Cancer Gene Therapy: The New Targeting Challenge

Touati, Walid; Beaune, Philippe; Waziers, Isabelle de

doi:10.5772/24788

Cited by 3 publications

(1 citation statement)

References 76 publications

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“…In the second step, an inactive prodrug is systemically administered, but is only activated into cytotoxic metabolites locally within the tumor cells expressing this enzyme. [390][391][392] To maximize the benefit of this approach, it is essential that the cytotoxic metabolites are able to diffuse through the cell membrane, since expression of the transgene does not occur in all tumor cells. This so-called "bystander" effect results in the death of not only the tumor cells in which the metabolites are formed but also the neighboring tumor cells that do not express the transgene.…”

Section: Mscs For Cancer Immunotherapymentioning

confidence: 99%

Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery

Almeida-Porada

Atala

Porada

2020

Molecular Therapy - Methods & Clinical Development

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Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when combined, make them ideally suited for cellular-based immunotherapy and as vehicles for gene and drug delivery for a wide range of diseases and disorders. Key among these are: (1) their relative ease of isolation from a variety of tissues; (2) the ability to be expanded in culture without a loss of functionality, a property that varies to some degree with tissue source; (3) they are relatively immune-inert, perhaps obviating the need for precise donor/recipient matching; (4) they possess potent immunomodulatory functions that can be tailored by so-called licensing in vitro and in vivo; (5) the efficiency with which they can be modified with viral-based vectors; and (6) their almost uncanny ability to selectively home to damaged tissues, tumors, and metastases following systemic administration. In this review, we summarize the latest research in the immunological properties of MSCs, their use as immunomodulatory/ anti-inflammatory agents, methods for licensing MSCs to customize their immunological profile, and their use as vehicles for transferring both therapeutic genes in genetic disease and drugs and genes designed to destroy tumor cells.Mesenchymal Stromal Cells (MSCs): Discovery, Origin, and Basic Biology Sources of MSCs and Tissue RepairAlthough much work to date has focused on MSCs isolated from adult murine and human BM, it is important to realize that tissuespecific MSCs, or pericytes, are now known to be widely distributed in perivascular regions of almost all tissues throughout the body, where they are thought to play an important role in tissue homeostasis, physiological remodeling, injury repair, and tissue regeneration

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Section: Mscs For Cancer Immunotherapymentioning

confidence: 99%