Cancer-associated immune cells and their modulation by melatonin

Hekmatirad, Shirin; Moloudizargari, Milad; Fallah, Marjan; Rahimi, Atena; Poortahmasebi, Vahdat; Asghari, Mohammad Hossein

doi:10.1080/08923973.2023.2239489

Cited by 2 publications

(1 citation statement)

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“…It is commonly utilized for the prevention of jet lag and for the restoration of circadian rhythms. In recent years, several studies have shed light on the possible interaction between melatonin and immunity [27,28]. The pineal gland and melatonin are part of a two-way communication circuit between the neuroendocrine system and the immune system.…”

Section: The Role Of Melatonin In the Hypothalamic Control Of Reprodu...mentioning

confidence: 99%

Role of Melatonin in Ovarian Function

Basini,

Grasselli

2024

Animals

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Melatonin is a hormone mainly produced by the pineal gland in the absence of light stimuli. The light, in fact, hits the retina, which sends a signal to the suprachiasmatic nucleus, which inhibits the synthesis of the hormone by the epiphysis. Mostly by interacting with MT1/MT2 membrane receptors, melatonin performs various physiological actions, among which are its regulation of the sleep–wake cycle and its control of the immune system. One of its best known functions is its non-enzymatic antioxidant action, which is independent from binding with receptors and occurs by electron donation. The hormone is also an indicator of the photoperiod in seasonally reproducing mammals, which are divided into long-day and short-day breeders according to the time of year in which they are sexually active and fertile. It is known that melatonin acts at the hypothalamic–pituitary–gonadal axis level in many species. In particular, it inhibits the hypothalamic release of GnRH, with a consequent alteration of FSH and LH levels. The present paper mainly aims to review the ovarian effect of melatonin.

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Section: The Role Of Melatonin In the Hypothalamic Control Of Reprodu...mentioning

confidence: 99%