Cancer Incidence Among Pesticide Applicators Exposed to Chlorpyrifos in the Agricultural Health Study

Lee, Won Jin; Blair, Aaron; Hoppin, Jane A.; Lubin, Jay H.; Rusiecki, Jennifer; Sandler, Dale P.; Dosemeci, Mustafa; Alavanja, Michael C.R.

doi:10.1093/jnci/djh324

Cited by 164 publications

(139 citation statements)

References 35 publications

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“…In a previous analysis of cancer among chlorpyrifos users in the Agricultural Health Study cohort, we reported an increased risk of rectal cancer consistent with our current findings, as well as excesses for cancers of the lung and brain. 49,50 However, the biologic mechanisms for carcinogenicity of chlorpyrifos is not clear and should be further studied.…”

Section: Discussionmentioning

confidence: 99%

Pesticide use and colorectal cancer risk in the agricultural health study

Lee

Sandler

Blair

et al. 2007

Intl Journal of Cancer

121

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We investigated the relationship between agricultural pesticides and colorectal cancer incidence in the Agricultural Health Study. A total of 56,813 pesticide applicators with no prior history of colorectal cancer were included in this analysis. Detailed pesticide exposure and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993)(1994)(1995)(1996)(1997). Cancer incidence was determined through populationbased cancer registries from enrollment through December 31, 2002. A total of 305 incident colorectal cancers (212 colon, 93 rectum) were diagnosed during the study period, 1993-2002. Although most of the 50 pesticides studied were not associated with colorectal cancer risk, chlorpyrifos use showed significant exposure response trend (p for trend 5 0.008) for rectal cancer, rising to a 2.7-fold (95% confidence interval: 1.2-6.4) increased risk in the highest exposure category. Aldicarb was associated with a significantly increased risk of colon cancer (p for trend 5 0.001), based on a small number of exposed cases, with the highest exposure category resulting in a 4.1-fold increased risk (95% confidence interval: 1.3-12.8). In contrast, dichlorophenoxyacetic acid showed a significant inverse association with colon cancer but the association was not monotonic. Our findings should be interpreted cautiously since the literature suggesting that pesticides are related to colorectal cancer is limited. Nonetheless the possibility of an association between exposure to certain pesticides and incidence of colorectal cancer among pesticide applicators deserves further evaluation. ' 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Pesticide use and colorectal cancer risk in the agricultural health study

Lee

Sandler

Blair

et al. 2007

Intl Journal of Cancer

121

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“…43,71,79,84,89,97,111,120 Recent reports that evaluated atrazine (n 5 36,513 applicators), alachlor (n 5 26,510 applicators), chlorpyrifos (n 5 54,383 applicators) and glyphosate (n 5 57,311 applicators) exposure in the large US Agricultural Health Study cohort did not report significant overall associations with multiple myeloma, or significant exposure-response gradients based on lifetime or intensity-weighted days of exposure. 79,93,96,97 In a recent analysis of multiple myeloma mortality in the Agricultural Health Study cohort, Blair et al 92 reported nonsignificant inverse associations among licensed pesticide applicators (SMR 5 0.6, 95% CI: 0.3-1.2) and spouses of pesticide applicators (SMR 5 0.9, 95% CI: 0.3-2.1). Two other cohort studies that evaluated multiple myeloma incidence and mortality among licensed pesticide users reported no association (SIR 5 1.01, 95% CI: 0.49-1.87) among 20,245 Swedish applicators 114 and an inverse association (SMR 5 0.42, 95% CI: 0.14-0.99) among 23,401 licensed farmers in Italy.…”

Section: Pesticidesmentioning

confidence: 99%

Multiple myeloma: A review of the epidemiologic literature

et al. 2007

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Multiple myeloma, a neoplasm of plasma cells, accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no established lifestyle, occupational or environmental risk factors. Although several factors have been implicated as potentially etiologic, findings are inconsistent. We reviewed epidemiologic studies that evaluated lifestyle, dietary, occupational and environmental factors; immune function, family history and genetic factors; and the hypothesized precursor, monoclonal gammopathies of undetermined significance (MGUS). Because multiple myeloma is an uncommon disease, etiologic assessments can be difficult because of small numbers of cases in occupational cohort studies, and few subjects reporting exposure to specific agents in case-control studies. Elevated risks have been reported consistently among persons with a positive family history of LHC. A few studies have reported a relationship between obesity and multiple myeloma, and this may be a promising area of research. Factors underlying higher incidence rates of multiple myeloma in African Americans are not understood. The progression from MGUS to multiple myeloma has been reported in several studies; however, there are no established risk factors for MGUS. To improve our understanding of the causes of multiple myeloma, future research efforts should seek the causes of MGUS. More research is also needed on the genetic factors of multiple myeloma, given the strong familial clustering of the disease. ' 2007 Wiley-Liss, Inc.Key words: multiple myeloma; epidemiology Multiple myeloma is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. The specific immunoglobulin secreted by the malignant cell is the M-protein, named in reference to its monoclonal characteristics. It is found in the serum and/or urine of persons affected with multiple myeloma.

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“…Organophosphorous pesticides (OP) may affect sperm chromosome segregation and augment the risk for genetic syndromes (Recio et al 2001). Lee et al (2004) reported an association between chlorpyrifos use and incidence of lung cancer in Iowa and North Carolina. Pahwa et al (2011) observed the association of soft-tissue sarcoma with specific pesticides such as aldrin and diazinon in six regions of Canada.…”

Section: Introductionmentioning

confidence: 99%

Pesticide residues analysis in water samples of Nagarpur and Saturia Upazila, Bangladesh

et al. 2018

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Pesticides used to protect the crops from pest attack in the agricultural fields pose harmful effect to the non-target organisms such as human and many other aquatic and terrestrial organisms either directly or indirectly through food chain. The present study was conducted to monitor a total of seven pesticide residues under organochlorine, organophosphorus and carbamate pesticides in three different sources of pond water, paddy field water and tube-well water from Nagarpur Upazila and paddy field water in the company of Dhaleshwari and Gazikhali river water from Saturia Upazila, Bangladesh. A total of 40 water samples were analyzed using high-performance liquid chromatography equipped with ultraviolet detector. Among the organophosphorus pesticides, diazinon was detected in eight water samples at a concentration ranging from 4.11 to 257.91 μg/l whereas, malathion was detected only in one water sample at a concentration of 84.64 μg/l and chlorpyrifos pesticide was also detected only in one water sample and the concentration was 37.3 μg/l. Trace amount of carbaryl was identified but it was below the detection limit. None of the tested water samples was found to be contaminated with DDT or its metabolites (DDE and DDD). The water samples contaminated with the suspected pesticides were above the acceptable limit except for the fish pond samples of Sahabatpur and Dubaria union. To control the misuse of pesticides and to reduce the possible health risk, appropriate control systems of pests such as integrated pest management system should be implemented immediately by the authorities of the country.

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Cancer Incidence Among Pesticide Applicators Exposed to Chlorpyrifos in the Agricultural Health Study

Abstract: Our findings suggest an association between chlorpyrifos use and incidence of lung cancer that deserves further evaluation.

Cited by 164 publications

References 35 publications

Pesticide use and colorectal cancer risk in the agricultural health study

Pesticide use and colorectal cancer risk in the agricultural health study

Multiple myeloma: A review of the epidemiologic literature

Pesticide residues analysis in water samples of Nagarpur and Saturia Upazila, Bangladesh

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