Cancer, Mortality, and Acute Kidney Injury Among Hospitalized Patients with SARS-CoV-2 Infection

Khusid, Johnathan A.; Becerra, Adan Z.; Gallante, Blair; Sadiq, Areeba; Atallah, William; Badani, Ketan K.; Gupta, Mantu

doi:10.22541/au.160029800.02805523

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…(Figure 4) Figure 3. Drugs used in patients with COVID-19 10,14,15,17,24,25,29,31,32,[34][35][36][37][38]40,[42][43][44][45][46][47][48]50, . Based on the data, it also appeared that mechanical ventilation is an aggravating factor for AKI, which may be related to the worsening of the clinical conditions studied [OR 11.01, 95%CI: 10.29-11.77; p<0.01] (Figure 5).…”

Section: Resultsmentioning

confidence: 99%

“…Kidney involvement, including urinary abnormalities and changes in kidney function, is observed in approximately 75% of COVID-19 patients. AKI acts as a risk factor for hospital mortality in these patients 2,[28][29][30][31][32] . Therefore, this literature review examined the evolution of COVID-19 patients and the association between the disease and AKI.…”

Section: Introductionmentioning

confidence: 99%

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Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis

et al. 2022

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Background: Acute kidney injury (AKI) is a frequent complication of coronavirus-19 disease (COVID-19). Therefore, we decided to perform a systematic review and meta-analysis with data from the literature to relate the development of COVID-19 associated-AKI with comorbidities, medications, and the impact of mechanical ventilation. Methods: We performed a systematic review using the Newcastle-Ottawa scale and a meta-analysis using the R program. Relevant studies were searched in the PubMed, Medline, and SciELO electronic databases. Search filters were used to include reports after 2020 and cohort studies. Results: In total, 1166 articles were identified and 55 English-written articles were included based on the risk of bias. Of all COVID-19-hospitalized patients presenting with AKI (n = 18029) classified as Kidney Disease Improving Global Outcomes stage 1 to 3, approximately 18% required mechanical ventilation and 39.2 % died. Around 11.3% of the patients required kidney replacement therapy (KRT) and of these, 1093 died and 321 required continuous KRT. Death is more frequent in individuals with AKI [OR 6.03, 95%CI: 5.73-6.74; p<0.01]. Finally, mechanical ventilation is an aggravating factor in the clinical conditions studied [OR 11.01, 95%CI: 10.29-11.77; p<0.01]. Conclusion: Current literature indicates AKI as an important complication in COVID-19. In this context, we observed that comorbidities, such as chronic kidney disease and heart failure, were more related to the development of AKI. In addition, mechanical ventilation was seen as an aggravating factor in this scenario.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis

et al. 2022

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“…Figura 2. Comorbidades em pacientes com COVID-19 associada à lesão renal aguda 10,14,15,17,24,25,29,31,32,[34][35][36][37][38]40,[42][43][44][45][46][47][48] . Informações sobre a influência da LRA e o uso de ventilação mecânica em pacientes hospitalizados por COVID-19 apresentadas nos artigos foram extraídas e analisadas estatisticamente.…”

Section: Resultsunclassified

“…O envolvimento renal, incluindo anormalidades urinárias e alterações na função renal, é observado em aproximadamente 75% dos pacientes com COVID-19. A LRA atua como um fator de risco para a mortalidade hospitalar nestes pacientes 2,[28][29][30][31][32] . Portanto, esta revisão da literatura examinou a evolução de pacientes com COVID-19 e a associação entre a doença e a LRA.…”

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Desfechos de lesão renal aguda em pacientes com covid-19: revisão sistemática e metanálise

