Cancer du sein chez la femme jeune de moins de 35 ans en Tunisie : étude rétrospective à propos de 124 cas

Bouzid, N.; Lahmar, Rihab; Tebra, Sameh; Bouaouina, N

doi:10.1016/j.gyobfe.2013.05.002

Cited by 11 publications

(26 citation statements)

References 24 publications

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“…Clinically, breast tumors in young women are characterized by delayed consultation and a frequency of high tumor sizes. This is confirmed in our study, where the tumors classified as T2 and T4 were predominant with respective rates of 45% and 29%, consistent with the results of other studies (1,6) . Immediate metastatic forms are seen in 2.4 to 30% of cases (8) .…”

Section: Discussionsupporting

confidence: 93%

“…In our series, this frequency was 24.42%, thus exceeding the frequency of the Occidental studies and concordant with the Maghreb studies. The average age of onset of breast cancer in the literature is often after 30 years (1,5,6) , which is consistent with our study with an average of 35.6 years. Several risk factors other than age are commonly associated with breast cancer in young women, including early menarche, nulliparity, first late pregnancy, and a family history of breast cancer.…”

Section: Discussionsupporting

confidence: 93%

“…In our study, we chose an age limit of 40 years. The incidence of breast cancer in young women varies between 1.3 and 25% (1,4,5,6) . In our series, this frequency was 24.42%, thus exceeding the frequency of the Occidental studies and concordant with the Maghreb studies.…”

Section: Discussionmentioning

confidence: 99%

“…In the pathological study, invasive breast carcinoma no special type is the most frequent histological type. It is all the more aggressive because it is associated with an SBR III grade, lymph node invasion, negative hormone receptors and overexpression of HER2 (1,4,5,6) . In our series, invasive breast carcinoma no special type was by far the most frequent (82.3%).…”

Section: Discussionmentioning

confidence: 99%

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Molecular Profile of Breast Cancer in Young Women in the Marrakech Region, Morocco: Experience of the Oncology Department CHU Mohamed VI Marrakech, Morocco

Bensallam¹,

Oumghar²,

Elomrani³

et al. 2017

IAM

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Breast cancer in young women is increasing. The objective of this work was to analyze the epidemiological, clinical, therapeutic and prognostic characteristics of breast cancer in young women under 40 years. Through a retrospective study spread over five years from 1 January 2008 to 31 December 2012 and held at the Radiation Oncology Service of the University Hospital Mohammed VI Marrakech, we identified 272 cases of breast cancer in patients aged 40 years and under. The frequency of breast cancer in young women under 40 years was 24.42%. The average age was 35.6 years. The pauciparity and nulliparity were predominant (60.6%). 8 % had a family history of breast cancer. The self-examination of a nodule was predominant (93%). Tumors classified T2 were the most frequent (45%), followed by T4 tumors (29%).17% were metastatic immediately with predominant hepatic localizations (37.6%). It was Invasive breast carcinoma no special type (NST) in 82.3% of cases, with a predominance of SBR grades II and III (96%). Hormone receptors were positive in 68% of cases and HER2 overexpressed in 29 % of cases. 218 patients underwent surgery, which was radical in 68% and conservative in 21%. 149 had a locoregional irradiation. 71% received adjuvant chemotherapy with a predominance of FAC60 protocol (35%). Hormonotherapy was prescribed in 78% of cases with positive hormone receptors and trastuzumab in 73.8 % of patients over expressing HER2. After a median follow-up of 8.1 months, 41.4 % had relapses. Overall survival at three years was 70%, and the relapse free survival was 62%. Our study joins the data in the literature advocating more advanced forms and worse prognosis of breast cancer in young patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Profile of Breast Cancer in Young Women in the Marrakech Region, Morocco: Experience of the Oncology Department CHU Mohamed VI Marrakech, Morocco

Bensallam¹,

Oumghar²,

Elomrani³

et al. 2017

IAM

View full text Add to dashboard Cite

show abstract

“…Although breast cancer occurs most often in women over age 50, reports have been published suggesting an increase in the incidence and mortality in young women in different populations worldwide (Wu et al, 2012;Bouzid et al, 2013;Johnson et al, 2013;Santos, 2013). In young women breast cancer is the leading cause of death in Western and in developing countries (American Cancer Society, 2012), constituting 5% to 7% of cases in some studies (Hayes, 2007).…”

Section: Discussionmentioning

confidence: 99%