Cancer du sein avec atteinte ganglionnaire axillaire

Belaïd, Abdel; Kanoun, Samia; Kallel, A.; Ghorbel, Ismael; Azoury, F.; Heymann, S.; Pichenot, C.; Verstraet, R.; Marsiglia, H.; Bourgier, C.

doi:10.1016/s1278-3218(10)70017-2

Cited by 16 publications

(2 citation statements)

References 65 publications

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“…Breast cancer is one of the most common causes of cancer-associated mortality among the women worldwide [1,2]. It is estimated that over 1 million new breast cancer cases are diagnosed and roughly 370000 patients die of breast cancer around the world annually [3,4]. In the United States, 228000 new breast cancer cases and 40000 breast cancer-related deaths were estimated to occur every year [5,6].…”

Section: Introductionmentioning

confidence: 99%

LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer

2019

Bioscience Reports

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Numerous evidence has recently demonstrated that long non-coding RNAs (lncRNAs) play vital roles in the oncogenesis and development of a wide range of human neoplasms. Leukemia inhibitory factor receptor antisense RNA 1 (LIFR-AS1), a novel cancer-related lncRNA, has been reported to be under-expressed in breast cancer and associated with poor prognosis. However, the exact role of LIFR-AS1 in breast cancer remains largely unclear. The present study aimed to investigate the biological role of LIFR-AS1 in breast cancer and clarify the potential molecular mechanisms. In the present study, we found that LIFR-AS1 was significantly down-regulated in both tissues and cell lines. Furthermore, over-expression of LIFR-AS1 inhibited breast cancer cell proliferation, colony formation, migration and invasion, whereas knockdown of LIFR-AS1 promoted breast cancer cell proliferation, colony formation, migration and invasion. Moreover, LIFR-AS1 was observed to up-regulate suppressor of fused gene (Sufu) expression by competitively binding to miR-197-3p in breast cancer cells. Notably, miR-197-3p inhibitor reversed the promoting effects of LIFR-AS1 knockdown on breast cancer cell proliferation, colony formation, migration and invasion. Additionally, LIFR-AS1 knockdown promoted tumor growth in vivo. To sum up, our results imply the tumor-suppressing role of LIFR-AS1 in breast cancer.

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Section: Introductionmentioning

confidence: 99%

LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer

2019

Bioscience Reports

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“…Axillary LNs are the most common site of involvement in patients with BC that have spread beyond primary lesions (9). More than half of BC cases are associated with axillary LN involvement, which plays an important role in the prognosis of BC.…”

Section: Introductionmentioning

confidence: 99%

Lymph Node Involvement and Related Risk Factors in Patients With Breast Cancer Referred for Radiotherapy: A 20-Year Study on 15000 Women

Rousta

Dadashzadeh

Mahdavi

et al. 2021

International Journal of Women’s Health and Reproduction Scienc

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Objectives: Tumor size and axillary lymph node (LN) involvement are used as prognostic markers and a guide for choosing adjuvant therapy. This study aimed to evaluate LN involvement and related risk factors in patients with breast cancer (BC) referred for radiotherapy. Materials and Methods: Using the census sampling method, 15,000 women with BC referring for radiotherapy were enrolled in this retrospective descriptive study performed at Tabriz University of Medical Sciences during 2000-2020. LN involvement and related risk factors were recorded and analyzed using the t test and ANOVA test at a significance level of P<0.05. Results: The prevalence of LN involvement in this study was 25%. The estrogen receptor status and LN involvement were associated with metastasis. The odds ratio of metastasis in patients with a negative estrogen receptor was about twice that of women with estrogen receptor positivity. Finally, the risk of metastasis in patients presenting with LN involvement was eight times higher than that of patients without LN involvement. Conclusion: In general, estrogen receptor status and LN involvement were associated with metastasis in patients with BC. Thus, these factors can be regarded as a guide to start necessary interventions earlier in at-risk patients.

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Diagnostic Approach According to More Frequent Metastatic Sites: Liver, Lung, Bone, and Lymph Nodes

Aysal

Gündoğdu

Pehlivanoğlu

et al. 2022

Biomarkers in Carcinoma of Unknown Primary

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Cancer du sein avec atteinte ganglionnaire axillaire

Cited by 16 publications

References 65 publications

LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer

LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer

Lymph Node Involvement and Related Risk Factors in Patients With Breast Cancer Referred for Radiotherapy: A 20-Year Study on 15000 Women

Diagnostic Approach According to More Frequent Metastatic Sites: Liver, Lung, Bone, and Lymph Nodes

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