Cancer mortality in Down syndrome in California

Sasco, Annie J.; Day, Marc; Voirin, Nicolas; Strauss, David; Shavelle, Robert M.; Satgé, Daniel

doi:10.1515/ijdhd.2008.7.4.413

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…In contrast, three epidemiological studies on cancer incidence among individuals with Down syndrome identified only one lung cancer among 192 malignancies [ 29 – 31 ]. Further, two mortality studies reported an absence of lung cancer in this population, in which 17.68 and 4.39 cases would have been expected, thereby indicating that the condition may protect against lung cancer [ 32 , 33 ]. Because individuals with Down syndrome carry an extra copy of chromosome 21 (in part or whole), one or more of the 300 genes mapping to this chromosome could be responsible for the hypothesized protective effect [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Challenges in Diagnosis and Treatment of Lung Cancer in People with Intellectual Disabilities: Current State of Knowledge

Satgé¹,

Kempf

Dubois³

et al. 2016

Lung Cancer International

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As the life expectancy of people with intellectual disability (ID) has progressed, they have become similarly at risk of cancer as individuals of the general population. Epidemiological studies indicate a reduced incidence and mortality from lung cancer in the total population of persons with ID. However, the pattern is heterogeneous and the risk is strongly correlated with the impairment level; persons with mild intellectual impairment have higher cancer risk, and this subgroup also has the highest tobacco consumption (the major risk factor for lung cancer) compared to individuals with more severe impairment. Clinical presentation of lung cancer in persons with ID is often atypical, with symptoms frequently hidden by the mental state and communication impairments. Treatment can be impeded by incomplete understanding and lack of cooperation on the part of the patient; nevertheless, general principles for treating lung cancer must be applied to persons with ID. Early diagnosis and implementation of an adapted treatment plan may result in lung cancer outcomes similar to those of individuals in the general population. Physicians facing the difficult task of treating lung cancer in persons with ID are called to carry out their mission of care in a responsible, free, and creative way.

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Section: Resultsmentioning

confidence: 99%

Challenges in Diagnosis and Treatment of Lung Cancer in People with Intellectual Disabilities: Current State of Knowledge

Satgé¹,

Kempf

Dubois³

et al. 2016

Lung Cancer International

Self Cite

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show abstract

“…Three epidemiological studies on cancer incidence in people with DS conducted in Denmark, Finland, and Australia found just 1 case among 139 cancers, including 64 solid tumors in children and adults [5][6][7] . Additionally, 2 epidemiological studies on cancer mortality in DS found no lung tumors, despite expecting 17.68 and 4.39 cases, respectively 8,9 . The lower frequency of lung cancer in adults with DS has been attributed to a reduced exposure to tobacco smoke.…”

Section: Discussionmentioning

confidence: 98%

Adenocarcinoma of the Lung in down Syndrome: First Clinical Report

Satgé

Salmeron

Homsi

et al. 2013

Tumori

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Lung cancer is rare in persons with Down syndrome, and the clinical presentation of the disease has not been described in adults with intellectual disability. We report the first detailed clinical observation of a 33-year-old man with Down syndrome who developed an adenocarcinoma of the lung 30 years after an acute lymphoblastic leukemia in infancy. Despite advanced disease at initial presentation and extensive tumor spreading during the course of the disease, he presented with unusually mild symptoms. The scarcity of lung cancer in people with intellectual disability, and particularly those with Down syndrome, is due, in part, to reduced tobacco use. However, cytogenetic and molecular studies suggest that genes mapping to chromosome 21 may protect against lung cancer. Numerous reports also suggest that, in persons with Down syndrome and other intellectual disability, cancers are often discovered late, leading to loss of the chance of cure and recovery.

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Cancer mortality in Down syndrome in California

Cited by 2 publications

References 27 publications

Challenges in Diagnosis and Treatment of Lung Cancer in People with Intellectual Disabilities: Current State of Knowledge

Challenges in Diagnosis and Treatment of Lung Cancer in People with Intellectual Disabilities: Current State of Knowledge

Adenocarcinoma of the Lung in down Syndrome: First Clinical Report

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