Canadian Acute Respiratory Illness and Flu Scale (CARIFS) for Clinical Detection of Influenza in Children

Fischer, Jason B.; Prasad, Priya; Coffin, Susan; Mistry, Rakesh D.

doi:10.1177/0009922814542608

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…These features are not dissimilar to clinical characteristics identified in other studies. [34][35][36][37][38] We also found clinical symptoms such as anorexia and arthralgias to be more common in patients with influenza versus other respiratory viruses. However, many of the symptoms associated with influenza were also commonly found in patients with other respiratory viruses or with no respiratory viruses, which speaks to the difficulty of clinical diagnosis in identifying patients with influenza.…”

Section: Discussionmentioning

confidence: 62%

“…However, many of the symptoms associated with influenza were also commonly found in patients with other respiratory viruses or with no respiratory viruses, which speaks to the difficulty of clinical diagnosis in identifying patients with influenza. 34,38 While symptomatic treatment and public health measures in most cases are similar regardless of the type of respiratory virus, the implementation of vaccination and antiviral treatment of influenza makes accurate diagnosis an important consideration in this setting with substantial influenza disease burden.…”

Section: Discussionmentioning

confidence: 99%

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Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka

Shapiro

Bodinayake

Nagahawatte

et al. 2017

The American Society of Tropical Medicine and Hygiene

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In tropical and subtropical settings, the epidemiology of viral acute respiratory tract infections varies widely between countries. We determined the etiology, seasonality, and clinical presentation of viral acute respiratory tract infections among outpatients in southern Sri Lanka. From March 2013 to January 2015, we enrolled outpatients presenting with influenza-like illness (ILI). Nasal/nasopharyngeal samples were tested in duplicate using antigen-based rapid influenza testing and multiplex polymerase chain reaction (PCR) for respiratory viruses. Monthly proportion positive was calculated for each virus. Bivariable and multivariable logistic regression were used to identify associations between sociodemographic/clinical information and viral detection. Of 571 subjects, most (470, 82.3%) were ≥ 5 years of age and 53.1% were male. A respiratory virus was detected by PCR in 63.6% ( = 363). Common viral etiologies included influenza (223, 39%), human enterovirus/rhinovirus (HEV/HRV, 14.5%), respiratory syncytial virus (RSV, 4.2%), and human metapneumovirus (hMPV, 3.9%). Both ILI and influenza showed clear seasonal variation, with peaks from March to June each year. RSV and hMPV activity peaked from May to July, whereas HEV/HRV was seen year-round. Patients with respiratory viruses detected were more likely to report pain with breathing (odds ratio [OR] = 2.60, = 0.003), anorexia (OR = 2.29, < 0.001), and fatigue (OR = 2.00, = 0.002) compared with patients with no respiratory viruses detected. ILI showed clear seasonal variation in southern Sri Lanka, with most activity during March to June; peak activity was largely due to influenza. Targeted infection prevention activities such as influenza vaccination in January-February may have a large public health impact in this region.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka

Shapiro

Bodinayake

Nagahawatte

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…Variables de resultado. Para determinar los efectos clínicos del medicamento, los pacientes fueron evaluados mediante puntuaciones de la escala canadiense de enfermedades respiratorias agudas e influenza (CARI-FS, por sus siglas en inglés), 7 diariamente durante los primeros cinco días. Para la seguridad, se registraron los EA (tipo, gravedad, e intensidad y su posible relación con el tratamiento) acorde con la normatividad vigente en México (NOM-220-SSA1-2016) y la última versión del Diccionario Médico para Actividades Regulatorias (MedDRA, por sus siglas en inglés).…”

Section: Materials Y Métodosunclassified

Efectividad y seguridad de oseltamivir en suspensión en pacientes pediátricos con influenza o enfermedad tipo influenza

