Cancer of the vulva

Hacker, Neville F.; Eifel, Patricia J.; Velden, J. van der

doi:10.1016/j.ijgo.2015.06.002

Cited by 47 publications

(123 citation statements)

References 59 publications

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“…Although this treatment regimen proved to be successful in several studies, treatment-related morbidity was high causing significant postoperative complications, including wound breakdowns and treatment-related death [6]. Another disadvantage of preoperative chemoradiation is that salvage radiotherapy is no longer a treatment option [2].…”

Section: Discussionmentioning

confidence: 99%

“…Vulvar cancer is a rare gynecological malignancy that constitutes about 3% of all gynecological cancers with an incidence of 2-3 per 100,000 women per year [1,2]. During the last decades, treatment of vulvar cancer has evolved from a radical procedure into a more conservative and individualized multidisciplinary approach.…”

Section: Introductionmentioning

confidence: 99%

“…During the last decades, treatment of vulvar cancer has evolved from a radical procedure into a more conservative and individualized multidisciplinary approach. Current standard care of treatment is surgical and consists of radical local excision and sentinel node procedure of the groins or bilateral inguinal lymph node dissection depending on tumor characteristics [1,2]. This less radical approach has led to a major decrease in treatment-associated morbidity without compromising prognosis [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Current standard care of treatment is surgical and consists of radical local excision and sentinel node procedure of the groins or bilateral inguinal lymph node dissection depending on tumor characteristics [1,2]. This less radical approach has led to a major decrease in treatment-associated morbidity without compromising prognosis [2,3]. Despite the high need, little progress has been made in the development of new treatment modalities for advanced stage or recurrent vulvar cancer.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, musculo-cutaneous transposition flaps may be necessary to close large defects on the vulva and perineum. Furthermore, surgery is not always possible for patients with large primary tumors [2].…”

Section: Introductionmentioning

confidence: 99%

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Brief Report on 3-Weekly Paclitaxel Carboplatin Efficacy in Locally Advanced or Metastatic Squamous Vulvar Cancer

Amant

Nooij

Annibali

et al. 2018

Gynecol Obstet Invest

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In this brief report, we present our experience with 3-weekly paclitaxel-carboplatin chemotherapy for patients with vulvar cancer. Two patients with locally advanced disease had an impressive response allowing standard vulvar cancer surgery. One patient with metastatic disease had local stable disease though it was progressive in the lymph nodes. The available literature is sparse and retrospective. Based on promising results, however, a prospective multicenter study is mandatory in order to obtain full data in a larger series of patients in order to learn the benefits of neoadjuvant paclitaxel-carboplatin and compare the results with chemoradiation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Brief Report on 3-Weekly Paclitaxel Carboplatin Efficacy in Locally Advanced or Metastatic Squamous Vulvar Cancer

Amant

Nooij

Annibali

et al. 2018

Gynecol Obstet Invest

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Abdominopelvic washings in gynecologic pathology: A comprehensive review

Schulte

Lastra

2016

Diagnostic Cytopathology

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Abdominopelvic washings (APW) performed during gynecologic surgeries have become a common specimen evaluated by cytopathologists. Their role in staging of female genital tract tumors has changed significantly since they were first described, and continue to evolve. The ability of these washings to detect microscopic disease, even in the absence of gross disease, warrants the critical role that these washings play in the staging of certain female gynecologic tract tumors, allowing for optimal staging and subsequent treatment of the patient. Irrespective of the underlying pathology, the gamut of cytomorphologic findings that may be observed in APW is extensive, and ranges from benign lesions that may act as mimickers of malignancy, to both common and rare malignancies. This review discusses the changing role of APW in the staging of gynecologic tumors, and highlights the salient cytomorphologic features of these lesions, with emphasis in their correct identification, including cautionary notes to avoid over or misinterpretation. Diagn. Cytopathol. 2016;44:1039-1057. © 2016 Wiley Periodicals, Inc.

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Cancer of the vulva

Rogers

Cuello

2018

Intl J Gynecology & Obste

131

125

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Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. There is no specific screening and the most effective strategy to reduce vulvar cancer incidence is the opportune treatment of predisposing and preneoplastic lesions associated with its development. While vulvar cancer may be asymptomatic, most women present with vulvar pruritus or pain, or have noticed a lump or ulcer. Therefore, any suspicious vulvar lesion should be biopsied to exclude invasion. Once established, the most common subtype is squamous cell carcinoma. Treatment of vulvar cancer depends primarily on histology and surgical staging. Treatment is predominantly surgical, particularly for squamous cell carcinoma, although concurrent chemoradiation is an effective alternative, particularly for advanced tumors. Management should be individualized, and carried out by a multidisciplinary team in a cancer center experienced in the treatment of these tumors.

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Cancer of the vulva

Cited by 47 publications

References 59 publications

Brief Report on 3-Weekly Paclitaxel Carboplatin Efficacy in Locally Advanced or Metastatic Squamous Vulvar Cancer

Brief Report on 3-Weekly Paclitaxel Carboplatin Efficacy in Locally Advanced or Metastatic Squamous Vulvar Cancer

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Cancer of the vulva

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