Cancer incidence among Finnish workers exposed to aromatic hydrocarbons

Anttila, Ahti; Pukkala, Eero; Riala, Riitta; Sallmén, Markku; Hemminki, Kari

doi:10.1007/s004200050269

Cited by 26 publications

(20 citation statements)

References 22 publications

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“…National Toxicology Program studies found no evidence of carcinogenic activity in mice and rats that were exposed to organic solvents at high doses [NTP, 1986[NTP, , 1990. Nevertheless, there have been a number of occupational exposure studies that have found excess cancer risk to solvent-exposed workers including cancers of the nervous system [Anttila et al, 1998], respiratory tract [Svensson et al, 1990], bone [Wiebelt and Becker, 1999], and liver and biliary tract [Lynge et al, 1997]. Our study found an elevated, though not statistically significant (SMR ¼ 1.05), risk of cancer death for this cohort.…”

Section: All Cancersupporting

confidence: 40%

“…Other studies of shoeworker cohorts [Enterline and McKiever, 1963;Decoufle and Walrath, 1983;Garabrant and Wegman, 1984;NIOSH, 1984;Pippard and Acheson, 1985;Schoenberg et al, 1987;Walrath et al, 1987;Brownson et al, 1993;Fu et al, 1996;Jöckel et al, 1998] and solvent-exposed worker populations [Svensson et al, 1990;Chen and Seaton, 1996;Anttila et al, 1998;Gerin et al, 1998;Wiebelt and Becker, 1999] have provided inconclusive results relating solvent exposure to lung cancer mortality and incidence.…”

Section: Lung Cancermentioning

confidence: 99%

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Mortality of workers employed in shoe manufacturing: An update

Lehman

Hein

2006

American J Industrial Med

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Section: All Cancersupporting

confidence: 40%

Section: Lung Cancermentioning

confidence: 99%

Mortality of workers employed in shoe manufacturing: An update

Lehman

Hein

2006

American J Industrial Med

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“…Conversely, other studies that examined toluene as a possible risk factor for cancer did not find any significant association between exposure to toluene and cancer. For example, Antilla et al [13] found no increase in overall cancer risk for cancers at specific tissues associated with exposure to toluene, except for a non-significant increase in the incidence of lung cancer in Finnish workers who were exposed to toluene for more than 10 years.…”

Section: Introductionmentioning

confidence: 99%

Assessing the distribution of volatile organic compounds using land use regression in Sarnia, "Chemical Valley", Ontario, Canada

Atari

Luginaah

2009

Environ Health

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BackgroundLand use regression (LUR) modelling is proposed as a promising approach to meet some of the challenges of assessing the intra-urban spatial variability of ambient air pollutants in urban and industrial settings. However, most of the LUR models to date have focused on nitrogen oxides and particulate matter. This study aimed at developing LUR models to predict BTEX (benzene, toluene, ethylbenzene, m/p-xylene and o-xylene) concentrations in Sarnia, 'Chemical Valley', Ontario, and model the intra-urban variability of BTEX compounds in the city for a community health study.MethodUsing Organic Vapour Monitors, pollutants were monitored at 39 locations across the city of Sarnia for 2 weeks in October 2005. LUR models were developed to generate predictor variables that best estimate BTEX concentrations.ResultsIndustrial area, dwelling counts, and highways adequately explained most of the variability of BTEX concentrations (R2: 0.78 – 0.81). Correlations between measured BTEX compounds were high (> 0.75). Although most of the predictor variables (e.g. land use) were similar in all the models, their individual contributions to the models were different.ConclusionYielding potentially different health effects than nitrogen oxides and particulate matter, modelling other air pollutants is essential for a better understanding of the link between air pollution and health. The LUR models developed in these analyses will be used for estimating outdoor exposure to BTEX for a larger community health study aimed at examining the determinants of health in Sarnia.

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“…1 The substantial worldwide variation in incidence rates for colorectal cancer may be explained by dietary and other environmental factors. 2 Colorectal cancer is not commonly considered to be occupational in etiology, but elevated risks have been reported among workers in the textile industry, 3,4 in the automobile industry, [5][6][7] in the beverage industry, 8 in subjects exposed to asbestos, 9-12 dioxin, 13 wood dust, 14 organic solvents [15][16][17] and metal-working fluids. 18 The risk of colorectal cancer is generally found to be lower in farmers, although the reason for these deficits are not entirely clear, lower smoking rates and higher levels of physical activity may be involved.…”

mentioning

confidence: 99%

Pesticide use and colorectal cancer risk in the agricultural health study

Lee

Sandler

Blair

et al. 2007

Intl Journal of Cancer

121

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We investigated the relationship between agricultural pesticides and colorectal cancer incidence in the Agricultural Health Study. A total of 56,813 pesticide applicators with no prior history of colorectal cancer were included in this analysis. Detailed pesticide exposure and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993)(1994)(1995)(1996)(1997). Cancer incidence was determined through populationbased cancer registries from enrollment through December 31, 2002. A total of 305 incident colorectal cancers (212 colon, 93 rectum) were diagnosed during the study period, 1993-2002. Although most of the 50 pesticides studied were not associated with colorectal cancer risk, chlorpyrifos use showed significant exposure response trend (p for trend 5 0.008) for rectal cancer, rising to a 2.7-fold (95% confidence interval: 1.2-6.4) increased risk in the highest exposure category. Aldicarb was associated with a significantly increased risk of colon cancer (p for trend 5 0.001), based on a small number of exposed cases, with the highest exposure category resulting in a 4.1-fold increased risk (95% confidence interval: 1.3-12.8). In contrast, dichlorophenoxyacetic acid showed a significant inverse association with colon cancer but the association was not monotonic. Our findings should be interpreted cautiously since the literature suggesting that pesticides are related to colorectal cancer is limited. Nonetheless the possibility of an association between exposure to certain pesticides and incidence of colorectal cancer among pesticide applicators deserves further evaluation. ' 2007 Wiley-Liss, Inc.

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Cancer incidence among Finnish workers exposed to aromatic hydrocarbons

Cited by 26 publications

References 22 publications

Mortality of workers employed in shoe manufacturing: An update

Mortality of workers employed in shoe manufacturing: An update

Assessing the distribution of volatile organic compounds using land use regression in Sarnia, "Chemical Valley", Ontario, Canada

Pesticide use and colorectal cancer risk in the agricultural health study

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