Vázquez-Narváez,

Rochín-Kobashi,

García-Robles

et al. 2023

Revista Mexicana De Pediatría

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RESUMENIntroducción: oseltamivir es un potente inhibidor de la neuraminidasa del virus de influenza, que acorta la duración de los síntomas de influenza. Objetivo: describir los resultados clínicos del uso de oseltamivir suspensión en niños con influenza o enfermedad tipo influenza. Material y métodos: estudio clínico, observacional, prospectivo y multicéntrico. Población: niños de dos a 12 años con diagnóstico de influenza o enfermedad tipo influenza que recibieron oseltamivir suspensión (Seltaferon ® ) durante cinco días. Las variables de resultado fueron: evolución clínica (evaluado por escala CARIFS) y la frecuencia de eventos adversos (EA). Resultados: se incluyeron 35 pacientes; promedio de edad, 5.2 ± 2.7 años. Para el día 5, 32 pacientes tuvieron mejoría clínica; en cuanto a seguridad, hubo ocho pacientes en quienes se registraron 18 EA, los cuales fueron leves o moderados. Conclusiones: oseltamivir suspensión es un tratamiento efectivo y seguro en población pediátrica con influenza.

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“…The follow-up visits occurred on days 5 and 7 following treatment initiation. During the medical observation period, the patient diary and the Canadian Acute Respiratory Illness Flu Scale (CARIFS) (26,27) were recorded by the caregivers every 24 hours. In addition, the axillary temperature was measured every 6 hours.…”

Section: Protocolmentioning

confidence: 99%

Efficacy and safety of Qinxiang Qingjie oral solution for the treatment of influenza in children: a randomized, double-blind, multicenter clinical trial

Shen

et al. 2022

Transl Pediatr

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Background: Qinxiang Qingjie (QXQJ), an oral solution containing various Chinese herbs, is indicated for pediatric upper respiratory tract infections. The treatment of influenza also shows potential advantages in shortening the duration of illness and improving symptoms. However, there is still a lack of high-quality clinical evidence to support this. The trial was to explore the efficacy and safety of QXQJ for treating pediatric influenza and provide an evidence-based basis for expanding its applicability.Methods: A randomized, double-blind, double-dummy, positive-controlled, multicenter clinical trial was conducted in 14 hospitals in China. Children aged 1-13 years with influenza and "exterior and interior heat syndromes" as defined by traditional Chinese medicine (TCM) were randomly assigned to two groups with 1:1 radio. Children in the test group received QXQJ oral solution and oseltamivir simulant, while the control group received oseltamivir phosphate granules and QXQJ simulant. The duration of treatment was five days, followed by a two-day follow-up period. The primary endpoint was the clinical recovery time. Secondary endpoints included the time to defervescence, incidences of complications and severe or critical influenza, negative conversion rate, improvement of TCM syndromes, and safety profiles of the therapeutics, which mainly contained the adverse clinical events and adverse drug reactions.Results: A total of 231 children were randomized to either the QXQJ (n=117) or oseltamivir (n=114) group. The FAS and PPS results showed that both groups experienced a median clinical recovery time of three days (P>0.05). The median time to defervescence of both groups were 36 hours in FAS and PPS (P>0.05), and two groups did not differ in terms of the other secondary endpoints (P>0.05). 14 patients (12.39%) in the QXQJ group and 14 patients (12.50%) in the oseltamivir group reported at least one adverse event, respectively. One serious adverse event occurred in the QXQJ group. There was no significant difference in the incidence of adverse events or adverse drug reactions between the groups. Conclusions:The efficacy of QXQJ oral solution was comparable to that of oseltamivir for treating influenza in children, with an acceptable safety profile.

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Canadian Acute Respiratory Illness and Flu Scale (CARIFS) for Clinical Detection of Influenza in Children

Abstract: CARIFS cannot discriminate between FLU and non-FLU infection in ED children with influenza-like infection.

Cited by 7 publications

References 18 publications

Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka

Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka

Efectividad y seguridad de oseltamivir en suspensión en pacientes pediátricos con influenza o enfermedad tipo influenza

Efficacy and safety of Qinxiang Qingjie oral solution for the treatment of influenza in children: a randomized, double-blind, multicenter clinical trial

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