Cancellous Allograft versus Autologous Bone Grafting For Repair of Comminuted Distal Radius Fractures: A Prospective, Randomized Trial

Rajan, Gunesh; Fornaro, Jürgen; Trentz, O.; Zellweger, René

doi:10.1097/01.ta.0000195977.18035.40

Cited by 87 publications

(56 citation statements)

References 33 publications

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“…[8,9] Current bone regeneration methods utilize biological or synthetic grafts, including autografts, allografts, or xenografts, but their wider application is limited by histocompatibility issues, restricted supplies, and the requirement for a secondary surgery. [10][11][12][13] To sidestep some of these issues, a number of studies have explored synthetic alternatives, because they have unlimited availability and do not risk disease transmission from a donor.…”

mentioning

confidence: 99%

Reconstruction of a Rabbit Ulna Bone Defect Using Bone Marrow Stromal Cells and a PLA/β‐TCP Composite by a Novel Sintering Method

et al. 2009

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Bioceramic, synthetic, and natural polymers associated with cell adhesion and growth, have been used as matrices for bone tissue engineering. Successful bone regeneration depends on cellular interaction with these matrices. The purpose of this study was to fabricate polylactic acid (PLA)/ b-tricalcium phosphate (b-TCP) composites with a novel sintering method in order to enhance cellular interaction with matrices for bone regeneration. We prepared the composite by pressing and thermal treatment of the mixture of PLA, b-TCP, and NaCl, after which we seeded bone marrow stromal cells (BMSCs) on the PLA/b-TCP composite scaffolds and either cultured them in vitro or subcutaneously implanted them into nude mice. Also, we examined enhanced bone regeneration in the rabbit defect model. The BMSCs more effectively formed bone-like structures on the PLA/b-TCP composite scaffolds compared to scaffolds containing PLA alone. In addition, fabricating the PLA/b-TCP composite scaffolds using our novel sintering method, instead of a conventional solvent casting method, significantly enhanced alkaline phosphatase activity and calcium deposition in the new bone tissue. We confirmed this enhanced bone regeneration in the rabbit defect model using representative radiography and histological studies. We propose that the superior bone-forming characteristics of PLA/b-TCP cell-composite constructs prepared by our novel sintering method may result from greater surface exposure of the b-TCP particles, which may yield higher osteogenic and osteoconductive properties. This study revealed that generating biodegradable and osteogenic PLA/ b-TCP cell-composite constructs with our novel sintering method could significantly enhance bone regeneration and may be useful for bone tissue engineering.

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confidence: 99%

Reconstruction of a Rabbit Ulna Bone Defect Using Bone Marrow Stromal Cells and a PLA/β‐TCP Composite by a Novel Sintering Method

et al. 2009

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“…Rajan and colleagues treated 75 patients with comminuted distal radius fractures with either autograft or allograft. 6 Clinical and radiographic outcomes 1 year following surgery were similar in both groups. Ring and colleagues treated 35 patients with autografts and plate fixation for diaphyseal forearm nonunions and segmental defects.…”

Section: Clinical Outcomes Autograftmentioning

confidence: 61%

“…7 The most common complication is postoperative pain at the donor site, occurring in 50% of patients and persisting through 1 year in up to 29% of patients. 5,6 Additional commonly reported problems include nerve injury, hemorrhage, fracture, and hernia. [25][26][27][28] Due to this significant morbidity, autologous bone grafting …”

Section: Clinical Outcomes Autograftmentioning

confidence: 99%

“…[4][5][6][7] Complications such as superficial nerve damage, vascular injury, iliac fracture, infection, and chronic donor site pain occur in 10% to 50% of patients who undergo autograft harvest. 5,6 Furthermore, the quantity of bone available for harvest from the iliac crest is limited and regeneration of the residual defect is slow, 8 which hinders the widespread use of this treatment option, particularly for large osseous defects. Overall, the unacceptably high complication risk and prolonged procedure time associated with autograft harvesting has caused skepticism about this graft material among patients and physicians alike.…”

Section: Introductionmentioning

confidence: 99%

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Perspectives on the clinical utility of allografts for bone regeneration within osseous defects: a narrative review

Miller¹,

Block²

2011

ORR

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A variety of bone grafts and bone graft substitutes is available for treatment of osseous defects although adequate reconstruction of the residual void following fracture, arthroplasty, or tumor/cyst resection remains a therapeutic challenge. This narrative review evaluates the peer-reviewed literature and examines relevant outcomes in patients treated with bone grafts and bone graft substitutes for surgical management of osseous defects. Although autograft, xenograft, and ceramic bone graft substitutes are used for a variety of orthopedic applications, they have distinct limitations in clinical practice. Bone allograft material is a safe and effective adjunct to treatment of osseous defects.

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“…Autologous bone grafting is widely accepted as the gold standard for bone repair and regeneration because of the osteogenicity of autologous bone [1], but the insufficient amount of donor tissue and associated donor site pain and morbidity motivate the search for a better approach to repairing bone defects [2,3]. Towards this goal, synthetic materials have been extensively studied as potential autograft substitutes [4,5].…”

Section: Introductionmentioning

confidence: 99%

Porous biphasic calcium phosphate ceramics coated with nano-hydroxyapatite and seeded with mesenchymal stem cells for reconstruction of radius segmental defects in rabbits

Yang

Zhou

et al. 2015

J Mater Sci: Mater Med

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The osteoconduction of porous biphasic calcium phosphate (BCP) ceramics has been widely reported. In a previous study, we demonstrated that applying a nano-hydroxyapatite (nHA) coating enhances the osteoinductive potential of BCP ceramics, making these scaffolds more suitable for bone tissue engineering applications. The aim of the present study was to determine the effects of reconstructing radius defects in rabbits using nHA-coated BCP ceramics seeded with mesenchymal stem cells (MSCs) and to compare the bone regeneration induced by different scaffolds. Radius defects were created in 20 New Zealand rabbits, which were divided into four groups by treatment: porous BCP ceramics (Group A), nHA-coated porous BCP ceramics (Group B), porous BCP ceramics seeded with rabbit MSCs (Group C), and nHA-coated porous BCP ceramics seeded with rabbit MSCs (Group D). After in vitro incubation, the cell/scaffold complexes were implanted into the defects. Twelve weeks after implantation, the specimens were examined macroscopically and histologically. Both the nHA coating and seeding with MSCs enhanced the formation of new bone tissue in the BCP ceramics, though the osteoinductive potential of the scaffolds with MSCs was greater than that of the nHA-coated scaffolds. Notably, the combination of nHA coating and MSCs significantly improved the bone regeneration capability of the BCP ceramics. Thus, MSCs seeded into porous BCP ceramics coated with nHA may be an effective bone substitute to reconstruct bone defects in the clinic.

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Cancellous Allograft versus Autologous Bone Grafting For Repair of Comminuted Distal Radius Fractures: A Prospective, Randomized Trial

Cited by 87 publications

References 33 publications

Reconstruction of a Rabbit Ulna Bone Defect Using Bone Marrow Stromal Cells and a PLA/β‐TCP Composite by a Novel Sintering Method

Reconstruction of a Rabbit Ulna Bone Defect Using Bone Marrow Stromal Cells and a PLA/β‐TCP Composite by a Novel Sintering Method

Perspectives on the clinical utility of allografts for bone regeneration within osseous defects: a narrative review

Porous biphasic calcium phosphate ceramics coated with nano-hydroxyapatite and seeded with mesenchymal stem cells for reconstruction of radius segmental defects in rabbits

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