Cancer Incidence, Mortality, and Survival for Children, Adolescents, and Young Adults in Queensland Between 1987 and 2016

Holland, Lucy; Bradford, Natalie; Youl, Philippa; Cossio, Danica; Dunn, Nathan; Tran, Nancy; Walker, Rodney A.

doi:10.1089/jayao.2020.0151

Cited by 13 publications

(12 citation statements)

References 32 publications

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“…During the past two decades, significant improvements in the treatment of childhood cancer mean 80% of children in developed nations can expect to be long-term survivors. 1 This means, however, approxi-Abbreviations: CASP, Critical Appraisal Assessment Programme; PICU, pediatric intensive care unit; PROSPERO, Prospective Register for Systematic Reviews.…”

Section: Introductionmentioning

confidence: 99%

“…During the past two decades, significant improvements in the treatment of childhood cancer mean 80% of children in developed nations can expect to be long‐term survivors 1 . This means, however, approximately 20% of children will die from disease progression; indeed cancer remains the leading cause of non‐accidental death in children 2 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Location of end‐of‐life care of children with cancer: A systematic review of parent experiences

Noyes

Herbert

Moloney³

et al. 2022

Pediatric Blood & Cancer

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Objective To synthesize existing qualitative research exploring the experiences of parents caring for children with cancer during the end‐of‐life phase, and the factors that influence parental decision‐making when choosing the location of end‐of‐life care and death for their child. Results This review included 15 studies of 460 parents of 333 children and adolescents who died from progressive cancer. Where reported, the majority (58%) of children died at home or in a hospital (39%), with only a small fraction dying in a hospice. Factors impacting decision‐making for the location of care included the quality of communication and the quality of care available. Themes related to choosing home for end‐of‐life care and death included honoring the child's wishes, the familiarity of home, and parents’ desire to be their child's primary carer. Preference for the location of death in the hospital included trust in hospital staff, practical logistics, and the safety of the hospital environment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Location of end‐of‐life care of children with cancer: A systematic review of parent experiences

Noyes

Herbert

Moloney³

et al. 2022

Pediatric Blood & Cancer

View full text Add to dashboard Cite

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“…The fact that these futures may be prematurely cut short is unique to the context of AYAs, and thus highly distressing and developmentally challenging [9,10]. Further, AYA cancer mortality remains, on average, higher than pediatric cancer mortality [11][12][13]. Given these unique challenges, ensuring best-practice end-of-life care and communication for AYAs remains a clinical imperative in this era of novel therapies, precision medicines, and uncertain prognoses [14].…”

Section: Introductionmentioning

confidence: 99%

Thinking globally to improve care locally: A Delphi study protocol to achieve international clinical consensus on best-practice end-of-life communication with adolescents and young adults with cancer

et al. 2022

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For the sizeable subset of adolescents and young adults whose cancer is incurable, developmentally appropriate end-of-life discussions are critical. Standards of care for adolescent and young adult end-of-life communication have been established, however, many health-professionals do not feel confident leading these conversations, leaving gaps in the implementation of best-practice end-of-life communication. We present a protocol for a Delphi study informing the development and implementation of clinician training to strengthen health-professionals’ capacity in end-of-life conversations. Our approach will inform training to address barriers to end-of-life communication with adolescents and young adults across Westernized Adolescent and Young Adult Cancer Global Accord countries. The Adolescent and Young Adult Cancer Global Accord team involves 26 investigators from Australia, New Zealand, the United States, Canada and the United Kingdom. Twenty-four consumers, including adolescents and young adults with cancer history and carers, informed study design. We describe methodology for a modified Delphi questionnaire. The questionnaire aims to determine optimal timing for end-of-life communication with adolescents and young adults, practice-related content needed in clinician training for end-of-life communication with adolescents and young adults, and desireability of evidence-based training models. Round 1 involves an expert panel of investigators identifying appropriate questionnaire items. Rounds 2 and 3 involve questionnaires of international multidisciplinary health-professionals, followed by further input by adolescents and young adults. A second stage of research will design health-professional training to support best-practice end-of-life communication. The outcomes of this iterative and participatory research will directly inform the implementation of best-practice end-of-life communication across Adolescent and Young Adult Cancer Global Accord countries. Barriers and training preferences identified will directly contribute to developing clinician-training resources. Our results will provide a framework to support further investigating end-of-life communication with adolescents and young adults across diverse countries. Our experiences also highlight effective methodology in undertaking highly collaborative global research.

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“…With the increasing aging population, cancer has become one of the leading causes of death worldwide, and the number of cancer cases and deaths is only anticipated to grow further. Cancer is characterized by disturbed signals 1 and an unnatural disordered pattern formed by a large number of genetic and epigenetic changes that are related to the ultra-conservative, non-coding elements of the genome sequence. 2 Aging and a poor lifestyle increase the risk of cancer, 3 however, with the improvement of living standards, many lifestyle risk factors, such as smoking, lack of exercise, obesity, and reproductive patterns, have been widely reduced in high-income countries.…”

Section: Introductionmentioning

confidence: 99%

The Crosstalk Between Long Non-Coding RNAs and Various Types of Death in Cancer Cells

Tang

Zhu

Liang

et al. 2021

Technol Cancer Res Treat

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With the increasing aging population, cancer has become one of the leading causes of death worldwide, and the number of cancer cases and deaths is only anticipated to grow further. Long non-coding RNAs (lncRNAs), which are closely associated with the expression level of downstream genes and various types of bioactivity, are regarded as one of the key regulators of cancer cell proliferation and death. Cell death, including apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between lncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of tumors can be controlled by increasing or decreasing the expression of lncRNAs, a method which confers broad prospects for cancer treatment. Therefore, it is urgent for us to understand the influence of lncRNAs on the development of different modes of tumor death, and to evaluate whether lncRNAs have the potential to be used as biological targets for inducing cell death and predicting prognosis and recurrence of chemotherapy. The purpose of this review is to provide an overview of the various forms of cancer cell death, including apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis, and to describe the mechanisms of different types of cancer cell death that are regulated by lncRNAs in order to explore potential targets for cancer therapy.

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Cancer Incidence, Mortality, and Survival for Children, Adolescents, and Young Adults in Queensland Between 1987 and 2016

Cited by 13 publications

References 32 publications

Location of end‐of‐life care of children with cancer: A systematic review of parent experiences

Location of end‐of‐life care of children with cancer: A systematic review of parent experiences

Thinking globally to improve care locally: A Delphi study protocol to achieve international clinical consensus on best-practice end-of-life communication with adolescents and young adults with cancer

The Crosstalk Between Long Non-Coding RNAs and Various Types of Death in Cancer Cells

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