Cancer metastasis as a non-healing wound

Deyell, Matthew; Garris, Christopher; Laughney, Ashley M.

doi:10.1038/s41416-021-01309-w

Cited by 65 publications

(41 citation statements)

References 153 publications

(159 reference statements)

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“…Delayed and impaired healing is a multifactorial condition frequently associated with both abnormal body weight and stress overload [ 4 , 24 , 25 ]. In turn, impaired healing is indicative and predictive for a development and progression of many associated pathologies such as an aggressive metastatic disease, which is considered a “non-healing wound” [ 26 ]. Cellular responses to inflammation in both wound healing and metastasis are similar being tightly regulated by crosstalk with the surrounding microenvironment.…”

Section: Abnormal Stress Reactions As a General Risk Of Disease Development Manifestation And Progressionmentioning

confidence: 99%

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

et al. 2021

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An increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised “normal” body weight and individually optimal weight. To this end, the basic principle of personalised medicine “one size does not fit all” has to be applied. Contextually, “normal” but e.g. borderline body mass index might be optimal for one person but apparently suboptimal for another one strongly depending on the individual genetic predisposition, geographic origin, cultural and nutritional habits and relevant lifestyle parameters—all included into comprehensive individual patient profile. Even if only slightly deviant, both overweight and underweight are acknowledged risk factors for a shifted metabolism which, if being not optimised, may strongly contribute to the development and progression of severe pathologies. Development of innovative screening programmes is essential to promote population health by application of health risks assessment, individualised patient profiling and multi-parametric analysis, further used for cost-effective targeted prevention and treatments tailored to the person. The following healthcare areas are considered to be potentially strongly benefiting from the above proposed measures: suboptimal health conditions, sports medicine, stress overload and associated complications, planned pregnancies, periodontal health and dentistry, sleep medicine, eye health and disorders, inflammatory disorders, healing and pain management, metabolic disorders, cardiovascular disease, cancers, psychiatric and neurologic disorders, stroke of known and unknown aetiology, improved individual and population outcomes under pandemic conditions such as COVID-19. In a long-term way, a significantly improved healthcare economy is one of benefits of the proposed paradigm shift from reactive to Predictive, Preventive and Personalised Medicine (PPPM/3PM). A tight collaboration between all stakeholders including scientific community, healthcare givers, patient organisations, policy-makers and educators is essential for the smooth implementation of 3PM concepts in daily practice.

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Section: Abnormal Stress Reactions As a General Risk Of Disease Development Manifestation And Progressionmentioning

confidence: 99%

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

et al. 2021

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“…Solid tumors are complex structures of cancerous cells that are surrounded by a vascularized dynamic tumor stroma containing various non-malignant cells such as fibroblasts and myeloid cells. The prevailing conditions are similar to the inflammatory reaction during wound healing and favor angiogenesis, extracellular matrix (ECM) remodeling, and tumor cell motility [ 1 , 2 ]. Carcinogenesis and cancer progression depend on 10 classic hallmarks, plus four additional hallmarks for metastasis, i.e., invasive motility, modulation of the microenvironment, plasticity, and colonization [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression

Niland

Riscanevo

Eble

2021

IJMS

225

107

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Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which affect tissue integrity, immune cell recruitment, and tissue turnover by degrading extracellular matrix (ECM) components and by releasing matrikines, cell surface-bound cytokines, growth factors, or their receptors. Among the MMPs, MMP-14 is the driving force behind extracellular matrix and tissue destruction during cancer invasion and metastasis. MMP-14 also influences both intercellular as well as cell–matrix communication by regulating the activity of many plasma membrane-anchored and extracellular proteins. Cancer cells and other cells of the tumor stroma, embedded in a common extracellular matrix, interact with their matrix by means of various adhesive structures, of which particularly invadopodia are capable to remodel the matrix through spatially and temporally finely tuned proteolysis. As a deeper understanding of the underlying functional mechanisms is beneficial for the development of new prognostic and predictive markers and for targeted therapies, this review examined the current knowledge of the interplay of the various MMPs in the cancer context on the protein, subcellular, and cellular level with a focus on MMP14.

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“…The functional and structural abnormal vascular system that lacks a hierarchic architecture does not provide proper delivery of oxygen and nutrients and shows insufficient clearance of metabolic waste and carbonic dioxide which leads to a hostile environment where normoxic, hypoxic, and necrotic tissue is in the constant remodeling process. Dying cells secrete chemokines which lead together with that harsh environment to the recruitment of macrophages, that similar to the early phase of a wound start to (try to) repair ‘the wound that never heals’ [ 80 ].…”

Section: Tumor-associated Macrophagesmentioning

confidence: 99%

Tumor Microenvironment of Esophageal Cancer

Schiffmann

Plum

Fuchs

et al. 2021

Cancers

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Esophageal cancer is among the top ten most deadly cancers worldwide with adenocarcinomas of the esophagus showing increasing incidences over the last years. The prognosis is determined by tumor stage at diagnosis and in locally advanced stages by response to (radio-)chemotherapy followed by radical surgery. Less than a third of patients with esophageal adenocarcinomas completely respond to neoadjuvant therapies which urgently asks for further strategies to improve these rates. Aiming at the tumor microenvironment with novel targeted therapies can be one strategy to achieve this goal. This review connects experimental, translational, and clinical findings on each component of the esophageal cancer tumor microenvironment involving tumor angiogenesis, tumor-infiltrating immune cells, such as macrophages, T-cells, myeloid-derived suppressor cells, and cancer-associated fibroblasts. The review evaluates the current state of already approved concepts and depicts novel potentially targetable pathways related to esophageal cancer tumor microenvironment.

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Cancer metastasis as a non-healing wound

Cited by 65 publications

References 153 publications

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression

Tumor Microenvironment of Esophageal Cancer

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