Cancer Incidence Among Pesticide Applicators Exposed to Metolachlor in the Agricultural Health Study

Pesticides and prostate cancer: a review of epidemiologic studies with specific agricultural exposure information

“…The cohort studies reviewed included a cohort of Finnish men who sprayed brushwood vegetation with phenoxy herbicides (Asp et al, 1994), an Australian cohort of field staff employed by the Board of Tick Control in New South Wales who were involved in applying insecticides to cattle (Beard et al, 2003), reports of incidence and mortality endpoints in a cohort of pesticide applicators licensed in the state of Florida (Fleming et al, 1999a, b), and 10 published reports from the Agricultural Health Study cohort of pesticide applicators (Alavanja et al, 2003;Lee et al, 2004a, b;Rusiecki et al, 2004Rusiecki et al, , 2006Beane Freeman et al, 2005;Blair et al, 2005;Bonner et al, 2005;De Roos et al, 2005;Hou et al, 2006). Asp et al (1994) reported standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs) for total cancer and site-specific cancers, including prostate cancer, for the Finnish chlorophenoxy herbicide cohort after 18 years of follow-up.…”

Assessing environmental and occupational risk factors for lung cancer in Mexican–Americans

“…The most recent evidence of increased lung cancer risk comes from the Agricultural Health Study (AHS) that evaluated conventional pesticides to determine their possible role in lung cancer. Of the fifty conventional pesticides evaluated, only four (i.e., chlorpyifos, diazinon, metolachlor, and pendimethalin) showed an increased risk associated with pesticide use [22][23][24][25]. Although the AHS has produced the most recent evidence of an association between conventional pesticides and lung cancer, the cohort is mainly comprised of white males from Iowa or North Carolina.…”

Bladder cancer incidence and mortality rates compared to ecologic factors among states in America

“…Exposure to imazethapyr, a heterocyclic aromatic amine, was associated with significant increase in BCa among pesticide applicators in the Agricultural Health Study [14]. However, in another study of applicators in the Agricultural Health Study, no association between metolachlor use was found although there was also a nonsignificantly elevated risk for BCa in the highest exposure group [29].…”

“…Pesticide exposure has been linked to increased risks from BCa in some studies [10][11][12][13][14] but not all [29]. Pesticide exposures to French farmers in vineyards have been found to cause increased mortality from BCa [11].…”