analyzed in this article have indirectly reflected on shifts in MPV and RDW in inflammation and thrombosis, without drawing conclusions on their predictive values [596165666773]. The main issue is that MPV and platelet distribution width (PDW) are more variable than platelet and other blood cell counts and related ratios [9899], limiting their attractiveness for prospective studies.…”

“…A series of specifically designed adult-cohort studies have examined the values of blood cell ratios in systemic vasculitides, focusing on their associations with clinical manifestations. Three studies have examined shifts in Behçet disease (BD) [656667], which is an autoinflammatory disease with neutrophilic inflammation, predominantly venous thromboses, and other manifestations resembling those of spondyloarthritides and systemic vasculitides [6869]. PLR was not associated with joint, eye, central nervous system, large vessel, or gastrointestinal involvement in BD [65].…”

“…Neither PLR nor NLR was associated with venous thromboses. However, based on ROC curve analyses, NLR was a more informative predictor of anterior uveitis than PLR (AUC, 0.725, 95% CI 0.653–0.797, P <0.001, and AUC, 0.6, 95% CI, 0.523–0.676, P =0.012, respectively) [67]. These results are partly in line with the results of another study that high-lighted the value of NLR as a marker of BD-related inflammatory activity, but not thrombosis [70].…”

Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers

“…NLR has been shown to be associated with prognosis in a large number of malignancies. However, there are studies that showed the value of NLR in inflammatory-infectious conditions such as uveitis, Crohn's disease, sarcoidosis, and tuberculosis [13][14][15][16][17]. CAR is a new inflammatory marker that can be calculated from the results of some routine biochemical blood tests.…”

Dipeptidyl Peptidase-4 Inhibitors and Inflammation: Dpp-4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level

“…MPV is now well known as a predictor of inflammation and has been shown in many cases as a marker of inflammation [17] [18] [19]. In our previous research, we have shown that we can use MPV in the diagnosis of uveitis and venous thrombosis in patients with Behçet's syndrome [20] [21].…”