Cancer as an ecomolecular disease and a neoplastic consortium

Cajal, Santiago Ramón y; Capdevila, Claudia; Hernández-Losa, Javier; Mattos-Arruda, Leticia De; Ghosh, Abhishek; Lorent, Julie; Larsson, Ola; Aasen, Trond; Postovit, Lynne-Marie; Topisirović, Ivan

doi:10.1016/j.bbcan.2017.09.004

Cited by 16 publications

(14 citation statements)

References 138 publications

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“…In the last years, several promising, interdisciplinary approaches have been developed to translate an ecological perspective into research and clinical practices. For instance, in the case of cancer, increasing studies suggest how it should be considered as a multifactorial disease [44,45]. This is due to the fact that a large number of endogenous and exogenous factors (such as diet, exposure to certain environments, lifestyles) and their peculiar (most of the time personalized ) combination, can give rise to the conditions for the development of the disease.…”

Section: Microbiota and Health: The Ecological Perspective And Newmentioning

confidence: 99%

“…In this respect, immunotherapy represents a promising action line. However, if the microbiota is actually considered as a functional part of the immune system itself and thus, the immune response is a network-based, environmental feature, the ecological perspective becomes central in analyzing the immune response in the tumour microenvironment [45]. Moreover, if we embrace a network perspective on health (such as the holobiont view) the distinction of exogenous and endogenous becomes less neat and less sharp.…”

Section: Microbiota and Health: The Ecological Perspective And Newmentioning

confidence: 99%

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I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine

Amedei

Boem

2018

IJMS

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In recent years, the human microbiota has gained increasing relevance both in research and clinical fields. Increasing studies seem to suggest the centrality of the microbiota and its composition both in the development and maintenance of what we call “health” and in generating and/or favoring (those cases in which the microbiota’s complex relational architecture is dysregulated) the onset of pathological conditions. The complex relationships between the microbiota and human beings, which invest core notions of biomedicine such as “health” and “individual,” do concern not only problems of an empirical nature but seem to require the need to adopt new concepts and new perspectives in order to be properly analysed and utilized, especially for their therapeutic implementation. In this contribution we report and discuss some of the theoretical proposals and innovations (from the ecological component to the notion of polygenomic organism) aimed at producing this change of perspective. In conclusion, we summarily analyze what impact and what new challenges these new approaches might have on personalized/person centred/precision medicine.

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Section: Microbiota and Health: The Ecological Perspective And Newmentioning

confidence: 99%

Section: Microbiota and Health: The Ecological Perspective And Newmentioning

confidence: 99%

I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine

Amedei

Boem

2018

IJMS

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“…In fact, the cooperation between clones and the microenvironment is similar to that of a tumor consortium ( Fig. 1) [4]. The new genetic alterations are driven by genetic instability, one of the hallmarks of tumor cells [5].…”

Section: Clonal Evolution During Cancer Progressionmentioning

confidence: 85%

Beyond molecular tumor heterogeneity: protein synthesis takes control

et al. 2018

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One of the daunting challenges facing modern medicine lies in the understanding and treatment of tumor heterogeneity. Most tumors show intra-tumor heterogeneity at both genomic and proteomic levels, with marked impacts on the responses of therapeutic targets. Therapeutic target-related gene expression pathways are affected by hypoxia and cellular stress. However, the finding that targets such as eukaryotic initiation factor (eIF) 4E (and its phosphorylated form, p-eIF4E) are generally homogenously expressed throughout tumors, regardless of the presence of hypoxia or other cellular stress conditions, opens the exciting possibility that malignancies could be treated with therapies that combine targeting of eIF4E phosphorylation with immune checkpoint inhibitors or chemotherapy.

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“…The tumour microenvironment, whether at the primary or secondary sites, is key to tumour cell survival and tumour progression [ 134 ]. In agreement with the hypothesis that Cxs control the microenvironment, Cx43-transfected glioma cells, which formed GJs with astrocytes in the striata of rats, were able to disseminate throughout the brain parenchyma.…”

Section: Connexins and Pannexins: Involvement In Tumour Metastasismentioning

confidence: 99%

Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics

Graham

Jiang

Mesnil

2018

IJMS

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Since their characterization more than five decades ago, gap junctions and their structural proteins—the connexins—have been associated with cancer cell growth. During that period, the accumulation of data and molecular knowledge about this association revealed an apparent contradictory relationship between them and cancer. It appeared that if gap junctions or connexins can down regulate cancer cell growth they can be also implied in the migration, invasion and metastatic dissemination of cancer cells. Interestingly, in all these situations, connexins seem to be involved through various mechanisms in which they can act either as gap-junctional intercellular communication mediators, modulators of signalling pathways through their interactome, or as hemichannels, which mediate autocrine/paracrine communication. This complex involvement of connexins in cancer progression is even more complicated by the fact that their hemichannel function may overlap with other gap junction-related proteins, the pannexins. Despite this complexity, the possible involvements of connexins and pannexins in cancer progression and the elucidation of the mechanisms they control may lead to use them as new targets to control cancer progression. In this review, the involvements of connexins and pannexins in these different topics (cancer cell growth, invasion/metastasis process, possible cancer therapeutic targets) are discussed.

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Cancer as an ecomolecular disease and a neoplastic consortium

Cited by 16 publications

References 138 publications

I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine

I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine

Beyond molecular tumor heterogeneity: protein synthesis takes control

Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics

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