et al. 2022

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Resumo Antecedentes: Lesão renal aguda (LRA) é uma complicação frequente da doença do coronavírus-19 (COVID-19). Desta forma, decidimos realizar uma revisão sistemática e uma metanálise com dados da literatura para relacionar o desenvolvimento de LRA associada à COVID-19 com comorbidades, medicamentos e o impacto da ventilação mecânica. Métodos: Realizamos uma revisão sistemática usando a escala de Newcastle-Ottawa e uma metanálise utilizando o programa R. Estudos relevantes foram pesquisados nos bancos de dados eletrônicos PubMed, Medline e SciELO. Foram utilizados filtros de pesquisa para incluir relatos após 2020 e estudos de coorte. Resultados: No total, foram identificados 1166 artigos, e foram incluídos 55 artigos escritos em língua inglesa com base no risco de viés. De todos os pacientes hospitalizados por COVID-19 apresentando LRA (n = 18029) classificados como Kidney Disease Improving Global Outcomes estágios 1 a 3, aproximadamente 18% necessitaram de ventilação mecânica e 39,2% foram a óbito. Cerca de 11,3% dos pacientes necessitaram de terapia renal substitutiva (TRS) e destes, 1093 foram a óbito e 321 necessitaram de TRS contínua. O óbito é mais frequente em indivíduos com LRA [OR 6,03; IC95%: 5,73-6,74; p<0,01]. Por fim, a ventilação mecânica é um fator agravante nas condições clínicas estudadas [OR 11,01; IC95%: 10,29-11,77; p<0,01]. Conclusão: A literatura atual indica a LRA como uma complicação importante na COVID-19. Neste contexto, observamos que comorbidades, como doença renal crônica e insuficiência cardíaca, estiveram mais relacionadas ao desenvolvimento de LRA. Além disso, a ventilação mecânica foi vista como um fator agravante neste cenário.

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“…Several studies have found that hematological cancer and lung cancer were significantly associated with higher mortality (14)(15)(16). Infected patients with a history of genitourinary cancer did not have a higher risk of death compared to those without cancer (17). To date, few studies have investigated Omicron-variant infection in cancer patients, especially in tumors derived from the pancreatic and biliary systems, which is the leading cause of death worldwide.…”

Section: Discussionmentioning

confidence: 99%

Patients with advanced pancreatic and biliary cancer appear vulnerable to SARS-CoV-2 Omicron variant: An observational study during the COVID-19 outbreak in Shanghai

Han

Chen

et al. 2023

Front. Oncol.

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BackgroundThe COVID-19 pandemic has spread rapidly across the globe. Cancer patients have a higher risk of severe infections and associated mortality than the general population. However, the lethal effect of Omicron-variant affection on advanced pancreatic and biliary cancer patients is still not clear. Herein, we designed an observational study to shed light on the influence of the Omicron variant on this so-called “King of Cancer” and improve management of these patients with COVID-19 in the future.MethodsOmicron-infected patients with advanced pancreatic and biliary cancer were enrolled from 15 April to 31 May 2022. Four groups were set up in this study: Group 1, Omicron-infected cancer patients (N = 4); Group 2, non-infected cancer patients (N = 4); Group 3, infected non-cancer-afflicted subjects (N = 4); Group 4, non-infected non-cancer-afflicted subjects (N = 4). On Days 0, 7, and 14 after infection, the blood samples were collected dynamically from all subjects. The primary endpoints were disease severity and survival.ResultsAt the endpoint of this observational study, Patient Nos. 2, 3, and 4 died separately on Days 11, 25, and 13 after viral infection. All of them had advanced cancer, with a death rate of up to 75%. Group 1 presented an overall T-cell exhaustion status compared with other groups. Group 1 had obviously lower T-cell populations and higher B-cell percentages and CD4+T/CD8+T ratios (P <0.05). Time-course cytokine monitoring results showed that IL-1β was significantly decreased in Group 1 (P <0.05) and generally kept at a low level without obvious fluctuation. IL-6 was markedly increased in infected cancer patients (P <0.01) but remained at a low level and had no apparent change during the whole infection process in non-cancer-afflicted subjects. Furthermore, several inflammatory parameter indexes indicated a tight association of Omicron infection with the disease course and prognosis of Omicron-infected cancer patients.ConclusionsAdvanced pancreatic and biliary cancer patients with Omicron infection have severe symptoms and poor outcomes. More attention, protective measures, and routine healthcare services should be recommended to these vulnerable populations in clinical practice during the pandemic in the foreseeable future.

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Cancer, Mortality, and Acute Kidney Injury Among Hospitalized Patients with SARS-CoV-2 Infection

Cited by 3 publications

References 23 publications

Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis

Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis

Desfechos de lesão renal aguda em pacientes com covid-19: revisão sistemática e metanálise

Patients with advanced pancreatic and biliary cancer appear vulnerable to SARS-CoV-2 Omicron variant: An observational study during the COVID-19 outbreak in Shanghai

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