Cancer incidence attributable to inadequate physical activity in Alberta in 2012

Brenner, Darren R.; Poirier, Abbey E.; Grundy, Anne; Khandwala, Farah; McFadden, Alison; Friedenreich, Christine M.

doi:10.9778/cmajo.20160044

Cited by 16 publications

(12 citation statements)

References 29 publications

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“…Previous studies suggested that, on average, 12% of breast cancers and 18% of colon cancers are attributable to lack physical activity (Friedenreich et al, 2010;Parkin et al, 2011;Wang et al, 2012;Hayes et al, 2013;Brenner, 2014;Park et al, 2014;Olsen et al, 2015;Van Gemert et al, 2015; Azevedo e Wilson, 2016;Brenner et al, 2017;Charafeddine et al, 2017;Naing et al, 2017). These results are similar to our PAF estimates, although comparing results is challenging due to methodological heterogeneity between studies (Table S4).…”

Section: Discussionsupporting

confidence: 88%

Atividade física e câncer: evidências epidemiológicas e perspectivas para prevenção do câncer no Brasil

Rezende¹

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LEANDRO FÓRNIAS MACHADO DE REZENDEAtividade física e câncer: evidências epidemiológicas e perspectivas para prevenção do câncer no Brasil DEDICATÓRIA À minha família AGRADECIMENTOS Ao meu orientador, José Eluf Neto, pela confiança, dedicação e incentivo.Aos meus queridos pais, pelo amor, pelos valores e ensinamentos preciosos e as oportunidades proporcionadas.Ao meu irmão, Guilherme, meu orgulho e admiração. À Ju, pelo amor, parceria e por estar sempre ao meu lado, mesmo quando a distância se fez presente.Ao Ringo, pelo amor incondicional e os lambeijos, todos os dias.Aos professores Alicia Matijasevich Manitto, Victor Wünsch Filho e Moyses Szklo, pelas preciosas contribuições no exame de qualificação de doutorado.Aos amigos/co-orientadores/conselheiros

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Section: Discussionsupporting

confidence: 88%

Atividade física e câncer: evidências epidemiológicas e perspectivas para prevenção do câncer no Brasil

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“…These risks are responsible for chronic diseases such as heart disease, diabetes and cancers (2009). According to the WHO report of 2009 (2009), physical activity (PA) is associated with a reduced risk of cardiovascular disease, some cancers (e.g., colorectal (Brenner et al, 2017;Eaglehouse et al, 2017), prostate, lung, breast, ovarian, endometrial (Brenner et al, 2017), oesophageal (Castro et al, 2017)), and type 2 diabetes (T2DM).…”

Section: Introduction -The Importance Of Physical Activity For Healthmentioning

confidence: 99%

Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer

Vitale

Lombardi

Weydahl

et al. 2018

Chronobiology International

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Rhythms can be observed at all levels of the biologic integration in humans. The observation that a biological or physiological variable shows a circadian rhythm can be explained by several multifactorial systems including external (exogenous), internal (endogenous) and psychobiological (lifestyle) mechanisms. Our body clock can be synchronized with the environment by external factors, called "synchronizers", i.e. the light-dark cycle, but it is also negatively influenced by some pathological conditions or factors, called "chronodisruptors," i.e. aging or low physical activity (PA). The desynchronization of a 24-h rhythm in a chronic manner has been recently defined "chronodisruption" or "circadian disruption." A very large number of hormonal variables, such as adrenal and gonadal stress steroids, are governed by circadian rhythmicity. Such hormones, in normal conditions, show a peak in the first part of the day, while their typical diurnal fluctuations are totally out of sync in subjects affected by cancer or metabolic diseases, such as obesity, diabetes and metabolic syndrome. In general, a flatter slope with altered peaks in cortisol and testosterone circadian rhythms has been observed in pathological individuals. PA, specifically chronic exercise, seems to play a key role as synchronizer for the whole circadian system in such pathologies even if specific data on steroids circadian pattern are still sparse and contradictory. Recently, it has been proposed that low-intensity chronic PA could be an effective intervention to decrease morning cortisol levels in pathological subjects. The standardization of all confounding factors is needed to reach more clear evidence-based results.

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“…We give comparisons between the UK and Alberta populations at the exposure-specific level in our previous articles. [2][3][4][5][6][7][8][9][10][11] In Australia, about 32% of cancers in 2010 were estimated to be attributable to 13 modifiable factors. 29 This estimate is lower than both our estimate for Alberta and the UK estimate.…”

Section: Discussionmentioning

confidence: 99%

“…1 As some factors were considered protective for cancer and others were cancer risk factors, Table 1 summarizes what we consider to be the theoretical minimum risk level of exposure for each lifestyle and environmental factor based on our research (unpublished data). [2][3][4][5][6][7][8][9][10][11] We estimated the total number of cancer cases attributable to the 24 risk factors by summing the number of cases of cancer at individual sites attributable to each individual exposure. Additional methods for the exposures included in this summary paper but not presented in separate exposure-specific papers are presented in Appendix 1, available at www.cmajopen.ca/ content/5/3/E540/suppl/DC1.…”

Section: Methodsmentioning

confidence: 99%

Cancer incidence attributable to lifestyle and environmental factors in Alberta in 2012: summary of results

et al. 2017

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T his paper is the last in a series of manuscripts estimating the proportion of cancer cases attributable to modifiable lifestyle and environmental risk factors in the general population of Alberta in 2012. The methodologic framework for this series has been previously described, 1 and detailed exposure-specific results are given in individual articles in this journal. 2-11A total of 16 330 new cancer cases were diagnosed and 5817 cancer deaths occurred in Alberta in 2012. Cancer was the second-leading cause of death in the province in 2012, accounting for 27% of all deaths. 12Population attributable risk is used to estimate the proportion of cases of a disease that can be attributed to an individual risk factor, and when multiple population attributable risk estimates are considered together, they can provide an estimate of the total disease burden attributable to a group of risk factors. In the cancer context, data on population attributable risk can inform cancer-prevention activities by identifying exposures that have the largest impact on disease incidence as well as estimating the proportion of cases that can be attributed to groups of known risk factors. Previously, Parkin and colleagues 13-27 estimated individual population attributable risks for several modifiable lifestyle and environmental cancer risk factors in the United Kingdom and estimated that, overall, 42.7% of cancer cases diagnosed in the UK in 2010 were Background: Estimates of the proportion of cancer cases that can be attributed to modifiable risk factors are not available for Canada and, more specifically, Alberta. The purpose of this study was to estimate the total proportion of cancer cases in Alberta in 2012 that could be attributed to a set of 24 modifiable lifestyle and environmental risk factors.

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Cancer incidence attributable to inadequate physical activity in Alberta in 2012

Cited by 16 publications

References 29 publications

Atividade física e câncer: evidências epidemiológicas e perspectivas para prevenção do câncer no Brasil

Atividade física e câncer: evidências epidemiológicas e perspectivas para prevenção do câncer no Brasil

Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer

Cancer incidence attributable to lifestyle and environmental factors in Alberta in 2012: summary of results

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