Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Jurdana, Mihaela

doi:10.2478/v10019-009-0007-y

Cited by 11 publications

(6 citation statements)

References 56 publications

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“…In addition, it has been widely demonstrated that resistance training enhances the rate of mixed muscle protein synthesis in older participants guarantying an effective muscle proteins turnover and reducing muscle wasting (55,56,57). Moreover, several studies agree with the idea that physical activity can exerts important functions against many other age-related markers improving the general adaptive response of specific anti-oxidant and stress proteins (58).…”

Section: Exercise As a Tool To Counteract Sarcopenia And Cancer-relatsupporting

confidence: 50%

The role of physical activity in counteracting age-related sarcopenia and cancer cachexia: A brief literature review

Scalabrin¹,

Caporossi²

2016

Medicinski podmladak

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Muscle tissue plays several important health functions . In addition to the important mechanical functions, it represents the biggest reserve of body proteins and it is also able to produce several myokines that are able to induce important beneficial effects, through the interaction with different organs. The loss of muscle mass has a tremendous impact on health and it is not surprising that a great interest has raised on two degenerative, irreversible and unstoppable conditions known as sarcopenia and cachexia. Sarcopenia, the age-related loss of muscle mass, is not a disease or a syndrome, it is not even a medical sign sometimes. Indeed, a general consensus among scientists does not exist regarding the definition and the identification criteria of this condition. On the other hand, cachexia is a wasting syndrome characterized by an uncontrolled and unstoppable loss of muscle mass, associated with fatigue and weakness. It is often associated with a disease like cancer, AIDS, Chronic Obstructive Pulmonary Disease (COPD), multiple sclerosis, tuberculosis etc. Given the complexity of these muscle conditions and considering that during aging and cancer there is an increased risk of comorbidities, regular physical activity might be a crucial point to be carefully evaluated on a single patient basis. The aim of this review is to highlight the impact on society and the etiology of sarcopenia and cancer cachexia, with particular regard to the role played by physical activity in preventing and counteracting these muscle-wasting conditions, focusing attention also on the limitation factors that must be considered during the prescription of physical activity to sarcopenic and cachectic patients. Key words: Sarcopenia, Cachexia, Muscle Tissue, Muscle Wasting, Physical Activity, Aging, Cancer. SažetakMišićno tkivo ima nekoliko važnih uloga po ljudsko zdravlje. Pored značajne mehaničke funkcije, ono predstavlja i najveći depo telesnih proteina. Osim toga, proizvodi i nekoliko miokina koji su, kroz interakcije sa drugim organima, u stanju da indukuju veoma bitne efekte. Gubitak mišićne mase ima izuzetan uticaj na zdravlje i ne iznenađuje činjenica da se sve više pažnje obraća na dva degenerativna, ireverzibilna i nezaustavljiva stanja, poznatija kao sarkopenija i kaheksija. Sarkopenija, starosno zavisan gubitak mišićne mase, nije ni bolest ni sindrom, čak nekada nije ni medicinski znak. Konsenzus naučnika zapravo nije utemeljio preciznu definiciju, kao ni kriterijume u vezi sa ovim stanjem. S druge strane, kaheksija predstavlja sindrom gubitka i karakteriše je nekontrolisan i nezaustavljiv gubitak mišićne mase, povezan sa umorom i slabošću. Često je povezana sa bolestima kao što su sindrom stečene imunodeficijencije (fr. syndrome d'immunodéficience acquise, SIDA), hronična opstruktivna bolest pluća (HOBP), multipla skleroza, tuberkuloza itd. Imajući u vidu kompleksnost ovih stanja povezanih sa mišić-nom masom, kao i činjenicu da je tokom starenja i u slučaju karcinoma povećan rizik od komorbiditeta, smatra se da redo...

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Section: Exercise As a Tool To Counteract Sarcopenia And Cancer-relatsupporting

confidence: 50%

The role of physical activity in counteracting age-related sarcopenia and cancer cachexia: A brief literature review

Scalabrin¹,

Caporossi²

2016

Medicinski podmladak

View full text Add to dashboard Cite

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“…We decided to check BMI regularly in OSCC patients because of the known fact that cachexia-anorexia syndrome occurs in 30 to 80% of cancer patients. 72 Although BMI did not reach the malnutrition level it still points to the need of an even better nutritional support of these patients.…”

Section: Discussionmentioning

confidence: 99%

Influence of surgical treatment and radiotherapy of the advanced intraoral cancers on complete blood count, body mass index, liver enzymes and leukocyte CD64 expression

Dovšak¹,

Ihan²,

Didanović³

et al. 2009

Radiology and Oncology

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“…The strong relationship between the hypothalamus and total energy balance of the organism both in the physiological and pathological situations, in particular in relation to body weight, includes also a neuroregulatory component. [15][16][17][18] 3.…”

Section: Pathogenesis Of Tumour Cachexiamentioning

confidence: 99%

Disease specific substrates in cancer cachexia – Reality and anticipation

Zadák

Tichá

Hyšpler

2013

Reports of Practical Oncology & Radiotherapy

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In recent years, the concept of nutrition in patients with tumour diseases has been changing very significantly. The article discusses the pathogenesis of tumour cachexia and sarcopenia, which have been intensively studied, particularly in the last ten years. The possibilities and modern approaches in nutritional support in oncology are reviewed with a special emphasis on the group of elderly patients. Also, a detailed list of the most frequently used pharmaconutrients in oncology is presented. The recommendations for nutritional care of elderly oncological patients are given and discussed.

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Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Abstract: Background. Cachexia-anorexia syndrome is a common and important indicator of cancer. It occurs in

Cited by 11 publications

References 56 publications

The role of physical activity in counteracting age-related sarcopenia and cancer cachexia: A brief literature review

The role of physical activity in counteracting age-related sarcopenia and cancer cachexia: A brief literature review

Influence of surgical treatment and radiotherapy of the advanced intraoral cancers on complete blood count, body mass index, liver enzymes and leukocyte CD64 expression

Disease specific substrates in cancer cachexia – Reality and anticipation

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