Cancer Death Risk Related to Radiation Exposure from Computed Tomography Scanning Among Testicular Cancer Patients

Abstract

Patient radiation exposure in CT imaging is associated with the type of CT device and imaging protocols, which should be periodically updated and reviewed to minimize individual exposure. Using the UNSCEAR modelling 2 % risk for radiation related cancer death was attributed to diagnostic exposure of study patients. Age at the diagnosis was associated with CT imaging related radiation exposure. The highest exposure was estimated to the youngest patients.

Biological effective dose, cumulative radiation dose, risk of malignancy and mortality rate estimation in adult patients who have a history of cancer and exposed to recurrent computed tomography

“…In the current study, the risk of malignancy was estimated by life attributed risk that ranges from one per 285 to one per 40 depending on cumulative radiation dose measure per three years. Half of our patients have life attributed risk of malignancy 0.5%-1.2% which is equal to 1:200-1:100 & mortality rate from fatal cancer 0.3%-0.6% which is close to the results of many studies (Aaron, 2013, Salminen et al, 2017, Aaron, 2009. According to age & gender-adjusted risk categories that reported by EEIR 7(NRC, 2006) more than half of our patients, 29(58%) were in category 3b (incidence of cancer 1/100) which exceeds the maximum allowed dose level that the worker in the radiological field may expose annually.…”

“…Cancer is the 2 nd most common cause of death in the world (second only to cardiovascular disease), many study concentrated on patients how had history of cancer & undergo multiple CT scan for diagnosis, staging & follow up recurrence of tumor in order to estimate the risk to have further malignancy as the patients exposed to ionizing radiation from medical imaging (Brendon et al, 2011;Salminen et al, 2017;IARC, 2011). Female percent was the higher in our result (74%) as breast cancer was at the 1 st of the list (42%) which goes with Mary C et al who reported that breast cancer is the most commonly diagnosed cancer in the women (Lord, 2017).…”

Data on the estimating the risk of cancer due to some common radiographs in Tehran city

“…Data on the cumulative effective dose for eight radiographs using of scientific relationships based on the acceptance of linear no-threshold model were obtained. Then, the risk of excessive cancer for each radiography was determined by standard equations [6] , [7] .…”

Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study

“…Genome wide association studies (GWAS) have uncovered some candidate genetic loci involved in testicular cancer susceptibility (10-13) and study of single nucleotide polymorphisms (SNPs) in the same loci showed the risk variants which predispose to both familial and bilateral TGCT, which accounted for only 11-16% of the risk for the disease (14). Various external stressors, including diagnostic procedures, contribute to TGCT pathogenesis (15). A pilot study suggests a possible familial TGCT susceptibility that may be associated with promoter methylation in previously identified TGCT risk genes in GWA studies (16).…”