Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle

Zeng, Chaoting; Shang, Wenting; Liang, Xiaoyuan; Liang, Xiao; Chen, Qingshan; Chi, Chongwei; Du, Yang; Fang, Chihua; Hui, Hui

doi:10.1021/acsami.6b06883

Cited by 73 publications

(50 citation statements)

References 56 publications

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“…Xenografted nude mice treated with modified gold nanospheres after NIR laser exposure displayed a significant reduction in the tumor volume and facilitated distinct visualization of tumor tissue in vivo. The ICG loaded mesoporous silica core of the nanoparticles not only allowed potential tumor imaging ability, but also increased the heating efficiency of the gold metal, thus helping to facilitate NIR based image-guided PTT [55]. Kang et al conjugated NIR fluorophore cyptate to hollow gold nanospheres (HGNs) by a urokinase-type plasminogen activator (uPA a breast cancer enzyme) enzyme- substrate motif.…”

Section: Imaging and Photo-thermal Therapy Using Gold Nanoparticlesmentioning

confidence: 99%

Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation

Vats

Mishra

Baghini

et al. 2017

IJMS

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The unresolved and paramount challenge in bio-imaging and targeted therapy is to clearly define and demarcate the physical margins of tumor tissue. The ability to outline the healthy vital tissues to be carefully navigated with transection while an intraoperative surgery procedure is performed sets up a necessary and under-researched goal. To achieve the aforementioned objectives, there is a need to optimize design considerations in order to not only obtain an effective imaging agent but to also achieve attributes like favorable water solubility, biocompatibility, high molecular brightness, and a tissue specific targeting approach. The emergence of near infra-red fluorescence (NIRF) light for tissue scale imaging owes to the provision of highly specific images of the target organ. The special characteristics of near infra-red window such as minimal auto-fluorescence, low light scattering, and absorption of biomolecules in tissue converge to form an attractive modality for cancer imaging. Imparting molecular fluorescence as an exogenous contrast agent is the most beneficial attribute of NIRF light as a clinical imaging technology. Additionally, many such agents also display therapeutic potentials as photo-thermal agents, thus meeting the dual purpose of imaging and therapy. Here, we primarily discuss molecular imaging and therapeutic potentials of two such classes of materials, i.e., inorganic NIR dyes and metallic gold nanoparticle based materials.

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Section: Imaging and Photo-thermal Therapy Using Gold Nanoparticlesmentioning

confidence: 99%

Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation

Vats

Mishra

Baghini

et al. 2017

IJMS

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“…An updated overview on the development of new photosensitizers for anticancer photodynamic therapy was reported by Zhang et al, [30]. More clinical studies of the efficacy of PDT and PTT using various nanoparticles have been reported [31][32][33][34][35][36][37][38][39].…”

Section: Discussion Of Combined Ptt and Pdtmentioning

confidence: 99%

Progress of nanotechnology for phototherapy: Fundamentals and applications

Lin¹,

Chen²,

Liu³

2017

Med Devices Diagn Eng

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“…e) i) Preoperative PET-CT image, ii) intraoperative, and iii) postoperative images for LN mapping of a mouse with an orthotopic 4T1 breast tumor. [229] Tian's group successfully developed a CT/NIR imaging nanoplatform (Au@MSNs-ICG) by loading ICG-coated gold nanospheres into mesoporous silica NPs (MSNs), [231] on the basis of previous studies on ICG-loaded Au@SiO 2 . iv) SERRS imaging and v) the overlay of (ii) and (iv) of a tumor-bearing mouse with liver cancer.…”

Section: Pet/spect/ct-based Multimodal Imagingmentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle

Cited by 73 publications

References 56 publications

Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation

Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation

Progress of nanotechnology for phototherapy: Fundamentals and applications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

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