Cáncer de la vesícula biliar. Análisis preliminar del programa GES para prevención de esta enfermedad

Gallstones, Body Mass Index, C‐Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

“…We used two-sample MR with genetic variantsspecifically, single-nucleotide polymorphisms-as instrumental variables to investigate the causal effects on the risk of GBC exerted by (1) risk factors considered in the current Chilean GBC prevention program (gallstone disease, BMI, and age at menarche) and ( 2) CRP level as a marker of chronic inflammation. (9,17,18) Summary statistics on the association between the genetic variants and GBC risk adjusted for age, gender, and the first five genetic principal components were obtained using our own demographic and genotype data from the retrospective Chilean (277 cases, 2107 controls) and the prospective European (103 cases, 168 controls) study (Supporting Table S1). Summary statistics on the association between the genetic variants and the risk factors were retrieved from the studies listed in Table 1, while detailed information on the original genetic association analyses including investigated phenotypes, association models and covariates, and analysis tools is provided in the Supporting Methods.…”

“…(17) Each year 50,000 gallbladders are removed in Chile, at an average cost of $1,000 per cholecystectomy, in the framework of this prevention policy. (18) GBC is rare in most countries, and publicly available genotype data from genetic association studies are sparse. We conducted a retrospective Chilean (277 patients, 2,107 controls) and a prospective European (103 cases, 168 controls) study on GBC and applied Mendelian randomization (MR) to investigate the causal relationship between risk factors considered in the current Chilean GBC prevention program, CRP concentration as a marker of chronic inflammation, and GBC risk.…”

Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia

“…In Chile, where GBC represents the third cause of cancer death in women, cholecystectomy is indicated as a preventive strategy to reduce GBC rates in all adults aged between 35 and 49 years with cholecystolithiasis [28]. Although preventive cholecystectomy has been readily implemented in Chile since 2006, there has been sustained decrease in GBC mortality since earlier in 2000 [29]. Therefore, it seems that reduction in GBC mortality may be due to additional factors aside from cholecystectomy.…”